A5101710806- Adipose Tissue and Metabolism
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- FOXO transcription factor regulation
- Liver physiology and pathology
- Macrophage Migration Inhibitory Factor
- Immune cells in cancer
- Tuberculosis Research and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Nuclear Structure and Function
Chongqing Medical University
2024
Sun Yat-sen University
2023-2024
Third Affiliated Hospital of Sun Yat-sen University
2023
Key Laboratory of Guangdong Province
2023
Qilu Hospital of Shandong University
2009
Ministry of Education of the People's Republic of China
2007
Abstract Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies organ preservation, calling for better understanding cold adaptation. Here, by surveying cold-altered chromatin accessibility integrated CUT&Tag/RNA-seq analyses in human stem cells, we reveal forkhead box O1 (FOXO1) as a key transcription factor autonomous Accordingly, find nonconventional, temperature-sensitive FOXO1 transport mechanism involving the nuclear pore complex protein RANBP2,...
In this study, we investigated the in vivo role of adiponectin, an adipocytokine, on development atherosclerosis rabbits mainly using adenovirus expressing adiponectin gene (Ad-APN) and intravascular ultrasonography. Serum concentrations after Ad-APN local transfer to abdominal aortas increased about nine times as much those before ( P < 0.01), ten levels endogenous β-galactosidase (Ad-β gal) treated four aorta non-injured a normal cholesterol diet 0.01). Ultrasonography revealed...
BackgroundAntibody-mediated rejection (ABMR) significantly affects transplanted kidney survival, yet the macrophage phenotype, ontogeny, and mechanisms in ABMR remain unclear.MethodMethod: We analyzed post-transplant sequencing clinical data from GEO ArrayExpress. Using dimensionality reduction clustering on scRNA-seq data, we identified subpopulations compared their infiltration non-rejection cases. Cibersort quantified these bulk samples. Cellchat, SCENIC, monocle2, monocle3 helped explore...
Inadequate remnant volume and regenerative ability of the liver pose life-threatening risks to patients after partial transplantation (PLT) or hepatectomy (PHx), while few clinical treatments focus on safely accelerating regeneration. Recently, we discovered that supplementing 5-aminolevulinate (5-ALA) improves cold adaptation functional recovery, leading us uncover a correlation between 5-ALA metabolic activities post-PLT recovery. In mouse 2/3 PHx model, supplements enhanced regeneration,...
Adiponectin is an adipose‐derived hormone that has anti‐diabetic and anti‐atherogenic effects through interaction with AdipoR1 AdipoR2 (adiponectin receptors 1 2), but little known about the expression function of adiponectin its in adventitia adventitial fibroblasts. In present study, we have demonstrated highly expressed rat cultured fibroblasts by quantitative real‐time PCR, Western blotting immunofluorescent staining, whereas Adipo2 low‐expressed. The been observed to decrease gradually...
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