A5005370162- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Surgical site infection prevention
- Colorectal and Anal Carcinomas
- Statistical Methods in Clinical Trials
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advances in Oncology and Radiotherapy
- Mitochondrial Function and Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Testicular diseases and treatments
- Endometrial and Cervical Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Vascular Tumors and Angiosarcomas
- Reconstructive Surgery and Microvascular Techniques
- COVID-19 and healthcare impacts
University of Toronto
2020-2022
Princess Margaret Cancer Centre
2020-2022
Homi Bhabha National Institute
2020-2021
Tata Memorial Hospital
2016-2021
University Health Network
2020
Thomas Jefferson University
1999
<h3>Importance</h3> Radiotherapy combined with androgen deprivation therapy (ADT) is a standard of care for high-risk prostate cancer. However, the interplay between radiotherapy dose and required minimum duration ADT uncertain. <h3>Objective</h3> To determine specific threshold that provides distant metastasis-free survival (DMFS) benefit in patients cancer receiving external beam (EBRT) or EBRT brachytherapy boost (EBRT+BT). <h3>Design, Settings, Participants</h3> This was cohort study 3...
Objective/Hypothesis Extranodal extension (ENE) is an independent prognosticator in head–neck Squamous cell carcinoma (SCC). All patients with ENE, however, do not behave the same, and there a need for further risk stratification. This study evaluates prognostic significance of various grades ENE number nodes on overall survival (OS) oral cavity SCC (OCSCC). Study Design Retrospective cohort study. Methods Ninety‐four node‐positive OCSCC treated primary surgery appropriate adjuvant therapy...
<h3>Importance</h3> Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) can detect low-volume, nonlocalized (ie, regional or metastatic) prostate cancer that was occult on conventional imaging. However, the long-term clinical implications of PSMA PET/CT upstaging remain unclear. <h3>Objectives</h3> To evaluate prognostic significance a nomogram models an individual’s risk and to compare its performance with existing risk-stratification tools....
The optimal management strategy for high-risk prostate cancer and additional adverse clinicopathologic features remains unknown.To compare clinical outcomes among patients with after definitive treatment.This retrospective cohort study included (as defined by the National Comprehensive Cancer Network [NCCN]) at least 1 feature (defined as any primary Gleason pattern 5 on biopsy, T3b-4 disease, ≥50% cores biopsy results positive cancer, or NCCN ≥2 features) treated between 2000 2014 16...
Abstract Purpose Evaluate long‐term clinical outcomes, adverse effects, and evolving practice of interstitial brachytherapy (BT) for pediatric soft tissue sarcomas (STS). Methods From September 1984 to December 2014, 105 children (median age 10 years) were included. There 60 males 45 females. The majority (74%) had primary lesions. Synovial sarcoma (22%) was the most frequent histology. Treatment included wide local excision BT with or without external beam radiotherapy (EBRT). Eighty‐five...
To report an innovative technique of interstitial brachytherapy developed for treatment orbital soft tissue tumors.A 4-month-old child diagnosed with rhabdomyosarcoma orbit was treated multiagent chemotherapy (CTh) and brachytherapy. Pre-planning computed tomography (CT) images were obtained clinical target volume (CTV) defined using the pre-treatment magnetic resonance imaging (MRI). Brachytherapy plan generated deciding optimal catheter placement. With under general anesthesia, entry...
The coronavirus disease 2019 (COVID-19) pandemic has propelled health care workers to the front lines against pandemic. In addition anxiety related infection risks, trainees have additional burden of learning and career planning while providing in an uncertain rapidly changing environment. We conducted a survey evaluate practical psychosocial impact on radiation oncology fellows during first month
Abstract: The concept of "adaptive radiotherapy" (ART) was introduced more than 20 years ago. It refers to imaging feedback control strategies with treatment plan modification in response patient-specific variation during the course radiotherapy. ART is particularly relevant nasopharyngeal carcinoma (NPC) patients precision radiotherapy era since contemporary intensity-modulated (IMRT) combined chemotherapy could result significant volumetric alteration tumor and normal tissue course....
Stereotactic body radiotherapy (SBRT) is now considered the standard treatment for medically inoperable early-stage non-small lung cell cancer (ES-NSCLC).There a paucity of data related to outcomes with SBRT in ES-NSCLC from developing countries. We report early patients treated at our institute.Between 2007 and 2015, 40 consecutive histologically proven were SBRT. Median age was 71 years (range: 46-88 years) median Charlson comorbidity index (CCI) 3. The majority had stage I (70%) 45%...
To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension (ICE) treated induction chemotherapy (ICT) followed by chemo-intensity-modulated radiotherapy (CTRT) at tertiary center.We retrospectively analyzed 45 patients histologically proven, non-metastatic NPC ICE our institute between October 2008 and 2016. Patients were classified as minor or major ICE, based on extent ICE. All received 2-3 cycles taxane-based ICT regimen CTRT. Radiotherapy was...
371 Background: Objectives were to1) identify predictors of biochemical failure(BCF) -free survival (FFS) & distant metastases free-survival (DMFS) in high-risk prostate cancer (HRPC) patients treated with external beam radiotherapy (EBRT) or without androgen deprivation therapy (ADT); 2) assess the impact nodal irradiation escalation dose to volumes HRPC. Methods: Between Feb 2000 May 2011, 462 HRPC EBRT +/- ADT. This spanned an era technical development; prior 2002 conventional was...