A5066743744- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Bacillus and Francisella bacterial research
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Plant Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Microbial infections and disease research
- vaccines and immunoinformatics approaches
- Rabies epidemiology and control
- Monoclonal and Polyclonal Antibodies Research
- Molecular Biology Techniques and Applications
- Migration, Ethnicity, and Economy
- Transgenic Plants and Applications
Commonwealth Scientific and Industrial Research Organisation
2012-2025
Australian Centre for Disease Preparedness
2009-2025
CSIRO Health and Biosecurity
2015-2019
Animal, Food and Health Sciences
2013
University of Manitoba
2007
The University of Melbourne
1994
Lumpy skin disease along with sheep pox and goatpox are the most serious poxvirus diseases of livestock, caused by viruses that belong to genus Capripoxvirus within subfamily Chordopoxvirinae, family Poxviridae. To facilitate study lumpy pathogenesis, we inoculated eight 4- 6-month-old Holstein calves intravenously virus (LSDV) collected samples over a period 42 days for analysis isolation, real-time PCR light microscopy. Following inoculation, cattle developed fever nodules, extent...
The genus Capripoxvirus in the subfamily Chordopoxvirinae, family Poxviridae, comprises sheeppox virus (SPPV), goatpox (GTPV) and lumpy skin disease (LSDV), which cause eponymous diseases across parts of Africa, Middle East Asia. These significant economic losses can have a devastating impact on livelihoods food security small farm holders. So far, only live classically attenuated SPPV, GTPV LSDV vaccines are commercially available history, safety efficacy many not been well established....
An indirect ELISA was developed to detect antibodies specific for capripoxviruses in goat, sheep and cattle sera. Heat-inactivated Nigerian sheeppox virus used as the antigen. Sera obtained from goats that were experimentally infected with different capripoxvirus isolates develop evaluate sensitivity of ELISA. Virus neutralization indexes determined experimental sera OA3.Ts cells. The specificity using 231 naïve Canada. In addition, tested cross-reactivity anti-orf orf-reactive no observed....
Sheeppox and goatpox are caused by viruses that members of the genus Capripoxvirus, globally result in significant production losses. To improve understanding disease pathogenesis evaluate host species preferences, sheep goats were inoculated either with a capripoxvirus isolate from Yemen or recent outbreak Vietnam. Blood, swabs tissues collected at various time points following experimental challenge assessed for viral DNA content using real-time PCR infectivity virus isolation. The was...
ABSTRACT Lumpy skin disease (LSD) in cattle is managed through live-attenuated vaccines. Bangladesh LSD vaccine was developed from virus isolate LSD-29 by passaging 60 times cell culture. Here, we report the complete genome sequence of strain.
Sheeppox, goatpox, and lumpy skin disease continue to negatively impact the sheep, goat, cattle industries in countries where these diseases are present threaten spread into new regions. Effective vaccines available for control eradication. However, commercial based on live attenuated virus isolates therefore it is not currently possible differentiate between infected vaccinated animals (DIVA), which severely limits use of that free from at risk an incursion. The development next-generation...
Hendra virus (HeV) is a bat-borne zoonotic agent which can cause severe and highly fatal disease be transferred from animals to humans. It has caused over 100 deaths in horses since it was discovered 1994. Four out of seven infected humans have died. Since the release HeV vaccine (Equivac® Virus Vaccine for Horses, Zoetis Australia Pty Ltd., Rhodes, NSW 2138) Australia, there been an urgent requirement serological test differentiating vaccinated (DIVA). All first-line diagnostic assays at...
The genome of the avian pathogen Mycoplasma gallisepticum contains a number related genes for putative adhesion molecules (pMGA). Cloning and sequence analysis several pMGA suggested that all them might be transcriptionally translationally functional. Analysis gene encoding sole variant expressed in vitro S6 strain (pMGA1.1) revealed no unambiguous feature could account its unique expression. It is estimated family may contain up to 50 members, possible role discussed herein.
An ovine testis cell line (OA3.Ts) was evaluated and compared with primary lamb kidney (LK) cells for its utility in capripoxvirus propagation titration. A comparison of OA3.Ts growth kinetics morphology at low (<33) high (34−36) passage levels indicated a difference both characteristics. However, viral titers determined were comparable those obtained using LK cells. Capripoxvirus infection resulted similar cytopathic effect, which allowed the detection discrete plaques following...
Background Influenza A (flu) virus causes significant morbidity and mortality worldwide, current vaccines require annual updating to protect against the rapidly arising antigenic variations due shift drift. In fact, subunit or split flu rely exclusively on antibody responses for protection do not induce cytotoxic T (Tc) cell responses, which are broadly cross-reactive between strains. We have previously reported that γ-ray inactivated can Tc responses. Methodology/Principal Finding Here, we...
Emerging viral diseases have become a significant concern due to their potential consequences for animal and environmental health. Over the past few decades, it has clear that viruses emerging in wildlife may pose major threat vulnerable or endangered species. Diphtheritic stomatitis, likely be caused by an avipoxvirus, been recognised as cause of mortality yellow-eyed penguin (Megadyptes antipodes) New Zealand. However, avipoxvirus infects penguins remained uncharacterised. Here, we report...
This study is the first report of experimental infection and transmission Menangle virus (MenPV) in pigs. Isolated 1997 from piglets that were stillborn at a large commercial piggery New South Wales, Australia, MenPV recently identified paramyxovirus bat origin causes severe reproductive disease pigs an influenza-like illness, with rash, humans. Although successfully eradicated infected piggery, was only isolated affected fetuses during period disease, thus mode between not established. To...
Marine bird populations have been declining globally with the factors driving this decline not fully understood. Viral diseases, including those caused by poxviruses, are a concern for endangered seabird species. In study we characterised novel avipoxvirus, tentatively designated albatrosspox virus (ALPV), isolated from skin lesion of an New Zealand northern royal albatross (Diomedea sanfordi). The ALPV genome was 351.9 kbp in length and contained 336 predicted genes, seven which were...
A universal influenza vaccine that does not require annual reformulation would have clear advantages over the currently approved seasonal vaccine. In this study, we combined mucosal adjuvant alpha-galactosylceramide (αGalCer) and peptides designed across highly conserved precursor haemagglutinin (HA(0)) cleavage loop as a Peptides HA(0) of A/H3N2 viruses, delivered to mice via intranasal route with αGalCer an adjuvant, provided 100 % protection following H3N2 virus challenge. Similarly,...
ABSTRACT Lumpy skin disease (LSD) is an economically devasting and vector-borne transboundary of cattle caused by lumpy virus (LSDV). Here, we report the complete genome sequence outbreak isolate LSDV from Bangladesh. Bangladesh LSD-29 was detected in nodule samples LSD-infected bovine 2021.