A5080058805- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Ion channel regulation and function
- HIV Research and Treatment
- HIV-related health complications and treatments
- Parkinson's Disease Mechanisms and Treatments
- Ion Transport and Channel Regulation
- Cardiac Structural Anomalies and Repair
- Cardiac Fibrosis and Remodeling
- Vitamin C and Antioxidants Research
- Long-Term Effects of COVID-19
- Essential Oils and Antimicrobial Activity
- Adipokines, Inflammation, and Metabolic Diseases
- Ion Channels and Receptors
- Lysosomal Storage Disorders Research
- Tissue Engineering and Regenerative Medicine
- Cell Image Analysis Techniques
- Platelet Disorders and Treatments
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- HIV/AIDS Research and Interventions
University of Hawaiʻi at Mānoa
2020-2023
Instituto de Investigación Sanitaria Aragón
2017-2020
Instituto Aragonés de Ciencias de la Salud
2019-2020
Hospital Universitario Miguel Servet
2019
Universidad de Zaragoza
2017
Hospital Universitario Puerta de Hierro Majadahonda
1991
Background TRPV4 channels are calcium-permeable cation that activated by several physicochemical stimuli. Accordingly, have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether is also mechanistically melanoma cell proliferation not clear. Here, we hypothesized expressed human pharmacological activation interferes with proliferation. Methodology/Principal findings functions were studied lines (A375,...
The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K+-efflux, cell volume membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of omega-3 fatty acids as negative modulators impaired functions in the inherited lysosomal storage disorder (LSD), Fabry disease (FD). In first part present study, we characterize murine human fibroblasts test impact on fibroblast proliferation. second, study whether is altered LSDs, FD...
Abstract: The epithelial intermediate-conductance calcium/calmodulin-regulated KCa3.1 channel is considered to be a regulator of intestine function by controlling chloride secretion and water/salt balance. Yet, little known about the functional importance in intestinal epithelium vivo. Our objective was determine impact epithelial-specific inducible overexpression transgene (KCa3.1+) suppression (KCa3.1-) on homeostasis mice. duodenal doxycycline (DOX)-treated KCa3.1+ mice 40-fold above...
Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences genetically encoded induction cell volume-regulating Ca2+-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring KCa3.1+-transgene under control reverse tetracycline-sensitive transactivator (rtTA) showed 800-fold overexpression above basal levels in and solid KCa3.1-currents keratinocytes. This resulted spongiosis,...
ABSTRACT Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences genetically encoded induction cell volume-regulating Ca 2+ -activated KCa3.1 channel ( Kcnn4 ) for murine epidermal homeostasis. Doxycycline-treated mice harboring KCa3.1+-transgene under control reverse tetracycline-sensitive transactivator (rtTA) showed 800-fold overexpression above basal levels in and solid KCa3.1-currents keratinocytes. This resulted...
Abstract Increased risk of atherosclerotic cardiovascular diseases is common in HIV+ adults on stable antiretroviral treatment (ART). A key step the development plaque transmigration monocytes to area and their differentiation into macrophages eventually foam cells. The objective this study was determine if propensity transmigrate as well ability take up efflux cholesterol affected by HIV infection. Monocytes (transmigration) differentiated (lipid metabolism) from ART treated patients were...