A5057096158- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Eosinophilic Esophagitis
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Veterinary medicine and infectious diseases
- Celiac Disease Research and Management
- Galectins and Cancer Biology
- Mathematical Biology Tumor Growth
- Effects of Radiation Exposure
- Monoclonal and Polyclonal Antibodies Research
- Advanced Radiotherapy Techniques
- Pain Management and Treatment
- Viral gastroenteritis research and epidemiology
- Gastrointestinal disorders and treatments
- Radiation Therapy and Dosimetry
- Telemedicine and Telehealth Implementation
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Prostate Cancer Diagnosis and Treatment
- Evolutionary Game Theory and Cooperation
- Cancer Immunotherapy and Biomarkers
University of Alabama at Birmingham
2021-2024
Novant Health
2023
Moffitt Cancer Center
2017-2022
ORCID
2020
University of Central Florida
2016
University of Nottingham
2000
Stony Brook Medicine
2000
Japanese Red Cross Hiroshima College of Nursing
1998
Hiroshima University
1998
Riley Hospital for Children
1998
The diagnostic significance of the serological detection antibodies to Helicobacter pylori has been established by numerous investigators. Reports clinical reliabilities commercial enzyme immunoassay (EIA) kits available for this purpose vary as a result different H. antigen sources and reference methods used. 13C urea breath test (UBT) shown be an extremely accurate reliable method detecting infection. We used confirmatory status evaluate three commercially EIA designed detect...
Abstract Recurrent high grade glioma patients face a poor prognosis for which no curative treatment option currently exists. In contrast to prescribing dose hypofractionated stereotactic radiotherapy (HFSRT, $$\ge 6$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mo>≥</mml:mo> <mml:mn>6</mml:mn> </mml:mrow> </mml:math> Gy $$\times$$ <mml:mo>×</mml:mo> 5 in daily fractions) with debulking intent, we suggest personalized strategy improve tumor control by delivering...
ABSTRACT It has been suggested that enzyme immunoassay (EIA) kits validated in one region may yield variable diagnostic performance results different regions, possibly due to strain-specific differences antibody responses populations. We tested 13 C-urea breath test-characterized serum samples from 109 U.S. patients and 288 Japanese using with preparations of high-molecular-weight cell-associated (HM-CAP) antigens are conserved across Helicobacter pylori strains. Replicate were prepared five...
Abstract To investigate the functional significance of epidermal growth factor (EGF) receptor phosphorylation, experimental systems were explored in which phosphorylation on tyrosine and serine/threonine could be differentially stimulated. Exposure A431 cells to 20 nM EGF at 37°C results serine, threonine, sites receptor. Monoclonal antibody (mAb) 225 binds with affinity comparable competes binding EGF. presence 300 anti‐EGF mAb (15‐fold excess) selectively activated serine threonine...
OBJECTIVES: The purpose of this study was to determine the prevalence serum antibodies directed against Helicobacter pylori (H. pylori) in children referred children's hospitals or medical centers throughout United States. METHODS: This multisite cross-sectional prospective involved 992 from 12 states using a validated anti–H. IgG enzyme immunoassay. were recruited into two groups: those without any GI complaints (non–GI referral, n = 619) and who for endoscopy because abdominal pain (GI...
OBJECTIVE: Prior studies have suggested that IgG antibody titers may be useful to confirm successful treatment of Helicobacter pylori (H. pylori) infection. However, the diagnostic value decreasing is limited by necessity perform pre and posttreatment tests in parallel which requires stored sera. Our objective was assess accuracy using HM-CAP EIA kit (Enteric Products) monitoring H. infection compare relative versus serial determinations. METHODS: The 14C urea breath test (UBT) used 83...
Summary Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection. Methods The H. status was determined at entry (D0) by culture and histology performed on antral biopsies treatment day 42 (day 42) 6 months (M6) 13 C‐urea breath test. EIA kits used to determine anti‐ antibody titre were HM‐CAP (immunoglobulin‐G) PP‐CAP (immunoglobulin‐A) (Enteric Products, Inc.) Pyloriset EIA‐G (Orion Diagnostica). Results Ninety‐three patients included. For 82 who...
ABSTRACT The prevalence of Helicobacter pylori infection in a population-based sample 477 children (mean age ± standard deviation, 5.8 0.5 years) determined by the [ 13 C]urea breath test ([ C]UBT) was 10.7% (95% confidence interval [CI], 8.1 to 13.8%), and that salivary enzyme-linked immunosorbent assay (ELISA) 11.9% CI, 9.2 15.2%). Compared C]UBT, sensitivity specificity ELISA were 80.9% 66.3 90.4%) 95.3% 92.7 97.1%), respectively.
Abstract Background. Enzyme linked immunosorbent assay (ELISA) evaluation of oral fluid immunoglobulin G (IgG) antibodies to Helicobacter pylori is a unique approach for both epidemiological studies and the diagnosis infection, especially in children. The use sampling evaluate specific H. IgG has advantages over serum, including reduced biohazard risk noninvasive collection. Oral fast involves minimal patient discomfort. Since children facilitate transmission simple, accurate, diagnostic...
The direct immunofluorescence technique using monoclonal antitoxoplasma antibodies was used to detect Toxoplasma organisms in 13 brain touch preparations and six smears of cerebrospinal fluid. For comparison, Giemsa-stained histologic sections the same cases were also studied. Positive results obtained from two acquired immunodeficiency syndrome (AIDS) with all three methods. cysts, pseudocysts, tachyzoites easily identified by technique, no false-positive encountered nine AIDS different...
Heterogeneity in strategies for survival and proliferation among the cells which constitute a tumour is driving force behind evolution of resistance to cancer therapy. The rules mapping tumour’s strategy distribution fitness individual can be represented as an evolutionary game. We develop game assay measure effective games co-cultures non-small cell lung are sensitive resistant anaplastic lymphoma kinase inhibitor Alectinib. not only quantitatively different between environments, but...
OBJECTIVES: To determine the test characteristics of gastric-juice ammonia concentration as measured by an ion-selective electrode and a rapid detection device for diagnosis Helicobacter pylori infection to assess relationship between severity gastritis. METHODS: Patients undergoing upper endoscopy had collection gastric juice that was tested using assay uses pH-indicating membrane. A receiver operating characteristic curve calculated concentration. Severity gastritis graded Sydney...
Internalization of epidermal growth factor (EGF) receptors by human A431 epidermoid carcinoma cells was studied at various culture densities. The extent EGF receptor internalization measured quantitation internalized 125I-EGF during incubation 37°C for 30 min. When cell density below 1×105 cells/cm2 active; 30-40% excess moles ligand over the surface were this period. However, when increased to above 1.5×105 cells/cm became less extensive, as only 30-50% bound underwent min incubation. In...
ABSTRACT Studies are difficult in areas lacking modern facilities due to the inability reliably collect, store, and ship samples. Thus, we sought evaluate use of a dry plasma collection device for seroepidemiology studies. Plasma was obtained by fingerstick using commercial (Chemcard Collection Device) serum (venipuncture) from individuals Kazakhstan. samples were air dried 15 min then stored desiccated foil zip-lock pouches at 4 6°C subsequently shipped United States ambient temperature....