A5045687571- Mosquito-borne diseases and control
- Metabolomics and Mass Spectrometry Studies
- Nerve injury and regeneration
- Telomeres, Telomerase, and Senescence
- Malaria Research and Control
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Bone and Dental Protein Studies
- Viral Infections and Vectors
- Neurosurgical Procedures and Complications
- Bone health and treatments
- Corneal surgery and disorders
- Neuroblastoma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Proteomics Techniques and Applications
- Bone Metabolism and Diseases
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Calcium signaling and nucleotide metabolism
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Neonatal and Maternal Infections
- Intracerebral and Subarachnoid Hemorrhage Research
- Skin Protection and Aging
- Soft tissue tumor case studies
Buck Institute for Research on Aging
2020-2024
MRC Toxicology Unit
2024
Hartford Hospital
2021-2024
University of Cambridge
2016-2024
Indian Institute of Technology Bombay
2013-2023
University of California, San Diego
2023
Hartford Financial Services (United States)
2021
The University of Texas Medical Branch at Galveston
1999-2021
Wellcome/MRC Institute of Metabolic Science
2016
Addenbrooke's Hospital
2016
Abstract Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, process dependent upon c‐Jun transcription factor activation. Unfortunately, regeneration is greatly impaired in aged organisms following chronic denervation, which can lead to poor clinical outcomes. While diminished expression SCs has been associated with regenerative failure, it unclear whether the inability maintain repair state...
Malaria and dengue have overlapping clinical symptoms are prevalent in the same geographic region (tropical subtropical), hence precise diagnosis is challenging. The high mortality rate associated with both malaria could be attributed to "false", "delayed", or "missed" diagnosis. present study thus aims stratify using Raman spectroscopy (RS). In total, 130 human sera were analyzed for model development double-blinded testing. Principal components linear discriminant analysis (PC-LDA) of...
Abstract In Plasmodium vivax malaria, mechanisms that trigger transition from uncomplicated to fatal severe infections are obscure. this multi-disciplinary study we have performed a comprehensive analysis of clinicopathological parameters and serum proteome profiles malaria patients with different severity levels infection investigate pathogenesis identify surrogate markers severity. Clinicopathological proteomics profiling has provided evidences for the modulation diverse physiological...
Dysregulation of cell signaling in chondrocytes and bone cells, such as osteocytes, osteoblasts, osteoclasts, an elevated burden senescent cells cartilage bone, are implicated osteoarthritis (OA). Mass spectrometric analyses provides a crucial molecular tool-kit to understand complex relationships age-related diseases, OA. Here we introduce novel mass workflow promote proteomic studies bone. This uses highly specialized steps, including extensive overnight demineralization, pulverization,...
Abstract Senescence emerged as a significant mechanism of aging and age-related diseases, offering an attractive target for clinical interventions. Senescent cells release senescence-associated secretory phenotype (SASP), including exosomes that may act signal transducers between distal tissues, propagating secondary or bystander senescence signaling throughout the body. However, composition exosome SASP remains underexplored, presenting opportunity novel unbiased discovery. Here, we present...
<h3>BACKGROUND AND PURPOSE:</h3> Juvenile angiofibromas are hypervascular tumors that may benefit from preoperative devascularization to reduce intraoperative blood loss. Our purpose was evaluate the extent of angiographic and loss by using only Onyx for percutaneous juvenile angiofibroma tumor embolization. <h3>MATERIALS METHODS:</h3> We reviewed clinical records postoperative imaging studies a consecutive series 9 patients with who were treated embolization direct injection followed...
The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated serum proteome alterations in non-severe patients before and during patient recuperation starting from early febrile to defervescence convalescent stages infection. We also performed an extensive quantitative proteomics analysis compare profiles with low (LPVM) moderately-high (MPVM) parasitemia healthy community controls....
Oleaginous microalga Chlorella is a promising microbial cell factory for producing lipids, transesterifiable to biodiesel, and phytochemical, high-value molecules (HVMs). To better understand the stress-induced oleaginous mechanism of sp. FC2 IITG that closely matches with sorokiniana based on 18s rRNA gene sequence, we performed 'Algomics' by systematically integrating metabolomics proteomics data in response time-resolved nitrogen-limitation: 40 h (mild), 88 (moderate), 120 (severe). Ten...
Cellular senescence is a stress or damage response by which cell adopts of state essentially permanent proliferative arrest, coupled to the secretion number biologically active molecules. This senescence-associated secretory phenotype (SASP) underlies many degenerative and regenerative aspects cellular - including promoting wound healing development, but also driving diabetes multiple age-associated diseases. We find that nicotinamide phosphoribosyltransferase (NAMPT), catalyzes...
Dengue fever (DF) is a major global health burden with pathophysiology that still incompletely understood. Biomarkers predict and explain susceptibility to DF its progression more severe hemorrhagic form are much needed. endemic in tropical subtropical regions of the world, rapidly increasing incidence disease severity. We conducted clinical biomarker discovery study using both case–control longitudinal design. Plasma proteome alterations patients (n = 12) dengue (DHF, n 24) were analyzed...
Aging is a process often associated with various age-related diseases.Senescence one of the hallmarks aging, and senescent cells acquire complex, pro-inflammatory, secretory phenotype termed senescence-associated (SASP).Here, we show that ocular surface from human cornea become upon X-irradiation, characterized by increased β-galactosidase activity, decreased cell proliferation, expression p16, disruption epithelial barrier.Comprehensive transcriptomic proteomic analysis revealed (SOCs) an...
The objective of this study was to investigate the senescent phenotypes human corneal endothelial cells (hCEnCs) upon treatment with ultraviolet (UV)-A.
Scope Haptoglobin (Hp), an acute phase inflammatory protein is associated with malaria pathogenesis in several proteomics and genomics studies. The Hp gene has two co‐dominant alleles: Hp1 Hp2 that produce three genotypes: Hp1/Hp1, Hp1/Hp2 Hp2/Hp2. Experimental design In this study, validation of the data Multiple Reaction Monitoring Mass Spectroscopy (MRM‐MS) performed association variants severe, non‐severe community (healthy) controls using genotyping PCRs DNA sequencing analysed. Results...
Abstract Dysregulation of cell signaling in chondrocytes and bone cells, such as osteocytes, osteoblasts, osteoclasts, an elevated burden senescent cells cartilage bone, are implicated osteoarthritis (OA). Mass spectrometric analyses provides a crucial molecular tool-kit to understand complex relationships age-related diseases, OA. Here we introduce novel mass workflow promote proteomic studies cartilage. This uses highly specialized steps, including extensive overnight demineralization,...
Introduction Carotid cavernous fistulas (CCFs) are pathological shunts between the carotid artery and sinus. They a devastating cause of visual loss, periocular disfigurement orbital symptoms. Endovascular treatment has become mainstay for CCFs, with prompt intervention preventing complications further symptom progression. Methods A review our CCF database was conducted, identifying five relevant cases. We highlight variety direct or indirect CCFs treated various materials embolization...
Abstract Aging is a complex biological process associated with progressive loss of physiological function and susceptibility to several diseases, such as cancer neurodegeneration. Exosomes are involved in many cellular signaling pathways, their cargo may serve promising disease or aging biomarkers. These membrane-bound extracellular vesicles facilitate the transport intracellular contents proximal distal cells body. Here, we investigated two omics approaches for exosome analysis. To overcome...