Photocurable, biocompatible liquid resins are highly desired for 3D stereolithography based bioprinting. Here we solidified a novel renewable soybean oil epoxidized acrylate, using laser printing technique, into smart and scaffolds capable of supporting growth multipotent human bone marrow mesenchymal stem cells (hMSCs). Porous were readily fabricated by simply adjusting the printer infill density; superficial structures polymerized acrylate significantly affected frequency speed. Shape...

Four dimensional (4D) printing is an emerging technology with great capacity for fabricating complex, stimuli-responsive 3D structures, providing potential tissue and organ engineering applications. Although the 4D concept was first highlighted in 2013, extensive research has rapidly developed, along more-in-depth understanding assertions regarding definition of 4D. In this review, we begin by establishing criteria printing, followed summary state-of-the-art technological advances field....

Metastasis is one of the deadliest consequences breast cancer, with bone being primary sites occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In study, we developed a matrix using bioprinting technology investigate interaction between cancer (BrCa) cells and stromal (fetal osteoblasts human marrow mesenchymal stem (MSCs)). A tabletop stereolithography bioprinter was employed fabricate series matrices consisting or MSCs encapsulated gelatin...

Nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing interaction between neural cells and biomaterials. In addition superior electrical conductivity, CNTs can provide nanoscale structures similar those present in natural environment. The primary objective this study is investigate proliferative capability differential potential stem (NSCs) seeded on a CNT incorporated scaffold.Amine functionalized multi-walled...

4D printing represents one of the most advanced fabrication techniques for prospective applications in tissue engineering, biomedical devices, and soft robotics, among others. In this study, a novel multiresponsive architecture is developed through stereolithography-based printing, where universal concept stress-induced shape transformation applied to achieve reprogramming. The light-induced graded internal stress followed by subsequent solvent-induced relaxation, driving an autonomous...

A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional grafts organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize during fabrication for modulating or improving cellular events. As service our authors readers, this journal provides supporting information supplied by the authors. Such...

Three-dimensional (3D) bioprinting is a rapidly emerging technique in the field of tissue engineering to fabricate extremely intricate and complex biomimetic scaffolds range micrometers. Such customized 3D printed constructs can be used for regeneration tissues such as cartilage, vessels, nerves. However, printing techniques often offer limited control over resolution compromised mechanical properties due short selection printable inks. To address these limitations, we combined...

Central nerve repair and regeneration remain challenging problems worldwide, largely because of the extremely weak inherent regenerative capacity accompanying fibrosis native nerves. Inadequate solutions to unmet needs for clinical therapeutics encourage development novel strategies promote regeneration. Recently, 3D bioprinting techniques, as one a set valuable tissue engineering technologies, have shown great promise toward fabricating complex customizable artificial scaffolds. Gelatin...

4D printing is a highly innovative additive manufacturing process for fabricating smart structures with the ability to transform over time. Significantly different from regular techniques, this study focuses on creating novel hierarchical micropatterns using unique photolithographic-stereolithographic-tandem strategy (PSTS) soybean oil epoxidized acrylate (SOEA) inks effectively regulating human bone marrow mesenchymal stem cell (hMSC) cardiomyogenic behaviors. The effect refers autonomous...

The ability to fabricate perfusable, small-diameter vasculature is a foundational step toward generating human tissues/organs for clinical applications. Currently, it highly challenging generate integrated with smooth muscle and endothelium that replicates the complexity functionality of natural vessels. Here, novel method directly printing self-standing, presented through combining tailored mussel-inspired bioink unique 'fugitive-migration' tactics, its effectiveness advantages over other...

Blood vessel damage resulting from trauma or diseases presents a serious risk of morbidity and mortality. Although synthetic vascular grafts have been successfully commercialized for clinical use, they are currently only readily available large-diameter vessels (>6 mm). Small-diameter (<6 mm) replacements, however, still present significant challenges worldwide. The primary objective this study is to create novel, tunable, small-diameter blood with biomimetic two distinct cell layers...

Osteochondral tissue has a complex graded structure where biological, physiological, and mechanical properties vary significantly over the full thickness spanning from subchondral bone region beneath joint surface to hyaline cartilage at surface. This presents significant challenge for tissue-engineered structures addressing osteochondral defects. Fused deposition modeling (FDM) 3D bioprinters present unique solution this problem. The objective of study is use FDM-based bioprinting...

A traumatic injury of peripheral nerves is serious clinical problem that may lead to major loss nerve function, affecting quality patient's life. Currently, autograft widely used reconstruct the gap. However, such surgical procedure suffers from many disadvantages including donor site morbidity and limited availability. In order address these issues, neural tissue engineering has focused on development synthetic scaffolds support bridging a larger gap improving generation. For this purpose,...

Like the morphology of native tissue fiber arrangement (such as skeletal muscle), unidirectional anisotropic scaffolds are highly desired a means to guide cell behavior in engineering. In contrast, contour-like staircases exhibit directional topographical cues and judged an inevitable defect fused deposition modeling (FDM). this study, we will translate staircase into effective bioengineering strategy by integrating FDM with surface coating technique (FCT) investigate effect on regulating...

Abstract In the late 1990s, Department of Civil and Mechanical Engineering at U.S. Military Academy (West Point) formulated a teaching model which guided training new faculty. The served faculty well as they provided instruction developed learning activities. remained unchanged for about 15 years until team conducted methodical review literature, reflected on desired outcomes, deliberated role that this played in achieving institution department's mission vision. result was an updated...

In article no. 1800101, Lijie Grace Zhang and co-workers present multiple responsive 4D printed architectures with great potential applications for neural tissue engineering. Even beyond the fourth dimension, scaffolds exhibit additional reversible shape transformation memory effects. By incorporating graphene, smart nerve guidance conduit shows outstanding multifunctional characteristics including physical guidance, chemical cues, dynamic self-entubulation, seamless integration.

Abstract The analysis of tendon repair suture techniques can help identify best practices for surgeons. Currently, a gap exists in the understanding biomechanics and failure utilizing traditional Whipstitch method as compared to construct that includes scaffold augment (FiberTag, Arthrex, Inc, Naples, FL). purpose this study was conduct biomechanical testing both FiberTag technique modes, locations, loads each technique. 30 ten-centimeter bovine tendons with nine-millimeters diameter were...

Abstract Current instruction of manufacturing processes at the United States Military Academy utilizes manual knee mills for milling instruction. However, Computer Numerical Control (CNC) Milling Machines are standard to modern industry and have potential modernize undergraduate engineering curriculum. The objective study is determine benefits limitations using a small affordable CNC machine, HAAS Desktop Mill, integrate machining into an level course. It was determined that it possible use...

Osteochondral tissue has a graded structure spanning from the subchondral bone region beneath joint surface to hyaline cartilage at surface. Biological, physiological, and mechanical properties over regions cross-section vary greatly; this provides significant challenge for tissue-engineered structures addressing osteochondral defects. The objective of research is investigate effects scaffold pore on mechanical, biological, physiological 3D printed engineered scaffolds. Our results indicate...

Abstract NOTE: The first page of text has been automatically extracted and included below in lieu an abstract Impacts Early Research Experience on Recruiting Retention Engineering One the premier events engineering curriculum is participation a summer internship program. United States Military Academy (USMA) developed program to promote academic activities beyond basic requirements. This recently opened students that have yet declare their major. intent original was enhance students’...