A5101818900- Glycosylation and Glycoproteins Research
- Urinary Bladder and Prostate Research
- Galectins and Cancer Biology
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Bladder and Urothelial Cancer Treatments
- Urinary Tract Infections Management
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Diverticular Disease and Complications
- Urologic and reproductive health conditions
- Ubiquitin and proteasome pathways
- Pediatric Urology and Nephrology Studies
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Proteoglycans and glycosaminoglycans research
- Signaling Pathways in Disease
- Anorectal Disease Treatments and Outcomes
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Hormonal and reproductive studies
- Cancer Research and Treatments
Peking University
2015-2025
Peking University First Hospital
2015-2025
First People's Hospital of Yuhang District
2022
Soochow University
2008-2018
First Affiliated Hospital of Soochow University
2010-2018
Beijing Administration Institute
2017
National Cancer Center
2015
Suzhou Vocational Health College
2009
First People’s Hospital of Jingmen
2008
First Hospital of China Medical University
2006
Abstract Aims In China, more and research on the management of urinary incontinence (UI) is being conducted; a robust questionnaire to evaluate symptoms impact UI will be very helpful. Thus, Chinese version The International Consultation Incontinence Questionnaire (ICIQ) was developed. Methods Initial translation back ICIQ‐UI short form, ICIQ‐FLUTS, ICIQ‐FLUTS long ICIQ‐LUTSqol, ICIQ‐FLUTSsex were completed by native English speaker, respectively. Then, psychometric properties five ICIQ...
Vesicovaginal fistula (VVF) refers to an abnormal communication between the bladder and vagina, leading uncontrolled leakage of urine from vagina. This study aimed assess efficacy safety robot-assisted laparoscopic VVF repair with a "rainbow-shaped" peritoneal flap. A retrospective analysis was conducted on 15 patients who underwent July 2021 March 2023 in Peking University First Hospital. The patient cohort included 1 had undergone abdominal total hysterectomy, 11 cervical conization, 2...
Background Vaginal preparation before transvaginal gynecological surgeries improves the success rate. However, there is no consensus on which agent superior for repair of vesicovaginal fistula (VVF). We aimed to compare irritation symptoms and antimicrobial function between sterile normal saline (SS) 1% povidone-iodine (PI) vaginal in surgical VVF.
The main challenge in treating patients with advanced fatal prostate cancer (PCa) is resistance to androgen deprivation therapy (ADT), which can gradually develop into metastatic castration-resistant (mCRPC). However, the pathologic mechanisms of mCRPC are still far from clear. Given high incidence and mortality associated mCRPC, understanding causes pathogenesis this condition as well identifying potential biomarkers great importance. In research reported here, we integrated several gene...
Bitter taste receptors (TAS2Rs) are traditionally thought to be expressed exclusively on the buds of tongue. However, accumulating evidence has indicated that this receptor family performs non-gustatory functions outside mouth in addition taste. Here, we examined role TAS2Rs human and mouse detrusor smooth muscle (DSM). We showed mRNA for various TAS2R subtypes was both (DSM) at distinct levels. Chloroquine (CLQ), an agonist TAS2Rs, concentration-dependently relaxed carbachol- KCl-induced...
Protein kinase B (AKT) and glycogen synthase kinase‐3β (GSK‐3β) are major components of insulin–AKT signaling that plays crucial roles in various types tissue. Recent studies found these two kinases modified posttranslationally by O‐GlcNAcylation. Here, we demonstrate O‐GlcNAcylation regulated phosphorylation/activation AKT GSK‐3β different manners kidney HEK‐293FT cells, but did not affect hepatic HepG2 cells. In neuronal phosphorylation negatively, had no effect on GSK‐3β. These results...
Aberrant glycosylation of cell surface glycoprotein due to specific alterations glycosyltransferase activity is usually associated with invasion and metastasis cancer, particularly gastric carcinomas. Polypeptide N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), which catalyzes initiation mucin-type O-glycosylation, also involved in tumor migration invasion. However, a comprehensive understanding how ppGalNAc-T2 correlates the metastasic potential human cancer not currently available. In...
Objectives This study assessed the effect of diet habits on lower urinary tract symptoms (LUTS) and sexual function in Chinese men with LUTS/benign prostatic hypertrophy (LUTS/BPH). Setting Multicentre conducted between July 2013 December 11 hospitals 3 geographic regions China. Participants Overall, participants LUTS/BPH accounted for 61.4% (2584/4208) respondents, whose data were processed following statistical analysis. Primary secondary outcome measures LUTS based International Prostate...
Aberrant glycosylation is known to be associated with cancer chemoresistance. β‑1,3‑N‑acetylglucosaminyltransferase (β3GnT)8, which synthesizes polylactosamine on β1‑6 branched N‑glycans, dramatically upregulated in colorectal (CRC). 5‑Fluorouracil (5‑FU) resistance remains a major obstacle the chemotherapy of CRC. However, little regard correlation between 5‑FU and expression β3GnT8 In this study, 5‑FU‑resistant cell line (SW620/5‑FU) was generated, 50% inhibition concentration (IC50)...
Changes in glycosylation due to specific alterations of glycosyltransferase activity have been shown various tumor cells, including human glioma cells. β1,3-N‑acetylglucosaminyltransferase-8 (β3GnT8) catalyzes the formation polylactosamine on β1-6 branched N-glycans. Upregulated expression β3GnT8 was described some tumors, but its precise role regulating invasion and metastasis remains unclear. In this study, we report an investigation by immunohistochemical analysis. Out 42 tissues, 37...
5‑Fluorouracil (5‑FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, which were found to have N‑glycans containing polylactosamine on cancer cell surface. Alterations in expression and structure glycans are associated with cellular differentiation oncogenesis. However, little known regard correlation between levels expressed colon cells anticancer effect 5‑FU. In present study, SW620 treated half maximal inhibitory concentration (IC50; determined by MTT‑assay)...
Polypeptide, N-acetylgalactosaminyltransferase 2 (ppGalNAc-T2), is a member of the ppGalNAcT family which initial glycosyltransferase in O-glycan synthesis. Our previous studies have demonstrated that ppGalNAc-T2 plays vital role process tumor emergence and development. In this study, we aimed to determine whether correlated with invasion metastasis human glioma cells. PpGalNAc-T2 sense vectors interference constructed our laboratory were successfully transfected into SHG44 U251 cells,...
// Yuke Chen 1,2,* , Wei Yu Fan 1,2 Liqun Zhou Yang 1 Huihui Wang 3 Yuan Jiang Xiaoying Shiliang Wu and Jie Jin Department of Urology, Peking University First Hospital, Xicheng, Beijing, China 2 Institute University, National Urological Cancer Center, Radiology, * These authors have contributed equally to this work Correspondence to: Wu, email: Jin, Keywords : prostate cancer, radical prostatectomy, extracapsular extension, nomogram, multi-parametric magnetic resonance imaging Received March...
Abstract We aim to investigate the correlation of benign prostatic obstruction (BPO)‐related complications with clinical outcomes in patients after transurethral resection prostate China. reviewed medical history all who underwent surgery from 1992 2013. assessed preoperative profile, management, and operative complications. Overall, 2271 were enrolled study. Of these patients, 1193 (52.5%) had no BPO‐related 1078 (46.3%) Compared without complications, those older ( p = 0.001) usually other...
To explore urodynamic characteristics and their clinical value in pelvic lipomatosis (PL) patients.We reviewed the information of 84 PL patients. A voiding pressure-flow study was used to classify patients into nonoutlet obstruction (NOO), latter-half-section (LHSO), or whole-section bladder outlet (BOO) groups. Urinary morphologic features were measured by imaging examination cystoscopy.A unique LHSO that presented as sudden increasing detrusor pressure (Pdet) decreasing flow rate latter...