A5035361188- RNA modifications and cancer
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Circadian rhythm and melatonin
- Non-Invasive Vital Sign Monitoring
- Biomedical and Engineering Education
- Mobile Health and mHealth Applications
- GDF15 and Related Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Heart Rate Variability and Autonomic Control
- Estrogen and related hormone effects
- Genetics, Aging, and Longevity in Model Organisms
- Light effects on plants
- Immune Cell Function and Interaction
- Cardiac pacing and defibrillation studies
- Primary Care and Health Outcomes
- Statistical Methods in Clinical Trials
- ECG Monitoring and Analysis
- Blood Pressure and Hypertension Studies
- Digestive system and related health
- Cardiac Fibrosis and Remodeling
- Influenza Virus Research Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular and exercise physiology
- Gene Regulatory Network Analysis
Baylor College of Medicine
2014-2024
Children's Cancer Center
2017-2023
Texas Medical Center
2019
Rice University
2017-2018
University of Houston
2007-2015
Institute for the Future
2010-2015
Institut de Biologie Moléculaire et Cellulaire
2014
National Institute of Biomedical Imaging and Bioengineering
2014
Baylor University
2012
Houston Methodist
1976-2011
Background: Men diagnosed with localized prostate cancer face a potentially life-altering treatment decision that can be overwhelming. Enhancing patient knowledge through education significantly reduce feelings of uncertainty while simultaneously increasing confidence in making. Serious games have been shown other populations to increase health and assist the decision-making process. We developed an interactive serious game, Time After Time, which translates evidence-based outcome data into...
This paper summarizes the panel discussion at IEEE Engineering in Medicine and Biology Point-of-Care Healthcare Technology Conference (POCHT 2013) held Bangalore India from Jan 16-18, 2013. Modern medicine has witnessed interdisciplinary technology innovations healthcare with a continuous growth life expectancy across globe. However, there is also growing global concern on affordability of rapidly rising costs. To provide quality reasonable costs, to be convergence preventive, personalized,...
Our group recently characterized a cell-autonomous mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regulation remain poorly understood. Here, we show that in mouse liver, transcriptional significantly contributes to establishment rhythms mRNA expression manner dependent on Spliced Form X-box Binding Protein 1 (XBP1s). Mechanistically, motif stringency XBP1s promoter binding sites dictates XBP1s's ability drive nascent transcription at dawn dusk,...
Two infections by swine influenza virus, antigenically similar to A/New Jersey/76 (H1N1) were detected during community epidemics with other viruses. The swinelike viruses obtained virological surveillance of acute respiratory illnesses, and the clinical symptoms these two patients those caused Both reported contact a few days before onset illness, but in one case it was brief. Serological studies suggested that patient may have transmitted virus his roommate, spread into not indicated.
Most decisions in life involve ambiguity, where probabilities can not be meaningfully specified, as much they probabilistic uncertainty. In such conditions, the aspiration to utility maximization may self‐deceptive. We propose “robust satisficing” an alternative maximizing normative standard for rational decision making circumstances. Instead of seeking maximize expected value, or utility, a outcome, robust satisficing aims robustness uncertainty satisfactory outcome. That is, asks, “what is...
A distinct 12-hour clock exists in addition to the 24-hour circadian coordinate metabolic and stress rhythms. Here, we show that liver-specific ablation of X-box binding protein 1 (XBP1) disrupts hepatic promotes spontaneous non-alcoholic fatty liver disease (NAFLD). We XBP1 predominantly regulates rhythmicity gene transcription mouse demonstrate perturbation clock, but not core is associated with onset progression this NAFLD phenotype. Mechanistically, provide evidence spliced form (XBP1s)...
Steroid receptor coactivator 3 (SRC-3) is most strongly expressed in regulatory T cells (Tregs) and B cells, suggesting that it plays an important role the regulation of Treg function. Using aggressive E0771 mouse breast cell line syngeneic immune-intact murine model, we observed tumors were “permanently eradicated” a genetically engineered tamoxifen-inducible Treg-cell-specific SRC-3 knockout (KO) female does not possess systemic autoimmune pathological phenotype. A similar eradication...
The 12-h clock coordinates lipid homeostasis, energy metabolism, and stress rhythms via the transcriptional regulator XBP1. However, biochemical physiological bases for integrated control of diverse metabolic pathways remain unclear. Here, we show that steroid receptor coactivator SRC-3 coactivates XBP1 transcription regulates hepatic cistrome gene rhythmicity. Mice lacking abnormal in transcription, functions, systemic energetics, rate-limiting processes, including triglyceride,...
GIM/FP/GP: [Formula: see text] Infectious Disease: Pulmonology: Public Health: text].
Congestive Heart Failure (CHF) is a serious cardiac condition that brings high risks of urgent hospitalization and death. Remote monitoring systems are well-suited to managing patients suffering from CHF, can reduce deaths re-hospitalizations, as shown by the literature, including multiple systematic reviews. The system proposed in this paper aims at helping CHF stakeholders make appropriate decisions disease preventing events, such decompensation, which lead or Monitoring activities...
Significance We are at an exciting era of identification the cell and molecular processes necessary for tissue remodeling repair. Unlike current systemic therapeutics, our studies reveal pharmacologic stimulation SRCs modulates macrophage fibrotic reparative responses to promote more effective repair lasting beneficial after myocardial infarction.
Background:Technology use for symptom management is beneficial both patients and physicians. Widespread acceptance of technology in healthcare fuels continued development with ever-increasing sophistication. Although by medical professionals evident, less known about the perceptions, preferences, heart failure (HF) patients. This study explores patients' perceptions current managing HF symptoms (MHFS).Materials Methods:A qualitative analysis in-depth individual interviews using a constant...
Circadian rhythmicity, the 24-hour cycle responsive to light and dark, is determined by periodic oscillations in gene transcription. This phenomenon has broad ramifications physiologic function. Recent work disclosed more cycles transcription, uncovering of these we apply a novel signal processing methodology known as pencil method compare it conventional parametric, nonparametric, statistical methods. Methods: In order assess periodicity expression over time, analyzed database derived from...
We recently discovered that steroid receptor coactivators (SRCs) SRCs-1, 2 and 3, are abundantly expressed in cardiac fibroblasts (CFs) their activation with the SRC small molecule stimulator MCB-613 improves function dramatically lowers pro-fibrotic signaling CFs post-myocardial infarction. These findings suggest CF-derived could be beneficial mitigation of chronic heart failure after ischemic insult. However, cardioprotective mechanisms by which contribute to pathological remodeling...
The prophylactic effect of low doses human leukocyte interferon (HuIFN-α) against infection with rhinovirus was measured in double-blind, placebo-controlled studies volunteer subjects. An antihistamine (chlorpheniramine) given before administration single or multiple HuIFN-α by saturated cotton pledget aerosol; volunteers were then challenged rhinovirus. When the results for all groups combined, a lower frequency respiratory illness demonstrated HuIFN-α–treated (20 39 vs. 11 38, P < 0.05). A...
Background: Asthma is the most common chronic disease in childhood, disproportionately affecting urban, minority, and disadvantaged children. Individualized care plans supported by daily lung-function monitoring can reduce morbidity mortality. However, despite 20 years of interventions to increase adherence, only 50% US youth accurately follow their plans, which leads millions preventable hospitalizations, emergency room visits, sick days every year. We present a feasibility study novel,...