Abstract In recent years, immune checkpoint inhibitor has achieved remarkable success in multiple cancer treatment. However, how to pre‐judge which patients are suitable for is a difficult problem. We use the existing public bioinformatics database comprehensively analyze relationship between clinical data of various cancers with blocking molecules and long non‐coding RNAs (lncRNAs), try find potential predictive value lncRNA immunotherapy inhibitors. this study, we found that: (a) high...

2,5-dimethylcelecoxib (DMC), a derivative of celecoxib, is an inhibitor microsomal prostaglandin E synthase-1 (mPGES-1). Our previous studies have demonstrated that DMC inhibits the expression programmed death-ligand 1 on hepatocellular carcinoma (HCC) cells to prevent tumor progression. However, effect and mechanism HCC infiltrating immune remain unclear. In this study, single-cell-based high-dimensional mass cytometry was performed microenvironment mice treated with DMC, celecoxib MK-886...

Abstract: Prostaglandin E2 (PGE2) plays a crucial role in inflammation. Non-steroidal anti-inflammatory medications are commonly utilized to alleviate pain and address inflammation by blocking the production of PGE2 cyclooxygenase (COX). However, selective inhibition COX can easily lead series risks for cardiovascular diseases. Hence, it is imperative discover safer more efficient targets reducing Research has demonstrated that mPGES-1 serves as final enzyme controls rate prostaglandin...

This paper focuses on the modeling challenges of a multi-cell heterojunction bipolar transistor (HBT) used in radio frequency (RF) power amplifiers and proposes an innovative linear small-signal method. Based devices with emitter size 3 μm × 40 2–6 (emitter width length index-cell number), equivalent circuit model including peripheral parasitic parameters is constructed by analyzing device layout characteristics response to additional effects introduced structure. A step-by-step parameter...

Background 2,5-dimethylcelecoxib (DMC) is a targeted inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), key enzyme in the PGE2 synthesis pathway inflammatory mediators. Previous studies have confirmed that DMC can inhibit growth hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). However, it not known whether involved changes tumor immune microenvironment. Methods In this study, we explored effects on HBV-related HCC microenvironment, and deeply analyzed its unique...

Abstract Carbamoyl phosphate synthase 1 (CPS1) is the rate‐limiting enzyme in first step of urea cycle and an indispensable metabolism human liver. However, CPS epigenetic regulation involves promoter analysis role liver‐enriched transcription factors ( LETF s), which not fully elucidated. In this work, region hCPS gene was cloned, its activity investigated. An , hepatocyte nuclear factor 3‐beta HNF 3β), found to promote transcriptional expression liver‐derived cell lines. addition,...

The infection rate of human papillomavirus (HPV) is high in the coastal regions China. However, among high-risk genotypes women Putian City unknown. Therefore, this study aimed to analyse epidemiology HPV and provide a reference for diagnosis, treatment vaccination cervical cancer region.The data used were obtained from Chinese government's public health program ("Cervical Breast Cancer Screening Project"). A total 40,693 female cell exfoliation samples screened at Affiliated Hospital...

Abstract Background This study aims to explore the infection and age distribution of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) Herpes simplex virus type II (HSV II) among outpatients Reproductive Medicine Center in Putian, Fujian Province provide a clinical basis for early diagnosis treatment various reproductive tract diseases infertility this region. Methods A total 1736 samples secretions exfoliated cervical cells were collected from Affiliated...

Abstract Oxidative stress caused by pregnancy‐induced hypertension syndrome significantly affects the health of pregnant women. Hydrogen sulfide is a typical gaseous signal molecule against oxidative stress, and it profound significance to develop detection method. In this study, stimuli‐responsive hydrogel was constructed based on coordination bonding principle metal ions chitosan (CS) realize quantitative hydrogen (H 2 S). The chain CS contains large number amino groups hydroxyl groups,...

Abstract: The polyamidoamine (PAMAM) dendrimer, a type of macromolecule material, has been used in spheroidal cell culture and drug delivery recent years. However, PAMAM is not involved the study hepatic cell-spheroid or its biological activity, particularly detoxification function. Here, we constructed PAMAM-dendrimer conjugate decorated by an integrin ligand: arginine–glycine–aspartic acid (RGD) peptide. Our studies demonstrate that RGD–polyethylene glycol (PEG)–PAMAM conjugates can...

According to the thermal theory, self-heating effect is equivalent an R-C circuit. Based on a small-signal circuit analysis, analytical method extract resistance and capacitance for RF silicon-on-insulator (SOI) MOSFETs proposed in this paper. The geometry dependence of investigated by using method. verified partial depletion-SOI process. results show that decreases increases as effective channel area increases. A simple equation estimate characteristics help optimize device structure design...

The gate leakage current of p-GaN HEMTs is modeled based on surface potential calculations. model accurately describes the bias and temperature dependence leakage. Thermionic emission main mechanism in forward operation while hopping transport component reverse operation. This newly developed was implemented Verilog-A. A good agreement between simulations experimental data demonstrates accuracy model.

mPGES-1 is a terminal rate-limiting enzyme responsible for inflammation-induced PGE2 production. The inhibition of has been considered as safe and effective target the treatment inflammation cancer. However, specific, efficient, simple method high-throughput screening inhibitors still lacking. In this study, we developed fluorescence imaging strategy to monitor expression via CRISPR/Cas9 knock-in system. Immunofluorescence colocalisation, Sanger sequencing, RNAi, IL-1β all confirmed...

Abstract In the actual use process, characteristics of wire‐wound power inductor will change. On one hand, DC bias fluctuate because working current is not constant; on other there a variable magnetic field, which, according to principle electromagnetic, affects structural size, core permeability, and flux density, both which affect amount inductance. As result, this research examines SMD inductor's nonlinear behavior modeling approach. Under condition zero at normal temperature, static...

This study presents the extraction and verification of a small-signal model suitable for characterizing THz InP double heterojunction bipolar transistors (DHBTs). The π-type topology is adopted in intrinsic model. Capacitances Ccx Cce are used to characterize capacitive parasitics caused by routing line connecting collector terminal, base terminal emitter respectively. inductive introduced also considered. initial values parameters extracted using direct method. method verified adopting an...

In this paper we present a new BSIM4-based RF MOS varactor model. The model accurately models the behavioral for submicron when gate leakage effect needs to included. also accounts temperature parasitic resistance and capacitance are considered in Q-factor extraction.

We propose a surface potential (SP)-based compact model of p-GaN gate high electron mobility transistors (HEMTs) which solves the Poisson equation. The includes all possible charges in GaN channel layer, including unintended Mg doping density caused by out-diffusion. SP equation and its analytical approximate solution provide degree accuracy for calculation, from closed-form I–V equations are derived. proposed uses physical parameters only is implemented Verilog-A code.

Knowledge of thermal characteristic in device is valuable to management determination. In this paper, the dynamic bulk FinFET investigated with an analytic method impedance extraction. The validation confirmed model smallsignal Y-parameters at low frequency. results show that, although saturation current relatively small, associated temperature rise very significant. As comparison, behavior SOI also investigated. provide a reliable base for selection algorithms circuits carrying various...

This paper describes the application of T&M (test and measure) in device characterization which is used RF/MW field. With on-wafer measured results CV, IV S-parameter certain bias conditions, performance devices can be expressed modeled a clear form. The process according to fit for cogeneric transistor, e.g. BJT, HBT etc. A GaAs transistor has been demonstrated as an example this paper.

Abstract A new small‐signal model for carbon nanotube field effect transistor (CNFET) is proposed which incorporates the of metallic nanotubes (m‐CNTs). The m‐CNTs comprehensively modeled by contact resistance between and source/drain (S/D), also taken into account a parallel RC circuit composed C mts , mtd, non‐linear R dsm . An analytical method presented to extract parameters. validated using multi‐tube (MT) CNFET with eight gate fingers 400 nm length 50 μm width each manufactured in 700...