A5048946863- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Inflammatory Bowel Disease
- Glioma Diagnosis and Treatment
- Sinusitis and nasal conditions
- Neonatal and fetal brain pathology
- Melanoma and MAPK Pathways
- Esophageal and GI Pathology
- Aluminum toxicity and tolerance in plants and animals
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Trace Elements in Health
- Ophthalmology and Eye Disorders
- Advanced Breast Cancer Therapies
- Metabolomics and Mass Spectrometry Studies
- Ocular Surface and Contact Lens
- Computational Drug Discovery Methods
- Mycobacterium research and diagnosis
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
Case Western Reserve University
2023-2025
University School
2023-2025
L V Prasad Eye Institute
2024
National Center for Toxicological Research
2021-2022
United States Food and Drug Administration
2022
Aravind Eye Hospital
2022
Creative Commons
2022
Background Endoscopic sinus surgery (ESS) is a minimally invasive procedure indicated for medically refractory chronic sinusitis (CRS). As with any surgical procedure, there are potential risks and complications. Objective The purpose of this study to report skull base, orbital, hemorrhagic-associated complication rates following ESS. Methods A retrospective query on the TriNetX platform identified patients diagnosed CRS who subsequently underwent ESS in last 20 years. Outcomes analyses were...
Abstract Background Over the past decade, novel immune checkpoint inhibitors have revolutionized melanoma treatment. These new therapies are associated with complex immune-related adverse events. This study examines whether combination anti-PD-1/CTLA-4 immunotherapy for is increased incidence of neurologic irAEs (n-irAEs) compared to anti-PD-1 monotherapy. Methods A retrospective, multicenter using TriNetX identified adult patients receiving monotherapy (pembrolizumab or nivolumab) [Cohort...
Abstract Purpose: To study the clinical outcomes of descemet stripping automated endothelial keratoplasty (DSAEK) with pre-cut lenticules thickness above 150 microns. Methods: During period Jan 2019 to Sept 2020, 1865 DSAEK were prepared at institute-affiliated eye bank by two trained technicians. Of these, 28 (1.5%) grafts had a >150 microns and utilized institute. Retrospective review medical records was performed for these patients. Results: Median donor age 39 (range, 20–62) years,...
Abstract Objective The risk of hydrocephalus following hemispherectomy for drug resistant epilepsy (DRE) remains high. Patients with pre-existing pose a postoperative challenge, as maintaining existing shunt patency is necessary but lacks clearly defined strategy. This study examines the incidence and predictors failure in pediatric patients ventricular shunts. Methods We performed retrospective chart review at our center to identify diagnosed DRE who were treated prior their first surgery....
This study was conducted to assess the outcomes of bleb needling for treatment failure filtration surgeries in primary glaucoma with a follow-up six months.This prospective interventional included patients who underwent trabeculectomy or combined and cataract surgery failed failing after weeks less than two years. A comprehensive examination including best-corrected visual acuity (BCVA), intraocular pressure (IOP) measurement, gonioscopy, slit-lamp examination, morphology grading done....
Abstract In the past decade, FDA approval of several novel immune checkpoint inhibitors (ICI) has revolutionized treatment advanced melanoma. However, severe immune-related adverse events (irAEs) from these medications have been reported. This study examines whether PD-1/CTLA-4 inhibitor combination immunotherapy confers increased incidence neurologic irAEs in melanoma patients compared to PD-1 monotherapy. A retrospective, multicenter cohort performed using TriNetX research platform...
Abstract The discovery of the neural glymphatic network in past decade has significant implications for clinical investigations on hydrocephalus. With emerging understanding how meningeal lymphatics and perivascular pathways impact cerebrospinal fluid dynamics, it is conceivable that inflammatory fibrotic changes induced by radiation chemotherapy may contribute to pathogenesis postoperative hydrocephalus, a well-documented sequela resective neurosurgery. This study investigates differences...
<title>Abstract</title> <bold>PURPOSE:</bold> This study aims to report a case of HSV keratitis post-Descemet’s stripping automated endothelial keratoplasty (DSAEK) <bold>METHODS:</bold> A 69-year-old male presented with right eye defective vision in the last 1 year. He had poor visual recovery after he underwent cataract surgery year ago. On examination, an old Descemet membrane detachment taut membrane. RE DSAEK, on postoperative day 15 came complaints foreign body sensation, and was...
Key points IBD patients have a 4.04‐fold elevated likelihood of having CRS compared to non‐IBD patients. 4.23‐fold non‐CRS The risk development after is five times higher than CRS.
Abstract Objective: The risk of hydrocephalus following hemispherectomy for drug resistant epilepsy (DRE) remains high. Patients with pre-existing pose a post-operative challenge, as maintaining existing shunt patency is necessary but lacks clearly defined strategy. This study examines incidence and predictors failure in pediatric patients ventricular shunts. Methods: We performed retrospective chart review at our center to identify diagnosed DRE who were treated prior their first surgery....
Background: Paradoxical adverse events (PAEs) have emerged as a well-recognized phenomenon in individuals undergoing biological treatment for chronic immune-mediated disorders. Dermatologic, ocular, and gastrointestinal issues been documented side effects of agents targeting tumor necrosis factor-alpha (TNF-α). Potential pathophysiological mechanisms underlying PAEs include cytokine dysregulation, variations immunological characteristics monoclonal antibodies soluble TNF-α receptors,...