A5016962524- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Sex work and related issues
- Pneumocystis jirovecii pneumonia detection and treatment
- Intimate Partner and Family Violence
- Global Maternal and Child Health
- Tuberculosis Research and Epidemiology
- Urologic and reproductive health conditions
- Female Genital Mutilation/Cutting Issues
- Complementary and Alternative Medicine Studies
- Poverty, Education, and Child Welfare
- Genital Health and Disease
- HIV-related health complications and treatments
- Infectious Diseases and Tuberculosis
- Opioid Use Disorder Treatment
- Ethnobotanical and Medicinal Plants Studies
Ministry of Health
2021-2025
Makerere University
2010-2025
Ministry of Health of the Russian Federation
2023
MUJHU Research Collaboration
2010-2015
University of Bahrain
2011
Johns Hopkins University
2009
Scale up of paediatric antiretroviral therapy in resource limited settings continues despite access to routine laboratory monitoring. We documented the weight and height responses HIV infected Ugandan children on highly active determined clinical factors associated with successful treatment outcomes. A prospective cohort were initiated HAART followed for 48 weeks. Body mass index age z scores(BAZ), height-for-age scores (WAZ & HAZ) calculated: CD4 cell % HIV-1 RNA measured at baseline every...
Persistently high HIV incidence among women, especially adolescent girls and young women (AGYW), have drawn the attention of national policymakers, donors, implementers in Sub-Saharan Africa to integration family planning (FP) programs. According several research studies, FP services could offer a holistic strategy address needs this demographic by including prevention approaches, particularly pre-exposure prophylaxis. Our study set out explore obstacles opportunities that AGYW faced...
Uganda implements interventions for injection drug use, but significant barriers hinder efforts to effectively reach and support persons who inject drugs (PWID). We describe characteristics of PWID, associated risk behaviour, inform the designing programmes that are tailored clients’ needs preferences. A cross-sectional survey (August 23 rd December 5 th , 2023) in Kampala interviewed 354 PWID (≥18-years) at selected venues(bars,lodges, street corners ghetto). Peer eductors counsellors...
Effective Prevention of Mother to child Transmission HIV (PMTCT) relies heavily on follow-up HIV-infected women and infants from antenatal, through postnatal, the end breastfeeding period. In Uganda, postnatal (PNC) remains below 50 % creating a missed opportunity for linkage comprehensive care early infant diagnosis (EID). We evaluated use infected peer mothers (peers), community lay persons Village health team (VHT) members improve PNC follow up EID in urban rural units.Study participants...
In Africa, herbal medicines are often used as primary treatment for Human immunodeficiency virus (HIV) related problems. Concurrent use of traditional (THM) with antiretroviral drugs (ARVs) is widespread among HIV infected patients. However, the extent THM not known in most settings Sub-Saharan Africa. This study aimed at determining prevalence and factors associated patients on highly active therapy (HAART) attending The AIDS Support Organization (TASO) Uganda. TASO a non-governmental...
To identify health facility and patient-specific factors associated with TB treatment default in HIV-infected patients, a clinic on the campus of Mulago National Referral Hospital Kampala, Uganda.Unmatched case-control study between March May 2009. Cases were patients known to have defaulted their anti-TB treatment, defined as patient who had documented discontinuation medication for two or more consecutive months due reasons other than physician's advice did not access care at another...
People who inject drugs (PWID) are at increased risk of HIV acquisition and often encounter barriers to accessing healthcare services. Uganda has high prevalence among PWID lacks integrated pre-exposure prophylaxis (PrEP) harm reduction Understanding experiences using services PrEP will inform strategies optimize integration that align with needs priorities. Between May 2021 March 2023, we conducted semi-structured interviews in Kampala, Uganda. We recruited participants without previous...
global studies indicate that sexual gender-based violence (SGBV) may increase during pandemics including COVID-19. The Mid-Eastern region in Uganda was of concern due to the high prevalence intimate partner among adolescent girls and young women (AGYW). Due limited data, we investigated factors associated with SGBV AGYW COVID-19 pandemic Eastern Uganda, April 2022.
Early HIV infant diagnosis and treatment have been shown to dramatically improve survival in infants. Despite these findings, infants accessing remain low Uganda. We describe the antiretroviral (ARV) drugs given Mulago Hospital prevention of mother-to-child transmission (PMTCT) program from January 2007 May 2009 its impact on early infection rates.Pregnant women identified as infected antenatal clinics received one following regimens: short-course ARV prophylaxis plus single-dose nevirapine...
To compare the response to a nevirapine (NVP)-based highly active antiretroviral therapy (HAART) in HIV-infected Ugandan children, exposed and nonexposed single-dose NVP (sd NVP) at birth.HIV-infected study children were initiated on stavudine/lamivudine/NVP as fixed dose combination. CD4 cell percent HIV-1 RNA documented baseline, 12, 24, 36, 48 weeks post-initiation of HAART.Ninety-two enrolled study, 44 sd NVP-exposed cohort. The median age enrollment was 1.7 years [interquartile range...
Abstract Background Injection Drug use is associated with increased HIV risk behaviour that may result in the transmission of and poor access to prevention treatment. In 2020, Uganda introduced ‘medication for opioid disorder (MOUD) treatment’ People who inject drugs (PWID). We analysed 12-month retention factors among PWID enrolled on MOUD treatment Kampala, Uganda. Methods conducted a retrospective analysis 343 OUD completed 14 days methadone induction from September 2020 July 2022....
Many of the countries in sub-Saharan Africa are still largely dependent on microscopy as mainstay for diagnosis tuberculosis (TB) including patients with previous history TB treatment. The available guidance management retreatment cases is focused bacteriologically confirmed leaving out those classified 'others'. Retreatment 'others' refer to all who were previously treated but unknown outcome that treatment or have returned negative pulmonary extra-pulmonary TB. This study was conducted 11...
To determine kinetics after single-dose nevirapine and the impact on HIV RNA [viral load (VL)] in maternal plasma breast milk (BM).Cohort of 120 HIV-1-infected pregnant Ugandan women received perinatal alone followed up with their infants through 24 weeks postdelivery. We assessed relationship concentration (tandem mass spectroscopy) HIV-1 VL (Roche AMPLICOR Kit, version 1.5) BM over time.At week 1 postpartum, NVP (≥10 ng/mL) was detected all 53 47 51 (92.2%) samples median (interquartile...
In 2012, Makerere University Johns - Hopkins University, and Mulago National Referral Hospital, with support from the Institute of Health (under Grant number: NOT AI-01-023) undertook operational research at Hospital PMTCT/PNC clinics. The study employed Peer Family Planning Champions to offer health education, counselling, triage aimed increasing identification, referral family planning (FP) uptake among HIV positive mothers attending clinic.The Champion Intervention improve FP was...
Abstract Background Uganda has registered a reduction in new HIV infections among children recent years. However, mother-to-child transmission of still occurs, especially pregnant women who present late. To eliminate this transmission, all HIV-positive should be identified during antenatal testing. We described newly pregnancy and postnatal period 2015–2018. Methods extracted surveillance data for as the reported through Health Management Information System from calculated proportions...
Abstract Background Uganda has implemented targeted interventions to address the rising burden of injection drug use, yet barriers persist in reaching persons who inject drugs (PWID). This study describes characteristics people drugs, physical and mental health states, associated risk behaviors, inform designing programs that are tailored client’s needs preferences. Methods A cross-sectional survey was conducted between August December 2023 at selected hotspots Kampala, interviewing 499 PWID...
Abstract Objectives To determine and compare the clinical immunologic outcomes for HIV ‐infected women initiated on antiretroviral therapy (ART), with without previous exposure to single‐dose nevirapine in MTCT ‐ P lus programme – K ampala, Uganda, from 2003 2011. Methods Retrospective comparison of prospectively collected programmatic data treatment among Ugandan women, prior sd NVP , who received NNRTI ‐based ART a median follow‐up 6 years. Results Of 408 programme, 289 (70.8%) were...
Abstract Background Global studies indicate that sexual gender based violence (SGBV) may increase during pandemics including the COVID-19. The Mid-Eastern region in Uganda was of a concern due to high prevalence intimate partner among adolescent girls and young women (AGYW) (13% 2016). Due limited data, we investigated factors associated with SGBV AGYW COVID-19 pandemic Eastern Uganda, April 2022. Methods We line listed all 10-24 years who obtained services at ten high-volume health...
Background: Children co-infected with Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) require concurrent treatment anti-tuberculosis drugs Antiretroviral therapy (ART).Drug interaction between nevirapine rifampicin leads to decreased levels.The impact of this drug-drug on virologic immunologic outcomes in the HIV -TB children has not been fully studied.A retrospective analysis was conducted compare response nevirapine-based ART regimen among HIV-infected Ugandan a containing anti-TB...