A5101456121- Treatment of Major Depression
- Insect-Plant Interactions and Control
- Pain Management and Placebo Effect
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genomics and Phylogenetic Studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Insect Resistance and Genetics
- Agricultural pest management studies
- Organ Transplantation Techniques and Outcomes
- Insect Pest Control Strategies
- Electroconvulsive Therapy Studies
- Tryptophan and brain disorders
- Plant and animal studies
- Health Systems, Economic Evaluations, Quality of Life
- Lepidoptera: Biology and Taxonomy
- Insect and Pesticide Research
- Pancreatitis Pathology and Treatment
- Plant Virus Research Studies
- Genetic diversity and population structure
- Plant Diversity and Evolution
- Medicinal Plants and Neuroprotection
- Pancreatic and Hepatic Oncology Research
- Functional Brain Connectivity Studies
- Hymenoptera taxonomy and phylogeny
University of Sargodha
2013-2024
Jamia Hamdard
2024
King George's Medical University
2024
King Abdulaziz Medical City
2021-2023
Nord University
2019-2022
Northwest Clinical Research Center
2010-2021
Pacific Northwest University of Health Sciences
2021
Brown University
2021
Institute of Liver and Biliary Sciences
2021
Fortis Hospital
2021
Some studies suggest that more severely ill patients with depression respond well to antidepressants and poorly placebo, whereas those who are mildly equally placebo. This notion has implications for the design of clinical trials. To further assess substantiate these putative predictors antidepressant placebo response, we assessed Food Drug Administration database 45 phase II III The frequency statistically significant differences between was higher in trials included severe depression. In...
Article Abstract Objective: To assess the efficacy and safety of aripiprazole versus placebo as adjunctive treatment to standard antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who showed an incomplete response 1 prospective 3 historical courses ADT within current episode. Method: The study comprised a 7- 28-day screening phase, 8-week 6-week double-blind phase. Patients DSM-IV-TR-defined MDD were enrolled between June 16, 2004, April 27, 2006. During treatment,...
The delayed healing of wounds among people with diabetes is a severe problem worldwide. Hyperglycemia and increased levels free radicals are the major inhibiting factors wound in diabetic patients. Plant extracts rich source polyphenols, allowing them to be an effective agent for healing. Drying temperature extraction solvent highly affect stability polyphenols plant materials. However, there need optimize protocol ensure efficacy final product. For this purpose, effects drying solvents on...
Although the early antidepressant trials which included severely ill and hospitalized patients showed substantial drug‐placebo differences, these robust differences have not held up in of past couple decades, whether sponsored by pharmaceutical companies or non‐profit agencies. This narrowing difference has been attributed to a number changes conduct clinical trials. First, advent DSM‐III broadening definition major depression led inclusion mildly moderately into These may experience smaller...
Background Although they are important disease vectors mosquito biodiversity in Pakistan is poorly known. Recent epidemics of dengue fever have revealed the need for more detailed understanding diversity and distributions species this region. DNA barcoding improves accuracy inventories because morphological differences between many subtle, leading to misidentifications. Methodology/Principal Findings Sequence variation barcode region mitochondrial COI gene was used identify species, reveal...
Article Abstract Objective: To evaluate the efficacy, and further establish safety profile, of oral once-daily vilazodone, a potent selective serotonin 1A receptor partial agonist reuptake inhibitor, in treatment major depressive disorder (MDD). Method: This phase 3, randomized, double-blind, placebo-controlled, 8-week study (conducted March 2008-February 2009) enrolled 481 adults with DSM-IV-TR-defined MDD. Patients received vilazodone (titrated to 40 mg/d) or placebo. The primary efficacy...
The objective of this study was to investigate the efficacy and safety adjunctive lanicemine (NMDA channel blocker) in treatment major depressive disorder (MDD) over 12 weeks. This phase IIb, randomized, parallel-arm, double-blind, placebo-controlled conducted at 49 centers four countries between December 2011 August 2013 302 patients aged 18–70 years, meeting criteria for single episode or recurrent MDD with a history inadequate response. Patients were required be taking an allowed...
Emergence of multidrug resistant pathogens is increasing globally at an alarming rate with a need to discover novel and effective methods cope infections due these pathogens. Green nanoparticles have gained attention be used as efficient therapeutic agents because their safety reliability. In the present study, we prepared zinc oxide (ZnO NPs) from aqueous leaf extract Acacia arabica . The produced were characterized through UV-Visible spectroscopy, scanning electron microscopy, X-ray...
Background Although whiteflies (Bemisia tabaci complex) are an important pest of cotton in Pakistan, its taxonomic diversity is poorly understood. As DNA barcoding effective tool for resolving species complexes and analyzing distributions, we used this approach to analyze genetic the B. complex map distribution lineages growing areas Pakistan. Methods/Principal Findings Sequence barcode region (mtCOI-5′) was examined 593 from Pakistan determine number whitefly their distributions...
Vilazodone is a selective serotonin reuptake inhibitor and 5-HT1A partial agonist approved for major depressive disorder (MDD) treatment in adults. This was 10-week, multicenter, double-blind, placebo-controlled active-controlled, fixed-dose trial (NCT01473381). Adult patients with MDD (Diagnostic Statistical Manual of Mental Disorders, 4th ed., text revision criteria) were randomized 1 : to vilazodone 20 or 40 mg/day, citalopram placebo. Primary efficacy: Montgomery-Åsberg Depression Rating...
<h3>Background:</h3> Major depressive disorder (MDD) is a global health concern. This study examined the efficacy, safety and tolerability of an extended-release (ER) formulation levomilnacipran, antidepressant approved for treatment MDD in adults. <h3>Methods:</h3> 10-week (1-week placebo run-in period, 8-week double-blind treatment, 1-week down-taper), multicentre, double-blind, placebo-controlled, parallel-group, fixed-dose was conducted between June 2011 March 2012. Adult outpatients...
Tuberculosis (TB) is an important public health issue around the globe which a chronic infectious disease and still one of major challenges for developing countries. The emergence drug-resistant TB makes condition worse there urgent need fast, highly sensitive diagnostic methods. This study was undertaken to evaluate performance GeneXpert® MTB/RIF assay MTB culture detection Mycobacterium tuberculosis (MTB) in sputum smear-negative pulmonary TB/drug-resistant (DR-TB) suspects. A total 168...
Commiphora gileadensis and C. foliacea (family Burseraceae) are pantropical in nature known for producing fragrant resin (myrrh). Both the tree species economically medicinally important however, least genomic understanding is available this genus. Herein, we report complete chloroplast genome sequences of comparative analysis with related (C. wightii Boswellia sacra). A modified DNA extraction method was adopted, followed next generation sequencing, detailed bioinformatics PCR analyses. The...
The authors examined which, if any, research design features and patient characteristics would significantly differ between successful unsuccessful antidepressant trials.Clinical trial data were reviewed for nine antidepressants approved by the Food Drug Administration 1985 2000. From programs on these medications, 52 clinical trials included in study. evaluated features, characteristics, difference response placebo antidepressant.Nine present all of antidepressants. severity depressive...
This multicenter, double-blind, placebo-controlled study using a randomized withdrawal design evaluated the efficacy and safety of once-daily OROS hydromorphone ER in treatment opioid-tolerant patients with chronic moderate-to-severe low back pain (LBP).The primary assessment was mean change intensity based on patient diary Numeric Rating Scale (NRS) scores from baseline to final visit 12-week double-blind phase. Secondary endpoints included each NRS scores; office time failure; Patient...
Article AbstractBackground: The development of new antidepressant drugs has reached a plateau. There is an unmet need for faster, better, and safer medications, but as placebo-response rates rise, effect sizes shrink, more studies fail or are negative, pharmaceutical companies increasingly reluctant to invest in drug because the risk failure. In absence identifiable human pathophysiology that can be modeled preclinical studies, principal point leverage move beyond present dilemma may...
The increasing rate of failure antidepressant clinical trials has led to the assertion that antidepressants do not have meaningful benefits. Our hypothesis was decrease in antidepressant–placebo differences over past three decades could be explained by changes research design features rather than a lack potency being tested. We collected data from 130 double blind placebo controlled conducted between 1981 and 2008 included 35,122 depressed patients with 23,157 assigned 11,965 placebo....
Plantago ovata (Plantaginaceae) is an economically and medicinally important species, however, least known about its genomics evolution. Here, we report the first complete plastome genome of P. comparison with previously published genomes related species from Plantaginaceae. The results revealed that size was 162,116 bp it had typical quadripartite structure containing a large single copy region 82,084 small 5,272 bp. has markedly higher inverted repeat (IR) 37.4 kb, suggesting large-scale...
Background: Hypertension is one of the most common medical disorders associated with pregnancy. It second leading cause maternal mortality during pregnancy and affects in every ten cases. Maternal fetal complications hypertension can be highly destructive lead for example stroke, seizures, placental abruption, death, death etc. In current study, we tend to provide a comprehensive but short review literature relevant induced hypertension. Importantly, its prevalence distribution Pakistan...