Fatima S. Ugur
A5085396918- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- vaccines and immunoinformatics approaches
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- Computational Drug Discovery Methods
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Advanced Proteomics Techniques and Applications
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
University of California, San Francisco
2018-2022
University of Michigan
2018
A newly described coronavirus named severe acute respiratory syndrome 2 (SARS-CoV-2), which is the causative agent of disease 2019 (COVID-19), has infected over 2.3 million people, led to death more than 160,000 individuals and caused worldwide social economic disruption1,2. There are no antiviral drugs with proven clinical efficacy for treatment COVID-19, nor there any vaccines that prevent infection SARS-CoV-2, efforts develop hampered by limited knowledge molecular details how SARS-CoV-2...
ABSTRACT Mycobacterium tuberculosis is a critical threat to human health due the increased prevalence of rifampin resistance (RMP r ). Fitness defects have been observed in RMP mutants with amino acid substitutions β subunit RNA polymerase (RNAP). In clinical isolates, this fitness defect can be ameliorated by presence secondary mutations double-psi β-barrel (DPBB) domain β′ RNAP. To identify factors contributing vivo , several vitro transcription assays were utilized probe initiation,...
ABSTRACT Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it highly tolerant to mutation during selection experiments performed in laboratory. We have proposed that this discrepancy results from difference between fitness under laboratory culture conditions and selective pressures changing environments timescales. Building on our previous work (Mavor et al., 2016), we used deep mutational scanning determine how twelve new chemicals...
The H3K4me3 chromatin modification, a hallmark of promoters actively transcribed genes, is dynamically removed by the KDM5 family histone demethylases. demethylases have number accessory domains, two which, ARID and PHD1, lie between segments catalytic domain. KDM5C, which has unique role in neural development, harbors mutations adjacent to its domains that cause X-linked intellectual disability (XLID). roles these remain unknown, limiting an understanding how XLID affect KDM5C activity....
Understanding the ligand preferences of epigenetic reader domains enables identification modification states chromatin with which these associate and can yield insight into recruitment catalysis chromatin-acting complexes. However, thorough exploration is hindered by limitations traditional protein–ligand binding assays. Here, we evaluate PHD1 domain histone demethylase KDM5A using protein interaction SAMDI (PI-SAMDI) assay, measures in a high-throughput sensitive manner via binding-induced...
Abstract Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it highly tolerant to mutation during selection experiments performed in laboratory. We have proposed that this discrepancy results from difference between fitness under laboratory culture conditions and selective pressures changing environments time scales. Building on our previous work (Mavor et al 2016), we used deep mutational scanning determine how twelve new chemicals...
ABSTRACT The H3K4me3 chromatin modification, a hallmark of promoters actively transcribed genes, is dynamically removed by the KDM5 family histone demethylases. demethylases have number accessory domains, two which, ARID and PHD1, lie between segments catalytic domain. KDM5C, which has unique role in neural development, harbors mutations adjacent to its domains that cause X-linked intellectual disability (XLID). roles these remain unknown, limiting an understanding how XLID affect KDM5C...