A5008003734- Radiopharmaceutical Chemistry and Applications
- Orthopedic Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Medical Imaging Techniques and Applications
- Pacific and Southeast Asian Studies
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Cassava research and cyanide
- Agronomic Practices and Intercropping Systems
- Agricultural Economics and Practices
- Antimicrobial Peptides and Activities
- Plant tissue culture and regeneration
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Agricultural Science and Fertilization
- Prostate Cancer Treatment and Research
- Seed and Plant Biochemistry
- Nanoplatforms for cancer theranostics
- Prostate Cancer Diagnosis and Treatment
- Plant Genetic and Mutation Studies
- Seed Germination and Physiology
- Plant Pathogens and Fungal Diseases
- Medical Imaging and Pathology Studies
- Isotope Analysis in Ecology
Bhabha Atomic Research Centre
2016-2025
Homi Bhabha National Institute
2018-2025
Central Tuber Crops Research Institute
2008-2022
Indian Council of Agricultural Research
2019
University of Tennessee at Knoxville
2018
ICAR Research Complex for NEH Region
2018
Kovai Medical Center and Hospital
2017
Czech Agrifood Research Center
2015
Khulna University
2012
Thomas Jefferson University
2009
Taro (Colocasia esculenta (L.) Schott) is widely distributed in tropical and sub-tropical areas. However, its origin, diversification dispersal remain unclear. While taro genetic diversity has been documented at the country regional levels Asia Pacific, few reports are available from Americas Africa where it introduced through human migrations. We used eleven microsatellite markers to investigate of accessions nineteen countries Asia, America. The highest number private alleles were observed...
The structure and in vitro antiproliferative activity of anthocyanins the root tubers a sweet potato variety cv. Bhu Krishna purple leaves promising accession S-1467 were studied with objectives understanding structure-activity relationship comparing leaf tuber anthocyanins. chemical was determined by high-resolution electrospray ionization mass spectrometry analysis. A fluorescence-resonance-energy-transfer-based caspase sensor probe had been used to study property, analysis cell cycle...
In this study, a novel antibody-drug conjugate (ADC) consisting of Rituximab and Chlorambucil (Rituximab-CMB) was synthesized. The average number drug molecules attached per molecule determined using MALDI-TOF mass spectrometry, revealing range 4-6 antibody. To further improve the therapeutic potential ADC, it radiolabeled with radionuclide 177Lu via DOTA chelator, achieving final radiochemical purity over 95%. vitro assays demonstrated that Rituximab-CMB had greater cytotoxicity compared to...
The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents for imaging infection. focused largely on bacterial pathogens. group discussed evaluated advantages disadvantages several radiopharmaceuticals, as well science driving various approaches. main objective was to understand why few infection-targeted radiotracers...
Ubiquicidin (UBI)/ribosomal protein S30 (RS30) is an intracellular with antimicrobial activities against various pathogens. UBI (29–41) and (31–38) are two crucial peptides derived from Ubiquicidin, which have shown potential as infection imaging probes. Here, we report the interactions of UBI-derived anionic zwitterionic phospholipid membranes. Our isothermal titration calorimetry results show that both selectively interact membrane (a model bacterial membrane) reside mainly on surface. The...
Abstract Background The urgent demand for innovative theranostic strategies to combat bacterial resistance antibiotics is evident, with substantial implications global health. Rapid diagnosis of life-threatening infections can expedite treatment, improving patient outcomes. Leveraging diagnostic modalities i.e., positron emission tomography (PET) and single photon computed (SPECT) detecting focal has yielded promising results. Augmenting the sensitivity current PET SPECT tracers could enable...
The experiment was conducted in the Agronomy Laboratory of Agrotechnology Discipline, Khulna University, from 29th August to 17th September, 2009. laid out a Completely Randomized Design (CRD) with two factors and three replications. aim study efficacy osmopriming agents viz ., NaCl, KC1 CaCb control on seed germination seedling growth T. aman rice varities viz., BRRI dhan40, dhan41 BINA dhan7. Among chemicals showed best as it enhanced all parameters. performance. Better root length shoot...
Developing potent and novel bacterial imaging agents remains formidable due to the rapid development of resistance. Ubiquicidin its derivatives are most studied antimicrobial peptides that bind anionic membranes a broad range pathogens. Studies reveal UBI (29-41) labeled with 99mTc 68Ga could distinguish sterile inflammation from infection. A significant challenge for cationic is their poor salt tolerance. The present study deliberates increment peptide interaction membrane by incorporating...
Abstract Highest global cancer incidence of female breast is a matter great concern. HER2-positive cancers have high mortality rate hence detection at an early stage vital for successful treatment, improved care and survival rate. Radiolabeled peptides emerged as new alternatives to radiolabeled antibodies overcome the limitations slow clearance uptake in non-target tissues. Herein, DOTA-A9 peptide its pegylated variant were constructed on solid phase with [ 177 Lu]LuCl 3 . Lu]DOTA-A9...
The retro analog of the HER2-targeting A9 peptide was synthesized by coupling amino acids in a reverse fashion and switching N-terminal original sequence L-A9 (QDVNTAVAW) to C-terminal rL-A9 (WAVATNVDQ). Modification backbone resulted higher conformational stability as evident from CD spectra. Molecular docking analysis revealed HER2 binding affinity [177Lu]Lu-DOTA-rL-A9 than radiopeptide [177Lu]Lu-DOTA-L-A9. Enormously enhanced metabolic led significant elevation tumor uptake retention....
Objective The aim was to evaluate the diagnostic potential of 68Ga-ubiquicidin positron-emission tomography/computed tomography (PET/CT) in imaging patients with infection. Materials and methods 68Ga-NOTA-ubiquicidin (68Ga-UBI) prepared by addition freshly eluted 68Ga-chloride from 68Ge/68Ga generator into NOTA-ubiquicidin vial incubated at room for 15 min 90°C. After compounding radiopharmaceutical, quality control using instant thin-layer chromatography, culture endotoxin estimation...
Abstract Cellular temperature and pH govern many cellular physiologies, especially of cancer cells. Besides, attaining higher plays key role in therapeutic efficacy hyperthermia treatment cancer. This requires bio-compatible, non-toxic sensitive probe with dual sensing ability to detect variations. In this regard, fluorescence based nano-sensors for studies play an important role. Therefore, a facile green synthesis orange carbon nano-dots (CND) high quantum yield 90% was achieved its...