A5043474559- Epilepsy research and treatment
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Complex Systems and Time Series Analysis
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Chaos control and synchronization
- Fractal and DNA sequence analysis
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and Wakefulness Research
- stochastic dynamics and bifurcation
- Nonlinear Dynamics and Pattern Formation
- Anatomy and Medical Technology
- Fetal and Pediatric Neurological Disorders
- History of Medical Practice
- Neurology and Historical Studies
Cleveland Clinic Lerner College of Medicine
2024-2025
Case Western Reserve University
2024-2025
Cleveland Clinic
2012-2025
University School
2024
The Neurological Institute
2012-2024
Neurological Surgery
2024
University of Toronto
2005-2021
Hospital for Sick Children
2005-2021
SickKids Foundation
2005-2021
CancerCare Manitoba
2021
The authors prospectively assessed the value of awake craniotomy used nonselectively in patients undergoing resection supratentorial tumors.The demographic features, presenting symptoms, tumor location, histological diagnosis, outcomes, and complications were documented for 610 who underwent resection. Intraoperative brain mapping was 511 cases (83.8%). Mapping identified eloquent cortex 115 (22.5%) no 396 (77.5%).Neurological deficits occurred 89 (14.6%). In subset whom performed, 78...
We present a fully differential 128-channel integrated neural interface. It consists of an array 8 X 16 low-power low-noise signal-recording and generation circuits for electrical activity monitoring stimulation, respectively. The recording channel has two stages signal amplification conditioning with 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). total measured power consumption each channel, including the SAR ADC, is 15.5 ¿W. input-referred noise 6.08...
A 3D microsystem for multi-site penetrating extracellular neural recording from the brain is presented. 16 times 16-channel interface integrated prototype fabricated in 0.35 mum CMOS occupies 3.5 mm 4.5 area. Each channel dissipates 15 muW of power with input-referred noise 7 muV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> over 5 kHz bandwidth. switched-capacitor delta read-out data compression circuit trades accuracy output rate....
Object Stereoelectroencephalography (SEEG) is a methodology that permits accurate 3D in vivo electroclinical recordings of epileptiform activity. Among other general indications for invasive intracranial electroencephalography (EEG) monitoring, its advantages include access to deep cortical structures, ability localize the epileptogenic zone when subdural grids have failed do so, and utility context possible multifocal seizure onsets with need bihemispheric explorations. In this context,...
Abstract The somato-cognitive action network (SCAN) consists of three nodes interspersed within Penfield’s motor effector regions. configuration the resembles one ‘plis de passage’ central sulcus: small gyri bridging precentral and postcentral gyri. Thus, we hypothesize that these may provide a structural substrate network. Here, using microdissections sixteen human hemispheres, consistently identified chain distinct plis passage with increased underlying white matter, in locations analogous...
Received: 19 December 2024 Accepted after revision: 16 March 2025 Manuscript online:17
This paper is an up-to-date survey of the state art in dynamical systems theory relevant to high levels complexity, characterizing chaos and near-chaos, as commonly found physical sciences. The also surveys applications economics finance. does not include bifurcation analyses at lower such Hopf transcritical bifurcations, which arise closer stable region parameter space. We discuss geometric approach (based on differential/difference equations) make basic notions chaos, other related...
Object The authors review their experience with massive plexiform neurofibromas (PNs) in patients pediatric neurofibromatosis Type 1 (NF1) to better characterize the natural history and management of these complex lesions. Methods performed a retrospective data obtained seven NF1 whom PNs were diagnosed at Hospital for Sick Children Toronto, Ontario, Canada. These attended routine follow-up examinations conducted by number specialists, serial neuroimaging studies monitor disease progression....
We developed, tested, and validated a novel, noninvasive, Leksell G frame-based fiducial attachment, for use in stereotactic registration stereoelectroencephalography (sEEG). Use of the device increased number fixed reference points available registration, while obviating need additional scalp incisions. report here on our experience safety profile using device.
Most forms of epilepsy are marked by seizure episodes that arise spontaneously. The low-magnesium/high-potassium (low-Mg2+/high-K+) experimental model is an acute produces spontaneous, recurring seizure-like events (SLEs). To elucidate the nature spontaneous transitions and their relationship to neuronal excitability, whole-cell recordings from intact hippocampus were undertaken in vitro, response hippocampal CA3 neurons Gaussian white noise injection was obtained before after treatment with...
Fractal methods offer an invaluable means of investigating turbulent nonlinearity in non-stationary biomedical recordings from the brain. Here, we investigate properties complexity (i.e. correlation dimension, maximum Lyapunov exponent, 1/fγ noise and approximate entropy) multifractality background neuronal noise-like activity underlying epileptiform transitions recorded at intracellular local network scales two vitro models: whole-intact mouse hippocampus lesional human hippocampal slices....
Organized brain activity is the result of dynamical, segregated neuronal signals that may be used to investigate synchronization effects using sophisticated neuroengineering techniques. Phase synchrony analysis, in particular, has emerged as a promising methodology study transient and frequency-specific coupling across multi-site signals. In this study, we investigated phase intracellular recordings interictal ictal epileptiform events recorded from pairs cells whole (intact) mouse...
Surgery for frontal lobe epilepsy often has poor results, likely because of incomplete resection the epileptogenic zone.To present our experience with a series patients manifesting 2 different anatomo-electro-clinical patterns refractory orbitofrontal epilepsy, necessitating surgical approaches in each group.Eleven involving region were consecutively identified over 3 years whom stereoelectroencephalography zone. All underwent preoperative evaluation, stereoelectroencephalography, and...
In this paper the authors trace history of early craniometry, referring to technique obtaining cranial measurements for accurate correlation external skull landmarks specific brain regions. Largely drawing on methods from newly emerging fields physical anthropology and phrenology in late 19th 20th centuries, basic mathematical concepts were combined with simplistic (yet at time, innovative) mechanical tools, leading first known attempts craniocerebral topography. It is important acknowledge...
Abstract Study Objectives Rapid eye movement sleep (REM) usually suppresses interictal epileptiform discharges (IED) and seizures. However, breakthrough IEDs in REM sometimes continue. We aimed to determine if the amount of IED seizures REM, or duration, is associated with clinical trajectories. Methods Continuous electroencephalogram (EEG) recordings from epilepsy monitoring unit (EMU) were clipped at least 3 h concatenated salient findings per day including all identified REM. Concatenated...
Abstract Objective The risk of hydrocephalus following hemispherectomy for drug resistant epilepsy (DRE) remains high. Patients with pre-existing pose a postoperative challenge, as maintaining existing shunt patency is necessary but lacks clearly defined strategy. This study examines the incidence and predictors failure in pediatric patients ventricular shunts. Methods We performed retrospective chart review at our center to identify diagnosed DRE who were treated prior their first surgery....
Ictal Single Photon Emission Computed Tomography (SPECT) and stereo-electroencephalography (SEEG) are diagnostic techniques used for the management of patients with drug-resistant focal epilepsies. While hyperperfusion patterns in ictal SPECT studies reveal seizure onset propagation pathways, role hypoperfusion remains poorly understood. The goal this study was to systematically characterize spatio-temporal information flow dynamics between differently perfused brain regions using stereo-EEG...