A5032800178- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Asymmetric Synthesis and Catalysis
- Glycogen Storage Diseases and Myoclonus
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Pancreatic function and diabetes
- Organic Chemistry Cycloaddition Reactions
- Molecular spectroscopy and chirality
- Natural product bioactivities and synthesis
- Molecular Sensors and Ion Detection
- Diabetes Treatment and Management
- Microbial Natural Products and Biosynthesis
- Antimicrobial Peptides and Activities
- Traditional and Medicinal Uses of Annonaceae
- Supramolecular Chemistry and Complexes
- Bacteriophages and microbial interactions
- Biochemical and Molecular Research
- Marine Sponges and Natural Products
- Diabetes Management and Research
- Monoclonal and Polyclonal Antibodies Research
- Chemical synthesis and alkaloids
- Steroid Chemistry and Biochemistry
- Synthetic Organic Chemistry Methods
- Diabetes and associated disorders
Novametrics (United Kingdom)
2024
Philips (United Kingdom)
2018
Trinity College Dublin
1992
The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign of Inhibitors Glycogen Phosphorylase: A Study .alpha.- and .beta.-C-Glucosides 1-Thio-.beta.-D-glucose CompoundsKimberly A. Watson, Edward P. Mitchell, Louise N. Johnson, Claire J. F. Bichard, Michael G. Orchard, George W. Fleet, Nikos Oikonomakos, D. Leonidas, Jong Chan Son, Cite this: Biochemistry 1994, 33, 19, 5745–5758Publication Date (Print):May 17, 1994Publication History Published online1 May 2002Published inissue 17...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlucose analog inhibitors of glycogen phosphorylase: the design potential drugs for diabetesJ. L. Martin, K. Veluraja, Ross, N. Johnson, G. W. J. Fleet, Ramsden, I. Bruce, M. Orchard, Oikonomakos, and Cite this: Biochemistry 1991, 30, 42, 10101–10116Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October...
Antibiotic resistance continues to reduce the number of available antibiotics, increasing need for novel antibacterial drugs. Since seminal work Sir Alexander Fleming, antibiotic identification has been based exclusively on inhibition bacterial growth in vitro. Recently, inhibitors virulence which interfere with pathogenesis mechanisms have proposed as an alternative and a few were discovered using assays targeting specific mechanisms. Here we designed simple surrogate host model measurement...
The 'cholaphane'1 was synthesized in 26% overall yield from cholic acid and its structure determined by X-ray crystallography; the molecule adopts an open conformation is able to surround two molecules of tetrahydrofuran.
A second 'cholaphane' framework is manifested in the title compound 8, which has been prepared from methyl 3α,7α, 12α-triacetoxycholanoate 9 23% overall yield. The synthesis involves Knoevenagel condensation of ketone 11 with malononitrile to give dicyanomethylene derivative 12, equatorialselective addition latter an organocuprate derived aryl bromide 15, conversion resulting adduct into amino acid 22, and cyclodimerisation. 8 less conformational freedom a better-defined cavity than...
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”