A5030731989- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Education, Safety, and Science Studies
- Blood groups and transfusion
- Technology Use by Older Adults
- Prenatal Screening and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Teratomas and Epidermoid Cysts
- Tumors and Oncological Cases
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Genomics and Diagnostics
- Platelet Disorders and Treatments
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Assisted Reproductive Technology and Twin Pregnancy
- Diverse Approaches in Healthcare and Education Studies
- Neonatal and fetal brain pathology
- Healthcare cost, quality, practices
- Education and Learning Interventions
- Microtubule and mitosis dynamics
- Vascular Malformations and Hemangiomas
- Anorectal Disease Treatments and Outcomes
- Acute Lymphoblastic Leukemia research
Kanagawa Children's Medical Center
2019-2024
Boston Children's Hospital
2005
Nagano Children's Hospital
2005
Perinatal Institute
2005
Overall survival (OS) of patients with diffuse intrinsic pontine glioma (DIPG) is poor, radiation therapy (RT) the only intervention that transiently delays tumor progression. Hypofractionated RT and re-irradiation at first progression have gained popularity in improving quality life such patients.We performed a retrospective review children DIPG treated Kanagawa Children's Medical Center from 2000 to 2018.A total 24 cases were reviewed. Median age diagnosis was 6.3 years (1.6-14.0). Twenty...
Abstract Background Preclinical observations suggested a synergistic effect of sorafenib (SFN) and irinotecan (CPT‐11) in hepatoblastoma (HB). Thus, we conducted feasibility study fractionated CPT‐11 combined with SFN to develop new therapy against relapsed/refractory pediatric hepatic cancer (HC). Procedure The was originally designed as phase I, standard 3+3 dose‐finding evaluate dose‐limiting toxicities (DLTs) for the regimen optimal dose combination HC, including HB hepatocellular...
Abstract We present a case involving giant hemangioma of the fetal neck, prenatal diagnosis which was teratoma. A 32‐year‐old pregnant woman referred to our hospital at 31 weeks’ gestation owing solid mass neck and excessive amniotic fluid. The seemed be occupying almost entirely, extending nasopharyngeal cavity, mandible, surface left orbit shoulder. Based on sonographic magnetic resonance imaging (MRI) findings, teratoma made. Cesarean section performed 35.5 gestation, female infant...
ABSTRACT We present a fetus with progressive massive subcutaneous lymphangiomas leading to intrauterine death. A 28‐year‐old woman was referred our hospital because of precordial cystic mass the fetus. An ultrasound revealed extending from bilateral axillae anterior chest wall. At 18 weeks’ gestation, amniocentesis performed and karyotype found be normal 46, XY. Thereafter lesions increased in size gradually spread over body. Amniotic fluid decreased, pericardial, pleural effusion appeared,...
ABSTRACT We report two cases of a fetus with sirenomelia sequence which showed oligohydramnios and single umbilical artery. The first case was symelia apus only one leg. Prenatal diagnosis this possible. second dichorionic‐diamniotic twin pregnancy in had dipus fused lower extremities. the condition not made. In both cases, fetuses died shortly after birth from respiratory distress due to severe pulmonary hypoplasia. Absence urinary tract, imperforate anus, spine deformity were confirmed...
Summary Approximately 20% of patients with transient abnormal myelopoiesis (TAM) die due to hepatic or multiorgan failure. To identify potential new treatments for TAM, we performed in vitro drug sensitivity testing (DST) using the peripheral blood samples eight TAM. DST screened 41 agents cytotoxic properties against TAM blasts. Compared reference healthy subjects, blasts were more sensitive glucocorticoids, mitogen‐activated protein kinase (MAP2K) inhibitor trametinib, and cytarabine. Our...
Abstract Background Abnormal blood cell counts are characteristic of patients with Down syndrome and transient abnormal myelopoiesis (TAM). Although some TAM experience prolonged anemia or thrombocytopenia, hematological factors predicting count recovery have not been reported yet. The aim this study was to investigate the influencing platelet normalization in TAM. Methods A retrospective review medical records 21 admitted neonatal intensive care unit at Kanagawa Children’s Medical Center...