A5017384612- Bipolar Disorder and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Adolescent and Pediatric Healthcare
- Suicide and Self-Harm Studies
- Sleep and related disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Schizophrenia research and treatment
- Mental Health Research Topics
- Family Support in Illness
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Medication Adherence and Compliance
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Family Caregiving in Mental Illness
- Circadian rhythm and melatonin
- Child Development and Digital Technology
- Stuttering Research and Treatment
- Child Nutrition and Feeding Issues
- Advanced Neuroimaging Techniques and Applications
- Perfectionism, Procrastination, Anxiety Studies
- Personality Disorders and Psychopathology
- Resilience and Mental Health
Western Pennsylvania Hospital
2021-2025
University of Pittsburgh
2016-2025
Psychiatric Medical Center
2025
University of Pittsburgh Medical Center
2014-2024
Neuroscience Research Australia
2023
Dalhousie University
2023
Brown University
2014-2023
Massachusetts Mental Health Center
2023
Beth Israel Deaconess Medical Center
2023
Mercy Hospital
2021
Objective: The authors sought to identify diagnostic risk factors of manic, mixed, or hypomanic episodes in the offspring parents with bipolar disorder (“high-risk offspring”). Method: High-risk 6–18 years old (N=391) and demographically matched (N=248) community without were assessed longitudinally standardized instruments by staff blind parental diagnoses. Follow-up assessments completed 91% (mean follow-up interval, 2.5 years; mean duration, 6.8 years). Results: Compared offspring,...
The authors sought to assess dimensional symptomatic predictors of new-onset bipolar spectrum disorders in youths at familial risk disorder ("at-risk" youths).Offspring 6-18 years old parents with I or II (N=359) and community comparison offspring (N=220) were recruited. At baseline, 8.4% the had a disorder. Over 8 years, 14.7% for whom follow-up data available (44/299) developed (15 disorder). Measures collected baseline reduced using factor analyses, factors (both visit prior conversion...
<h3>Importance</h3> Early identification of individuals at high risk for the onset bipolar spectrum disorder (BPSD) is key from both a clinical and research perspective. While previous work has identified presence prodrome, predictive implications individual have not been assessed, to date. <h3>Objective</h3> To build calculator predict 5-year BPSD in youth familial BPSD. <h3>Design, Setting, Participants</h3> The Pittsburgh Bipolar Offspring Study an ongoing community-based longitudinal...
The purpose of this study was to conduct a pilot randomized trial dialectical behavior therapy (DBT) versus psychosocial treatment as usual (TAU) for adolescents diagnosed with bipolar disorder (BP).We recruited participants 12-18 years age primary BP diagnosis (I, II, or operationalized not otherwise specified [NOS] criteria) from pediatric specialty clinic. Eligible patients were assigned using 2:1 randomization structure either DBT (n=14) TAU (n=6). All received medication management...
Using Apple’s Screen Time application to obtain reported actual iPhone and social media (SM) use, we examined the accuracy of retrospective estimates usage, how inaccuracies bias associations between use psychosocial well-being (depression, loneliness, life satisfaction), degree which were predicted by levels well-being. Among a sample 325 users, found that (a) participants misestimated their weekly overall SM 19.1 12.2 hours, respectively; (b) correlations estimated variables consistently...
Objective The authors sought to identify and evaluate longitudinal mood trajectories associated baseline predictors in youths with bipolar disorder. Method A total of 367 outpatient (mean age, 12.6 years) disorder at least 4 years follow-up were included. After intake, participants interviewed on average 10 times (SD=3.2) over a mean 93 months (SD=8.3). Youths parents for psychopathology, functioning, treatment, familial psychopathology functioning. Results Latent class growth analysis...
Background Identifying proximal risk factors for suicidal ideation that are modifiable and relevant adolescents young adults is critical suicide prevention. This study used an intensive monitoring approach to examine whether objectively‐ subjectively‐ measured sleep characteristics predict next‐day occurrence intensity through affective reactivity interpersonal events in people at high suicide. Methods Participants included 59 (13–23 years; 76% White; 75% female) undergoing outpatient...
Objectives To study the longitudinal course of sleep timing and circadian preferences in individuals with bipolar disorder ( BP ) compared to non‐ psychopathology healthy controls. Methods Individuals I II (n = 257), 105), controls 55) (mean age 40.2 years, 21.3% male, 85.1% Caucasian) were followed on average every 27 months for a mean four years. Sleep parameters preference reported using Timing Questionnaire The Composite Scale Morningness. Group comparisons adjusted multiple...
Objective: To examine medication adherence and associated factors among adolescents with bipolar disorder (BP) using both objective subjective methods. Method: Participants were 21 a primary BP diagnosis recruited from pediatric specialty clinic. All participants prescribed at least one psychotropic medication. Self- parent-reported assessed monthly over 6 months. Objective data on gathered through an electronic weekly pillbox. Demographic clinical self, parent, physician ratings baseline,...
Objectives Disruptions in sleep and dysregulation circadian functioning may represent core abnormalities the pathophysiology of bipolar disorder ( BP ). However, it is not clear whether these dysfunctions are state or trait markers . This report compared phenotypes among three groups: offspring parents with diagnosed at intake / OB ; n = 47), without (non‐ 386), matched control who did have (controls; 301). We also examined association baseline parameters subsequent development non‐ group....
Establishing genetic contributions to the transmission of bipolar disorder (BD) from parents offspring may inform risk developing this and further serve validate BD in youth.To evaluate specific association polygenic scores (PRSs) on familial validity pediatric BD.This community-based case-control longitudinal study (Pittsburgh Biological Offspring Study) included with I/II their without (healthy or non-BD psychopathology) offspring. Participants were recruited between March 2001 May 2007,...
Objective: Family history is an established risk factor for mental illness. The authors sought to investigate whether polygenic scores (PGSs) can complement family improve identification of major mood and psychotic disorders. Methods: Eight cohorts were combined create a sample 1,884 participants ages 2–36 years, including 1,339 offspring parents with or disorders, who prospectively assessed diagnostic interviews over average 5.1 years. PGSs constructed depression, bipolar disorder, anxiety,...
Early-onset bipolar disorder conveys substantial risk for suicide. No psychosocial intervention this population expressly targets suicidal behavior.
ABSTRACT Bipolar disorder (BD) is characterized by temporal instability of mood and energy, but the neural correlates this are poorly understood. In previous cross-sectional studies, state in BD has been associated with differential functional connectivity (FC) amongst several subcortical regions ventromedial prefrontal cortex. Here, we assess whether longitudinal within mood-related network interest (NOI). Young people BD-I/II were scanned 4-6 times healthy controls (HC) 4 over 9 months....
Introduction: Prior studies have demonstrated that, in both adults and youth, bipolar disorder (BD) is a polygenic illness. However, no examined risk scores (PRSs) relation to the longitudinal course of mood symptoms youth with BD. Methods: This study included 246 European ancestry BD (7-20 years old at intake) from Course Outcome Bipolar Youth Centre for Disorder. Mood symptom severity was assessed intake and, 168 participants, prospectively median 8.7 years. PRSs BD, schizophrenia (SCZ),...
In offspring of parents with bipolar or major depressive disorder, we examined the longitudinal association between parents' and youths' ratings family conflict criticism levels impulsive aggression during a 6-month randomized trial intervention. Following diagnostic evaluation, offered adolescents (aged 13-19 years) mood disorders 12-session, 18-week protocol family-focused therapy, random assignment to mobile applications that enabled tracking encouraged practice management communication...
Objective There is substantial interest in delineating the course of cognitive functioning bipolar ( BP ) youth. However, there are no longitudinal studies aimed at defining subgroups youth based on their distinctive trajectories and associated clinical variables. Method Cognitive was measured 135 participants from Course Outcome Youth COBY study using several subtests Cambridge Neuropsychological Test Automated Battery CANTAB ). were prospectively evaluated three times average every 13.75...