A5101492922- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Heart Rate Variability and Autonomic Control
- Retinal Development and Disorders
- EEG and Brain-Computer Interfaces
- Protein purification and stability
- Advanced Biosensing Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cognitive Abilities and Testing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Retinal Imaging and Analysis
- Genetics and Neurodevelopmental Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Advanced MRI Techniques and Applications
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Fractal and DNA sequence analysis
- Biochemical Analysis and Sensing Techniques
- vaccines and immunoinformatics approaches
- Biomedical Text Mining and Ontologies
University of North Carolina at Chapel Hill
2019-2025
University of Electronic Science and Technology of China
2022-2025
University of North Carolina Health Care
2024
Imaging Center
2021-2022
Capital Normal University
2016-2021
Wenzhou Medical University
2021
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2019
Yixing People's Hospital
2016
Jiangsu University
2016
Southeast University
2013-2015
Connecting the dots on white matter The of brain, which is composed axonal tracts connecting different brain regions, plays key roles in both normal function and a variety neurological disorders. Zhao et al. combined detailed magnetic resonance imaging–based assessment structures with genetic data nearly 44,000 individuals (see Perspective by Filley). On basis this comprehensive analysis, authors identified structural abnormalities associated psychiatric disorders, as well some nondisease...
Cardiovascular health interacts with cognitive and mental in complex ways, yet little is known about the phenotypic genetic links of heart-brain systems. We quantified connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns brain gray matter morphometry, white microstructure, functional networks. identified 80 associated genomic loci (
Abstract The retina, an anatomical extension of the brain, forms physiological connections with visual cortex brain. Although retinal structures offer a unique opportunity to assess brain disorders, their relationship structure and function is not well understood. In this study, we conducted systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. We identified novel phenotypic links between biomarkers measures from multimodal magnetic resonance (MRI),...
Fiber photometry is an emerging technique for recording fluorescent sensor activity in the brain. However, significant hemoglobin absorption artifacts fiber data may be misinterpreted as changes. Because exists widely brain, and its concentration varies temporally, such could impede accuracy of recordings. Here we present use spectral computational methods to quantify photon effects by using activity-independent fluorescence signals, which can used derive oxy- deoxy-hemoglobin Although these...
Objectives The thalamus and cerebral cortex are connected via topographically organized, reciprocal connections, which hold a key function in segregating internally externally directed awareness information. Previous task-related studies have revealed altered activities of the after total sleep deprivation (TSD). However, it is still unclear how TSD impacts on communication between cortex. In this study, we examined changes thalamocortical functional connectivity 36 hours by using resting...
Objectives Recent neuroimaging studies have identified a potentially critical role of the amygdala in disrupted emotion neurocircuitry individuals after total sleep deprivation (TSD). However, connectivity between and cerebral cortex due to TSD remains be elucidated. In this study, we used resting-state functional MRI (fMRI) investigate changes basolateral (BLA) centromedial (CMA) brain 36 h TSD. Materials Methods Fourteen healthy adult men aged 25.9±2.3 years (range, 18–28 years) were...
Abstract Structural variations of the human brain are heritable and highly polygenic traits, with hundreds associated genes identified in recent genome-wide association studies (GWAS). Transcriptome-wide (TWAS) can both prioritize these GWAS findings also identify additional gene-trait associations. Here we perform cross-tissue TWAS analysis 211 structural neuroimaging discover 278 exceeding Bonferroni significance threshold 1.04 × 10 −8 . The TWAS-significant for structures have been linked...
Abstract Although Type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for dementia, the neural mechanisms that underlie cognitive impairment in T2DM remain unclear. This study uses resting-state functional magnetic resonance imaging (fMRI) to examine attention network alterations and their relationships impaired performance. Data-driven independent component analysis was applied fMRI data from 38 patients 32 healthy controls identify dorsal (DAN) ventral (VAN). Correlations were...
Abstract As an anatomical extension of the brain, retina eye is synaptically connected to visual cortex, establishing physiological connections between and brain. Despite unique opportunity retinal structures offer for assessing brain disorders, less known about their relationship structure function. Here we present a systematic cross-organ genetic architecture analysis eye-brain using imaging endophenotypes. Novel phenotypic links were identified biomarkers function measures derived from...
Antibodies play a crucial role in the vertebrate immune system and have diverse biomedical applications. Understanding intricate interactions between antibodies antigens is an important step drug development. However, complex vast nature of data presents significant challenges accurately identifying comprehending these interactions. To address enhance our understanding antibody-antigen interface, Antigen-Antibody Complex Database (AACDB) has been established. The current version provides...
Antibodies play a crucial role in the vertebrate immune system and have diverse biomedical applications. Understanding intricate interactions between antibodies antigens is an important step drug development. However, complex vast nature of data presents significant challenges accurately identifying comprehending these interactions. To address enhance our understanding antibody-antigen interface, Antigen-Antibody Complex Database (AACDB) has been established. The current version provides...
Genes on the X chromosome are extensively expressed in human brain. However, little is known for chromosome’s impact brain anatomy, microstructure, and functional networks. We examined 1045 complex imaging traits from 38,529 participants UK Biobank. unveiled potential autosome–X interactions while proposing an atlas outlining dosage compensation traits. Through extensive association studies, we identified 72 genome-wide significant trait-locus pairs (including 29 new associations) that share...
Debate remains on whether hypercholesterolemia is associated with cognitive impairment. Hence, we investigated poorly controlled cholesterol impairs functional connectivity among patients type 2 diabetes mellitus (T2DM).
We aim to investigate whether decreased interhemispheric functional connectivity exists in patients with type 2 diabetes mellitus (T2DM) by using resting-state magnetic resonance imaging (rs-fMRI). In addition, we sought determine deficits associated cognition and insulin resistance (IR) among T2DM patients. compared the resting state of 32 30 healthy controls rs-fMRI. Partial correlation coefficients were used detect relationship between rs-fMRI information cognitive or clinical data....
INTRODUCTION: The influence of sex on the prevalence and clinical manifestations functional dyspepsia (FD) has recently been a topic increasing interest. However, brain MRI pathology based sexual dimorphism in FD not yet investigated. amygdala, which plays vital role processing gastrointestinal signals, may be associated with sex-related pathophysiology FD. METHODS: We investigated resting-state connectivity (rsFC) amygdala subregions patients healthy subjects as well differences between...
Therapeutic antibodies play a crucial role in the treatment of various diseases. However, success rate antibody drug development is low partially because unfavourable biophysical properties candidates such as high aggregation tendency, which mainly driven by hydrophobic interactions molecules. Therefore, early screening risk interaction crucial. Experimental laborious, time-consuming, and costly, warranting efficient high-throughput computational tools for prediction therapeutic antibodies....
Abstract The human cerebral cortex is a vital component of brain function, but the genetic influences on cortical functional organization remain poorly understood. In this study, we used parcellation-based approach to process resting-state and task-evoked magnetic resonance imaging (fMRI) from over 48,000 individuals in UK Biobank ABCD studies. We identified 47 loci associated with areas networks at rest, 15 which also affected connectivity during task performance. observed patterns...
Abstract Brain regions communicate with each other via tracts of myelinated axons, commonly referred to as white matter. White matter microstructure can be measured in the living human brain using diffusion based magnetic resonance imaging (dMRI), and has been found altered patients neuropsychiatric disorders. Although under strong genetic control, few variants influencing have ever identified. Here we identified common dMRI 42,919 individuals (35,741 UK Biobank). The dMRIs were summarized...
Abstract Genes on the X-chromosome are extensively expressed in human brain. However, little is known for X-chromosome’s impact brain anatomy, microstructure, and functional network. We examined 1,045 complex imaging traits from 38,529 participants UK Biobank. unveiled potential autosome-X-chromosome interactions, while proposing an atlas outlining dosage compensation (DC) traits. Through extensive association studies, we identified 72 genome-wide significant trait-locus pairs (including 29...
Abstract Antibodies play a crucial role in the vertebrate immune system and have diverse biomedical applications. Understanding intricate interactions between antibodies antigens is an important step drug development. However, complex vast nature of data presents significant challenges accurately identifying comprehending these interactions. To address enhance our understanding antibody-antigen interface, Antigen-Antibody Complex Database (AACDB) has been established. The current version...