A5069692032- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Testicular diseases and treatments
- Biomarkers in Disease Mechanisms
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer-related gene regulation
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
Tokai University
2016-2024
We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B cell lymphoma (DLBCLsn ) in a series 240 cases DLBCL not otherwise specified [DLBCLall (NOS) ], including DLBCLsn training set (n = 11) and validation 18), DLBCLnon-sn 211).In set, 82% had non-germinal center B-cell-like (Hans' Classifier) (non-GCB) phenotype 18% were Epstein-Barr virus-encoded small RNAs (EBER)+ . The genomic profile showed gains(+) 1q21.3q31.2 (55%), 10q24.1 (46%), 11q14.1...
Diffuse large B-cell lymphoma (DLBCL) is one of the most frequent subtypes non-Hodgkin lymphomas. We used artificial neural networks (multilayer perceptron and radial basis function), machine learning, conventional bioinformatics to predict overall survival molecular DLBCL. The series included 106 cases 730 genes a pancancer immune-oncology panel (nCounter) as predictors. multilayer predicted outcome with high accuracy, an area under curve (AUC) 0.98, ranked all according their importance....
The microenvironment influences the behavior of follicular lymphoma (FL) but specific roles immunomodulatory BTLA and TNFRSF14 (HVEM) are unknown. Therefore, we examined their immunohistochemical expression in intrafollicular, interfollicular total histological compartments 106 FL cases (57M/49F; median age 57-years), nine relapsed-FL with transformation to DLBCL (tFL). pattern was T-helper cells (TFH) intrafollicular T-cells compartments. mantle zones were BTLA+ 35.6% similar distribution...
The prognosis of diffuse large B-cell lymphoma (DLBCL) is heterogeneous. Therefore, we aimed to highlight predictive biomarkers. First, artificial intelligence was applied into a discovery series gene expression 414 patients (GSE10846). A dimension reduction algorithm correlate with the overall survival and other clinicopathological variables; included combination Multilayer Perceptron (MLP) Radial Basis Function (RBF) neural networks, gene-set enrichment analysis (GSEA), Cox regression...
Tumor-associated macrophages (TAMs) are associated with a poor prognosis of diffuse large B-cell lymphoma (DLBCL). As heterogeneous, the immune polarization and their pathological role warrant further study. We characterized microenvironment DLBCL by immunohistochemistry in training set 132 cases, which included 10 Epstein-Barr virus-encoded small RNA (EBER)-positive five high-grade lymphomas, gene expression profiling representative subset 37 cases. Diffuse had differential infiltration...
Rheumatoid arthritis patients often develop the diffuse large B-cell lymphoma subtype of methotrexate-associated lymphoproliferative disorder (DLBCL). We characterized genomic profile and pathologic characteristics 20 biopsies using an integrative approach. DLBCL was associated with extranodal involvement, a high/high-intermediate international prognostic index in 53% cases, responded to MTX withdrawal. The phenotype nongerminal center 85% samples Epstein-Barr encoding region positive (EBER)...
Tumor-associated macrophages (TAMs) of the immune microenvironment play an important role in Diffuse Large B-cell Lymphoma (DLBCL) pathogenesis. This research aimed to characterize expression macrophage colony-stimulating factor 1 receptor (CSF1R) at gene and protein level correlation with survival. First, immunohistochemical CSF1R was analyzed a series 198 cases from Tokai University Hospital two patterns histological were found, TAMs, diffuse B-lymphocytes pattern. The clinicopathological...
Objective: We have recently identified using multilayer perceptron analysis (artificial intelligence) a set of 25 genes with prognostic relevance in diffuse large B-cell lymphoma (DLBCL), but the importance this other hematological neoplasia remains unknown. Methods and Results: tested (i.e., ALDOB, ARHGAP19, ARMH3, ATF6B, CACNA1B, DIP2A, EMC9, ENO3, GGA3, KIF23, LPXN, MESD, METTL21A, POLR3H, RAB7A, RPS23, SERPINB8, SFTPC, SNN, SPACA9, SWSAP1, SZRD1, TNFAIP8, WDCP ZSCAN12) series gene...
High expression of the anti-apoptotic TNFAIP8 is associated with poor survival patients diffuse large B-cell lymphoma (DLBCL), and one functions to inhibit pro-apoptosis Caspase-8. We aimed analyze immunohistochemical Caspase-8 (active subunit p18; CASP8) in a series 97 cases DLBCL from Tokai University Hospital, correlate other pathway-related markers, including cleaved Caspase-3, PARP, BCL2, TP53, MDM2, MYC, Ki67, E2F1, CDK6, MYB LMO2. After digital image quantification, correlation...
Follicular lymphoma (FL) is the second most common in Western countries. FL characterized by being incurable, usually having an indolent clinical course with frequent relapses, and eventual patient’s death or transformation to Diffuse Large B-cell Lymphoma. The immune response tumoral microenvironment, including FOXP3+Tregs, PD-1+TFH cells, TNFRSF14 (HVEM), BTLA play a role pathogenesis. We aimed analyze gene expression of Artificial Intelligence (machine learning, deep learning), identify...
Most follicular lymphomas (FL) show t(14;18)/IGH-BCL2 translocation, but rearrangement (R) negative cases exist. A series of 140 FL patients with a BCL2, BCL6, and MYC gene status examined by fluorescence in situ hybridization (FISH) were classified into five groups: (a) BCL2-R group (BCL2-R/BCL6-G/MYC-G) (G, germline), 77 cases; (b) BCL2/BCL6 double-R (BCL2-R/BCL6-R/MYC-G), 16 (c) BCL6-R (BCL2-G/BCL6-R/MYC-G), (d) MYC-R (BCL2-R or G/BCL6-R G/MYC-R), three (e) Triple-G (BCL2-G/BCL6-G/MYC-G),...
Follicular lymphoma (FL) is one of the most frequent subtypes non-Hodgkin lymphomas. This research predicted prognosis 184 untreated follicular patients (LLMPP GSE16131 series), using gene expression data and artificial intelligence (AI) neural networks. A new strategy based on random number generation was used to create 120 different independent multilayer perceptron (MLP) solutions, 22,215 probes were ranked according their averaged normalized importance for predicting overall survival....
Diffuse large B-cell lymphoma with MYC rearrangement is defined as double/triple-hit (DHL/THL) or single-hit (SHL) by the inclusion of BCL2 and BCL6 rearrangements status. DHL/THL called "high-grade and/or rearrangements" in World Health Organization 2017 Classification Tumors Hematopoietic Lymphoid Tissues. To find a prognostic biomarker DHL/THL, we firstly examined 19 cases (molecular analysis series;10 9 SHL) gene expression profile analysis. The showed that high AICDA was associated an...
Diffuse large B-cell lymphoma (DLBCL) with MYC alteration is classified as high-grade and BCL2 and/or BCL6 rearrangements (double/triple-hit lymphoma; DHL/THL), DLBCL rearrangement (single-hit SHL) MYC-cluster amplification (MCAD). To elucidate the genetic features of DHL/THL, SHL, MCAD, 23 cases from Tokai University Hospital were analyzed. The series included 10 SHL 3 MCAD. analysis used whole-genome copy number microarray (OncoScan) a custom-made next-generation sequencing (NGS) panel 115...
Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of 74-year-old male who initially presented right supraclavicular (lymph) node enlargement. Histological analysis showed proliferation spindle-shaped cells narrow cytoplasms. An immunohistochemical panel was used to exclude other tumors, such as melanoma, carcinoma, and sarcoma. The characterized by cell-of-origin subtype germinal center B-cell-like (GCB) based on Hans' classifier...
Abstract We present 2 cases of malignant peritoneal mesothelioma (MPM) characterized by a localized solid mass without ascites and showing 18 F-FDG uptake. A 79-year-old man with history asbestos exposure suffered from an epithelioid MPM originating the hepatoduodenal ligament FDG uptake (SUVmax 16.8). Another 80-year-old esophageal cancer showed desmoplastic small bowel mesentery 4.0). Desmoplastic is more aggressive yields poorer prognosis compared type. However, case mild because rich fibrosis.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Although multilobated subtype DLBCL has been observed since 1970s, little known about clinical significance this unique variant in era rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone/prednisolone (R-CHOP) therapy. In study, retrospective clinicopathological analysis 312 patients diagnosed with showed that group comprised 11% cases and was predominantly male (p = 0.027), achieved complete...