A5024071857- Ion channel regulation and function
- Safe Handling of Antineoplastic Drugs
- Plant-based Medicinal Research
- Virus-based gene therapy research
- Cardiac electrophysiology and arrhythmias
- Childhood Cancer Survivors' Quality of Life
- Effects of Radiation Exposure
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Erythrocyte Function and Pathophysiology
- Pharmaceutical studies and practices
- CRISPR and Genetic Engineering
- Carcinogens and Genotoxicity Assessment
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Garlic and Onion Studies
- Heart Failure Treatment and Management
- Radiation Therapy and Dosimetry
- Cancer-related Molecular Pathways
- Phytochemicals and Antioxidant Activities
- Chemical synthesis and alkaloids
- Synthesis and Biological Activity
- Neuropeptides and Animal Physiology
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
Daiichi University of Pharmacy
2024
Hiroshima University Hospital
2018-2023
University Hospital of Basel
2023
Hiroshima University
2020-2022
Kyushu University
2019-2021
Waseda University
2019
Kyushu University Hospital
2018
University of Miyazaki
2015-2016
Kobe Pharmaceutical University
1995-2009
NTL Institute for Applied Behavioral Science
2003-2009
Summary This study tested the feasibility of oral immunotherapy for bronchial asthma using a newly developed subunit vaccine in which fragment (p45–145) mite allergen (Der p 1) containing immunodominant human and mouse T cell epitopes was encapsulated endoplasmic reticulum‐derived protein bodies transgenic (Tg) rice seed. Allergen‐specific serum immunoglobulin responses, proliferation, Th1/Th2 cytokine production, airway inflammatory infiltration, hyper‐responsiveness (BHR) lung histology...
Ring structure−reactivity relationships of three flavan-3-ols [epicatechin (EC), epicatechin gallate (ECG), and epigallocatechin (EGCG)] simple phenolic compounds (1,3,5-trihydroxybenzene, 1,2,3-trihydroxybenzene, methylgallate as the analogous individual A, B, C benzene rings EGCG) on product generation in an aqueous glucose−glycine reaction model system (125 °C 30 min) were investigated. The addition EC, ECG, or EGCG to a was reported similarly significantly reduce formation pyrazine,...
Background. We investigated the potential safety of remimazolam and propofol in malignant hyperthermia- (HM-) susceptible patients using ryanodine receptor 1- (RYR1-) expressing human embryonic kidney- (HEK-) 293 cells. Methods. compared enhanced responsiveness HEK-293 cells wild-type RYR1 with that mutant to caffeine following perfusion or propofol. Furthermore, we whether median effective concentration (EC50; i.e., required reach half-maximal activation) an unpaired two-tailed <math...
The accurate regulation of phosphorylation at the kinetochore is essential for establishing chromosome bi-orientation. Phosphorylation proteins by Aurora B kinase destabilizes improper kinetochore–microtubule attachments, whereas phosphatase PP2A has a counteracting role. Imbalanced phosphoregulation leads to error-prone segregation and aneuploidy, hallmark cancer cells. However, little known about molecular events that control balance kinetochore. Here, we show localization SET/TAF1, an...
Deletion mutations were efficiently recovered in mouse liver after total-body irradiation with X rays by using a transgenic "gpt-delta" system that harbored lambda EG10 shuttle vector the red and gam genes for Spi- (sensitive to P2 lysogen interference) selection. We incorporated this into homozygous Atm-knockout mice as model of radiosensitive hereditary disease ataxia telangiectasia (AT). Lambda phages from livers X-irradiated Atm+/+ genotype showed dose-dependent increase mutant frequency...
Remimazolam is a novel general anesthetic and its safety in patients with malignant hyperthermia (MH) unknown. We used myotubes derived from the skeletal muscle of MH to examine response ryanodine receptor 1 (RYR1) agonist remimazolam MH-susceptible patients. Patients underwent biopsy for Ca2+-induced Ca2+ release (CICR) rate test, diagnostic tool Japan. Ten had obtained cultures, genes associated these were analyzed. The EC50 caffeine, cresol, induce intracellular calcium concentration...
Malignant hyperthermia is a pharmacogenetic disorder triggered by halogenated anesthetic agents in genetically predisposed individuals. Approximately 70 % of these individuals carry mutations RYR1, the gene encoding ryanodine receptor calcium channel skeletal muscle. In this study, we performed functional analysis 5 RYR1 variants identified members from 8 families who had been diagnosed IVCT. Of 68 enrolled 43 were as MHS, 23 MHN, and 2 not tested. Here demonstrate that RyR1 cause...
Dantrolene is currently the only drug known to specifically treat malignant hyperthermia (MH) crises. Although dantrolene attenuates Ca2+ disorders by acting mainly on ryanodine receptor type 1 (RYR1), some patients who manifest MH without RYR1 variants have also been successfully treated with dantrolene. Thus, appears an inhibitory effect and variants. This study aimed investigate whether effects of differed depending presence or absence using muscle cells from MH-predisposed individuals....
Background and aims : Severe aortic stenosis (AS) has been normally treated with surgical valve replacement (AVR) whereas recently, transcatheter implantation (TAVI) introduced as a minimally invasive operation for patients high risk frailty. In this study, we have evaluated postoperative physical function nutrition intake in the following AVR TAVI. Methods This prospective observational study involved 9 7 (TAVI). Body composition was measured one day prior surgery, (POD) 1, POD 3, 5 7. Hand...
Abstract The crystal structure of (±)‐corynoline ( 1 ) has been determined by X‐ray diffraction methods. rings B and C form the half‐chair twist‐half‐chair conformations, respectively. B/C ring conjunction exists in an anti ‐ cis conformation, with a N …︁ HO intramolecular H‐bond. Conformational energy calculation CNDO/2 method show that conformations , (+)‐chelidonine 2 ), their acetates, observed structures, are all one total minimum.
The effects of chronic administration naloxone (120-150μg•kg-1•h-1) on the wheel running activity (WR) and food water intakes were studied in male Wistar rats subjected to a 2-h restricted feeding (1200-1400h) schedule at 24±1°C LD 12:12 (L: 0600-1800h) cycle. significantly increased WR before after time. Food per day reduced body weight gradually decreased for 2-week restriction period. appeared be suppressed by naloxone, particularly shortly administration. chronically administered...
Background: It is unclear whether the doses of opioids and routes administration used for postoperative analgesic management are associated with delirium. We aimed to compare incidence delirium (POD) between intravenous patient-controlled analgesia (IVPCA) epidural (PCEA) in patients who underwent using opioids. Methods: retrospectively investigated surgical (n=3,324) received (PCA). Morphine was IVPCA, fentanyl ropivacaine were PCEA. The patients' background characteristics, perioperative...