A5038957953- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Lipid Membrane Structure and Behavior
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Protein Structure and Dynamics
- Bacteriophages and microbial interactions
- Health and Medical Research Impacts
- Ion channel regulation and function
- Global Health and Surgery
- Biochemical Analysis and Sensing Techniques
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
- vaccines and immunoinformatics approaches
- Chemical Thermodynamics and Molecular Structure
- Advanced Proteomics Techniques and Applications
- Influenza Virus Research Studies
University of California, San Francisco
2015-2024
Institute for Neurodegenerative Disorders
2019-2020
Arizona State University
2015-2019
Universidad Católica de Santa Fe
2019
Resonance Research (United States)
2015
ABSTRACT Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it highly tolerant to mutation during selection experiments performed in laboratory. We have proposed that this discrepancy results from difference between fitness under laboratory culture conditions and selective pressures changing environments timescales. Building on our previous work (Mavor et al., 2016), we used deep mutational scanning determine how twelve new chemicals...
The M2 proton channel aids in the exit of mature influenza viral particles from host plasma membrane through its ability to stabilize regions high negative Gaussian curvature (NGC) that occur at neck budding virions. channels are homo-tetramers contain a cytoplasm-facing amphipathic helix (AH) is necessary and sufficient for NGC generation; however, constructs containing transmembrane spanning helix, which facilitates tetramerization, exhibit enhanced generation. Here, we used all-atom...
Abstract TRPM8 is a member of the transient receptor potential ion channel family where it functions as cold and pain sensor in humans other higher organisms. Previous studies show that requires signaling phosphoinositide lipid PIP 2 to function. function further regulated by diverse mechanisms, including small modulatory membrane protein PIRT ( p hospho i nositide r egulator T RP). Like TRPM8, also binds behavioral have shown required for normal TRPM8-mediated cold-sensing. To better...
Neuroactive compounds are crucial tools in drug discovery and neuroscience, but it remains difficult to discover neuroactive with new mechanisms of action. To address this need, researchers have developed mid-throughput phenotype-first approaches using zebrafish. This study introduces an open, non-commercial, extensible hardware/software platform that captures analyzes drugmodulated phenotypic responses larval We provide full specifications, computer-aided design (CAD) documents, source...
Abstract Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it highly tolerant to mutation during selection experiments performed in laboratory. We have proposed that this discrepancy results from difference between fitness under laboratory culture conditions and selective pressures changing environments time scales. Building on our previous work (Mavor et al 2016), we used deep mutational scanning determine how twelve new chemicals...
Abstract The M2 proton channel aids in the exit of mature influenza viral particles from host plasma membrane through its ability to stabilize regions high negative gaussian curvature (NGC) that occur at neck budding virions. channels are homo-tetramers contain a cytoplasm-facing amphipathic helix (AH) is necessary and sufficient for NGC generation; however, constructs containing transmembrane spanning helix, which facilitates tetramerization, exhibit enhanced generation. Here we used...