A5016449904- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Neonatal and fetal brain pathology
- Peripheral Neuropathies and Disorders
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Amino Acid Enzymes and Metabolism
- Diabetes Management and Research
- Vitamin D Research Studies
- Migraine and Headache Studies
- Cardiovascular Syncope and Autonomic Disorders
- Multiple Sclerosis Research Studies
- Neurological and metabolic disorders
- Neuroblastoma Research and Treatments
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Cystic Fibrosis Research Advances
- Myasthenia Gravis and Thymoma
- Child Nutrition and Feeding Issues
- Genomics and Rare Diseases
- Neonatal Respiratory Health Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dermatoglyphics and Human Traits
- Ottoman and Turkish Studies
Usak University
2025
Adnan Menderes University
2021-2025
Dokuz Eylül University
2014-2023
Istanbul Aydın University
2021-2022
Sivas Cumhuriyet Üniversitesi
2021
Sivas State Hospital
2020
Abstract The purpose of this study was to enhance understanding CACNA1A gene variants by elucidating the clinical profiles patients with different variants. overlapping features and varying phenotypic characteristics these neurological disorders pose challenges for clinicians. A data collection form utilized gather features, examination details, treatment information associated Thirty-one were included in from 11 clinics Turkey. Cases assessed comparing their existing literature. initially...
Congenital myasthenic syndromes are clinically and genetically heterogeneous disorders of neuromuscular transmission. Most treatable, but certain subtypes worsen with cholinesterase inhibitors. This underlines the importance genetic diagnosis. Here, authors report on cases proven congenital from Turkey. The retrospectively reviewed their experience all patients syndromes, referred over a 5-year period (2011-2016) to Child Neurology Department Dokuz Eylül University, Izmir, In addition,...
In up to 20% of epilepsy patients, seizures may not be controlled despite the use antiepileptic drugs, either alone or in combination. These individuals are considered have drug-resistant epilepsy. Drug-resistant is usually associated with intellectual disability, psychiatric comorbidity, physical injury, sudden unexpected death, and low quality life. Early detection prediction essential determining patient’s most appropriate treatment option. This retrospective study aimed determine...
Myelin oligodendrocyte glycoprotein (MOG) is a candidate target antigen in demyelinating central nervous system diseases, including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica, and multiple sclerosis. It may give prognostic information regarding monophasic or recurrent course of the disease. MOG antibodies have been shown to be positive high titers during first episode ADEM with rapidly decreasing undetectable limits after recovery. However, persistent are considered as...
We present a four-year-old wth ethylmalonic encephalopathy who presented with delayed walking. She had bilateral hyperintense lesions in the basal ganglia. Molecular analysis revealed homozygous c.3G>T mutation ETHE1 gene. did not have typical findings of disease including recurrent petechia, chronic diarrhea and acrocyanosis was very subtle orthostatic. benefited from riboflavine Q10 treatments. suggest that should be questioned examined patients motor delay.
Seizures are the most frequent neurological disturbance in neonatal period, and there no evidence-based guidelines for treatment of seizures. Here we report a study on use levetiracetam as second-line therapy seizures term preterm neonates.The aim this was to assess efficacy safety neonates.We retrospectively analyzed data patients who had were treated with an add-on phenobarbital during period.The Statistical Package Social Sciences (SPSS) software, version 15.0 (SPSS, Chicago, Illinois),...
OBJECTIVE: Vitamin D deficiency has been implicated in children using antiepileptic drugs. Multiple drugs may increase the risk of vitamin deficiency. The aim this study is to evaluate status and factors for with refractory epilepsy. METHODS: Forty epilepsy seen our tertiary pediatric neurology outpatient clinic were included serum 25-hydroxy D, parathyroid hormone, calcium, phosphate alkaline phosphatase measured. was defined as levels <20 ng/mL, insufficiency between 21 29 ng/mL....
Introduction: Febrile seizures (FS) are the most frequently encountered childhood neurological problems.They cause stress and anxiety for parents a considerable workload healthcare providers.The purpose of this study was to identify useful markers capable predicting risk FS in febrile children with upper respiratory infection using complete blood count parameters.Methods: Four hundred seventy-six aged between 6 months 5 years, 240 history first FS, 121 acute tract without (AFI), 115 healthy...
Objective: Primary headaches are common and benign discomforts both in children adolescents. However, they have a negative influence on the quality of life. This retrospective study aimed to determine relationship between vitamin B12 results primary Turkish children. Methods: Demographical features, headache types, laboratory results, including B12, were assessed retrospectively. Headache types categorized as tension-type headache, migraine, unclassified according International...
Aim: To evaluate i) the relationship between epilepsy and inflammation by analyzing levels of thymus activation-regulated chemokine (TARC), interferon regulatory factor 5 (IRF5) in healthy controls, patients with on monotherapy polytherapy, ii) sICAM5, (c-x3-c motif) ligand 1 (CX3CL1), septin 7 (SEPT7) which are important both synaptic formation.Methods: Patients who were seizure-free (epilepsy group-1), drug-resistant group-2), controls included. Demographical data, disease durations,...
Amaç: Otistik spektrum bozukluğunda (OSB) epilepsi ve elektroensefalografi (EEG) anormallikleri daha sık görülmektedir.Biz de kliniğimizde OSB ile izlenen EEG incelemesi olan olgularda epilepsi, nöbet varlığına neden risk faktörlerini
Mutations in the genes encoding voltage-gated sodium channels cause a variety of epilepsy syndromes, with most mutations occurring SCN1A gene. It is one well-researched genes. The gene, which seems to be relevant regulator excitability CNS, implicated various phenotypes through genetic mechanisms ranging from common variants rare monogenic variants. known that gene tightly linked severe myoclonic infancy (SMEI). However, its phenotypic spectrum expanding. Here, we report clinical and...
Aim: The lifestyle and environmental changes associated with industrialization urbanization are crucial factors in determining the prevalence of allergic diseases. Material Methods: aim this study was to determine asthma other disorders an industrial town.Study Design: Prospective, Cross-sectional study. This cross-sectional population-based conducted Kemalpasa, Ýzmir, Turkey, which is town. Using International Study Asthma Allergies Childhood (ISAAC), questionnaire carried out on 1511...
Objectives: To analyze the clinical features of prolonged seizures and status epilepticus perform risk analysis on super refractory (SRSE) in pediatric intensive care unit (PICU) admissions. Method: Demographic features, underlying etiologies, treatment modalities, electroencephalographic neuroimaging outcome admissions between 2015 2019 were analyzed. Results: Seventy-one children enrolled. The common etiology for seizure was fever 45.1% (central nervous system infection: 16.9%, infection...
Aim: This is a unique study that aimed to determine anemia and inflammatory status in simple febrile seizure vs complex febrileseizure patients. Neutrophil/lymphocyte ratio platelet/lymphocyte are positively correlated with markersincluding TNF alpha IL-6. They practical, inexpensive, valuable tools for evaluating inflammation.Materials Methods: Patients presenting first seizures were enrolled retrospectively. We investigated hemoglobin,hematocrit, mean corpuscular volume, hemoglobin...