Xiaolei Zheng

ORCID: 0000-0002-0661-6098
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About
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Research Areas
  • Hydraulic Fracturing and Reservoir Analysis
  • Enhanced Oil Recovery Techniques
  • Vaccine Coverage and Hesitancy
  • Neuroinflammation and Neurodegeneration Mechanisms
  • MicroRNA in disease regulation
  • COVID-19 and Mental Health
  • Hydrocarbon exploration and reservoir analysis
  • Alzheimer's disease research and treatments
  • Photochemistry and Electron Transfer Studies
  • Drilling and Well Engineering
  • Advanced Chemical Physics Studies
  • Spectroscopy and Quantum Chemical Studies
  • Mesenchymal stem cell research
  • Family Support in Illness
  • Misinformation and Its Impacts
  • Hippo pathway signaling and YAP/TAZ
  • Cholinesterase and Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Photochromic and Fluorescence Chemistry
  • CO2 Sequestration and Geologic Interactions
  • SARS-CoV-2 and COVID-19 Research
  • Childhood Cancer Survivors' Quality of Life
  • Acute Lymphoblastic Leukemia research
  • Intergenerational Family Dynamics and Caregiving
  • Electricity Theft Detection Techniques

Second Hospital of Shandong University
2014-2025

Xi'an Shiyou University
2024-2025

Inner Mongolia Electric Power (China)
2025

Weatherford College
2023

Peking University
2014-2022

Zhejiang Chinese Medical University
2022

Peking University People's Hospital
2022

Capital Medical University
2020-2021

Beijing YouAn Hospital
2020

Northwest University
2015-2016

In order to determine the influence of different factors on CO2 huff-and-puff displacement effect, a experiment was carried out with Chang 6 tight sandstone samples in Ordos Basin as research object. Combined nuclear magnetic resonance technology, influences injection pressure, cycle numbers and soaking time effect were evaluated, optimal parameters optimized. The microscopic degree crude oil production scale pores quantitatively characterized. results show that pressure have significant...

10.1038/s41598-025-87846-3 article EN cc-by-nc-nd Scientific Reports 2025-01-28

Introduction: With the approval of COVID-19 vaccinations for children and adolescents in China, parental vaccine hesitancy will emerge as a new challenge with regard to administration these vaccines. However, little is known regarding this well regional differences that may exist between parents from Shandong vs. Zhejiang. Methods: To assess issues, an online survey was conducted via Wenjuanxing platform over period July 22 August 14, 2021. Parents Zhejiang were recruited Wechat groups...

10.3389/fpubh.2021.779720 article EN cc-by Frontiers in Public Health 2021-11-05

Alzheimer's disease (AD) is a chronic neurological characterized by memory loss and progressive cognitive impairment. The characteristic AD pathologies include extracellular senile plaques formed β‑amyloid protein deposition, neurofibrillary tangles hyper‑phosphorylation of τ neuronal caused glial cell proliferation. However, the pathogenesis still unclear. Dysregulation RNA methylation associated with biological processes, including neurodevelopment neurodegenerative disease....

10.3892/mmr.2023.12942 article EN cc-by-nc-nd Molecular Medicine Reports 2023-01-18

Hepatitis B (Hep B) remains a critical public health issue globally, particularly in Tibet, where vaccination rates and influencing factors among college students are yet understudied. This study applies cross-sectional design to investigate the Hep rate 1,126 Tibet utilizes expanded theory of planned behavior (ETPB) identify intention (BI) (VB). Stratified cluster sampling across three universities was used assess behavioral attitudes (BA), subjective norms (SN), perceived control (PBC),...

10.1080/21645515.2025.2452026 article EN cc-by-nc Human Vaccines & Immunotherapeutics 2025-01-16

The Omicron subvariants of SARS-CoV-2 spread rapidly since 2021. Following China's relaxation containment measures in December 2022, a surge COVID-19 cases poses public health threat. Early identification elderly patients at death risk is crucial for optimizing treatment and resource use. To develop clinical score predicting hospital admission, based on cohort from the Second Hospital Shandong University. We established retrospective hospitalized November 1, to March 31, 2023. Cox regression...

10.2147/ijgm.s510647 article EN cc-by-nc International Journal of General Medicine 2025-04-01

Abstract In the context of increasing spread electric vehicle (EV) charging stations, accuracy and reliability energy measurement is becoming increasingly important for consumers. Degradation in performance smart meters at these stations often due to factors such as aging malfunctions. Traditional approaches solving this problem usually involve manual on-site inspections, which require significant investment manpower materials. To overcome challenge, study proposes an error estimation method...

10.2478/msr-2025-0006 article EN cc-by-nc-nd Measurement Science Review 2025-02-01

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. As the most common form of dementia, it affects more than 35 million people worldwide and increasing. Excessive extracellular deposition amyloid-β peptide (Aβ) pathologic feature AD. Accumulating evidence indicates that macroautophagy involved in pathogenesis AD, but its exact role still unclear. Although major findings on molecular mechanisms have been reported, there are no effective treatments to prevent, halt,...

10.1371/journal.pone.0111536 article EN cc-by PLoS ONE 2014-10-31

The coronavirus disease 2019 (COVID-19) pandemic has resulted in a plethora of psychological problems worldwide since its onset December 2019. In the upheaval period, compared with medical college students, nonmedical students' state deserves additional concern due to their lack knowledge. Although epidemic China been largely controlled for several months, mental health resulting from COVID-19 persist this day. study, we assessed and associated risk factors experienced by vs. students...

10.3389/fpsyt.2021.680202 article EN cc-by Frontiers in Psychiatry 2021-06-11

In order to improve the effect of injection–production coupling development crude oil recovery in complex fault-block reservoirs, we carried out a physical simulation experiment based on sandpack model transforming water-driven into and quantitatively evaluated influence rounds injection pressure mobilization reservoirs with different permeability levels recovery. Meanwhile, characteristics residual were studied via numerical method. The mechanism increased production was revealed by...

10.3390/en17061505 article EN cc-by Energies 2024-03-21

Objective People with visual impairment have more functional limitations associated subjective cognitive decline (SCD), and those SCD are extremely susceptible to transitioning irreversible impairment. This study aimed explore if is a significant predictor of compared other socioeconomic health factors SCD. Design Cross-sectional study. Setting participants The investigation assess the influencing among 428 aged 60 above in Zhaoyuan, China. Primary outcome measures primary variable was SCD,...

10.1136/bmjopen-2023-072626 article EN cc-by-nc BMJ Open 2024-04-01

Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)–Hippo pathway pivotal in regulating cell apoptosis, immune response, mitochondrial function, oxidative stress. However, the association between MST1 function AD remains unknown. Therefore, this study investigates effect of on damage impairment homeostasis AD. In study, 4- 7-month-old 5xFAD mice were selected to...

10.1186/s12967-024-05852-x article EN cc-by-nc-nd Journal of Translational Medicine 2024-11-22

Background With promotion of COVID-19 vaccinations, there has been a corresponding vaccine hesitancy, which older adolescents and young adults represent groups particular concern. In this report, we investigated the prevalence reasons for as well potential risk factors, within in China. Methods To assess these issues, an online survey was administered over period from March 14 to April 15, 2021. Older (16–17 years old) (18–21 were recruited nationwide Wechat results total 2,414 respondents...

10.3389/fpubh.2022.877668 article EN cc-by Frontiers in Public Health 2022-05-12

Background: Leukemia is the most common pediatric malignancy. Many children with leukemia display behavioral and emotional problems. Promoting children's psychological development quality of life during hospitalization an important activity carried out by health professionals. Objective: The objective this study was to describe experiences feelings Chinese in hospital. Method: In-depth interviews were conducted using a descriptive qualitative research method. data analyzed content analysis....

10.1097/ncc.0b013e3181efea47 article EN Cancer Nursing 2010-10-01

Photoisomerization mechanisms including two reactive pathways, one bond twist (OBT) and bicycle pedal (BP), non-reactive single torsion (SBT) reverse (RT).

10.1039/c6cp00514d article EN Physical Chemistry Chemical Physics 2016-01-01

Aging populations, along with low fertility rates, have become a pervasive world-wide problem. To address this challenge, China issued universal 3-child policy on May 31, 2021. However, little is known regarding the intentions of childbearing-aged Chinese for third child. The purpose study was to assess as related third-child and identify risk factors refusal. In cross-sectional study, total 2129 participants were recruited nationwide from June 15 July 22, Each participant interviewed using...

10.1097/md.0000000000033255 article EN cc-by-nc Medicine 2023-03-24

Amyloid β-protein (Aβ) is believed to contribute the development of Alzheimer's disease (AD). Here we showed that Aβ25-35 rapidly caused activation autophagy, subsequently leading reduction autophagy associated with cellular apoptosis. Further investigation revealed accumulation β-arrestin 1 (ARRB1) by contributed induction autophagic flux. The depletion ARRB1 led decreases in expression LC3B, Atg7, and Beclin-1, which are essential for initiation autophagy. also reduced downstream ERK...

10.1038/s41598-017-01798-x article EN cc-by Scientific Reports 2017-06-07

Emerging evidence suggests that inflammation induced by the inflammasome plays a crucial role in course of Parkinson's disease (PD). Ulinastatin (UTI) has shown significant anti-inflammatory effects. However, few studies have examined whether UTI protects neurons through its effects PD. The purpose this study is to determine exerts neuroprotection PD cell model and explore mechanisms.SH-SY5Y cells nerve growth factor (NGF)-treated PC12 were used establish MPP+ models. Cells pre-treated with...

10.21037/atm-21-1882 article EN Annals of Translational Medicine 2021-06-01

On-the-fly trajectory surface hopping dynamics simulations on the <italic>cis</italic> ↔ <italic>trans</italic> photoisomerization mechanisms of bridged-azobenzene upon S<sub>1</sub> excitation at CASSCF level.

10.1039/c6ra03788g article EN RSC Advances 2016-01-01

COVID-19, a continuously emerging human-to-human infectious disease, has exerted significant impact on the mental health of college students. However, little is known regarding variations in issues experienced by students during peak versus reopening stages COVID-19 epidemic China.To assess these issues, an online longitudinal survey was conducted via WeChat applet. Undergraduates (n = 300) were recruited from 26 universities throughout Jinan February 2020 (T1 - stage) and January 2021 (T2...

10.1159/000519586 article EN cc-by-nc Biomedicine Hub 2021-10-12

Atherosclerosis (AS) is a chronic inflammatory disease of the arterial intima. As AS represents most common type vascular disease, it affects millions individuals and source high morbidity mortality rates worldwide. Overwhelming evidence indicates that AS-related inflammation mediated by proinflammatory cytokines, chemokines, adhesion molecules signaling pathways, with each these factors being shown to play critical roles during entire progression AS. While number drugs have been approved...

10.1155/2022/5799308 article EN cc-by BioMed Research International 2022-01-21

Effective communication between nurse and patient is paramount in establishing the relationship on which care based influences quality of nursing leading to improved health outcomes for patients. It necessary nurses understand children's perspectives nurse–patient order choose appropriate skills promote effective a sweet relationship. To explore status children who were early stages living with leukemia their communication. In-depth interviews conducted Chinese using descriptive qualitative...

10.1016/j.ijnss.2014.02.003 article EN cc-by-nc-nd International Journal of Nursing Sciences 2014-03-01
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