A5061252649- Cardiac Fibrosis and Remodeling
- Studies on Chitinases and Chitosanases
- Anesthesia and Neurotoxicity Research
- Signaling Pathways in Disease
- Vitamin C and Antioxidants Research
- Cardiac and Coronary Surgery Techniques
- HIV/AIDS Research and Interventions
- Cardiac Ischemia and Reperfusion
- Cholesterol and Lipid Metabolism
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- Tissue Engineering and Regenerative Medicine
- Inflammasome and immune disorders
- Invertebrate Immune Response Mechanisms
- Systemic Lupus Erythematosus Research
- Cardiac Structural Anomalies and Repair
- HIV Research and Treatment
- Intensive Care Unit Cognitive Disorders
- Atherosclerosis and Cardiovascular Diseases
University of Hawaiʻi at Mānoa
2019-2024
To determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis.Using a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with Ldlr-/- provided us means to investigate effects context atherosclerosis. In vitro, by murine enhanced protein expression IL-4, IL-8, G-CSF BMDM upon stimulation combination lipopolysaccharide (LPS) interferon-γ (IFN-γ). Phosphorylation...
Abstract Macrophage is the predominant cell type in all phases of atherosclerosis and it plays a major role disease progression. Although mammals have no endogenous chitin, macrophages produce chitotriosidase-1 (CHIT1) as part innate immune response various inflammatory conditions including atherosclerosis. We aimed to investigate mechanisms by which CHIT1 may modulate progression using CHIT1-overexpressing, Ldlr−/− mice, also determine whether overexpression affects morphology...
Abstract Increased risk of atherosclerotic cardiovascular diseases is common in HIV+ adults on stable antiretroviral treatment (ART). A key step the development plaque transmigration monocytes to area and their differentiation into macrophages eventually foam cells. The objective this study was determine if propensity transmigrate as well ability take up efflux cholesterol affected by HIV infection. Monocytes (transmigration) differentiated (lipid metabolism) from ART treated patients were...