A5063384279- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Neonatal and fetal brain pathology
- Endometrial and Cervical Cancer Treatments
- Reproductive Physiology in Livestock
- Congenital Anomalies and Fetal Surgery
- Prenatal Screening and Diagnostics
- Cervical Cancer and HPV Research
- Congenital Diaphragmatic Hernia Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Uterine Myomas and Treatments
- Preterm Birth and Chorioamnionitis
- Estrogen and related hormone effects
- Heart Rate Variability and Autonomic Control
- Cardiovascular Issues in Pregnancy
- Inflammatory mediators and NSAID effects
- Gestational Diabetes Research and Management
- Influenza Virus Research Studies
- Mechanical Circulatory Support Devices
Ito Hospital
2024
Japan Community Healthcare Organization
2024
Kitasato University
2013-2023
Kitasato University Hospital
2014-2021
National Sagamihara Hospital
2020
National Center For Child Health and Development
2014
Infant
2013
Nagano Children's Hospital
2001-2005
Wake Forest University
2005
Shinshu University
2005
Abstract The ‘ C linical G uidelines for O bstetrical P ractice, 2011 edition’ were revised and published as a 2014 edition (in J apanese) in A pril by the apan S ociety of bstetrics ynecology ssociation bstetricians ynecologists. aims this publication include determination current standard care practices pregnant women apan, widespread use practices, enhancement safety obstetrical practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding...
To better understand the role of human leukocyte antigen (HLA)-G in regulating T helper (Th)1/Th2 cytokine balance, one key conditions determining fate pregnancy, we asked whether presence HLA-G protein altered release cytokines from both decidual mononuclear cells and peripheral blood (PBMCs).The amounts released PBMCs were compared or absence HLA-G-expressing cells.When cocultured with cells, tumor necrosis factor-alpha interferon-gamma decreased, while interleukin (IL)-4 was increased,...
Abstract Angiogenesis is critical in maintenance of endometrial tissues. Here, we examined the role VEGF receptor 1 (VEGFR1) signaling angiogenesis and tissue growth an endometriosis model. Endometrial fragments were implanted into peritoneal wall mice, microvessel density (MVD) determined. from wild-type (WT) mice grew slowly with increased determined by CD31 + MVD, peaking on Day 14. When tissues WT transplanted VEGFR1 tyrosine kinase-knockout implant suppressed 14 compared implants a...
Abstract In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of MΦ is unclear. CD206 positive (+) classified one type and known to produce cytokines chemokines. present study, we used diphtheria toxin receptor mice, which enable deplete CD206+ cells with (DT) an endometriosis mouse model. The depletion decreased total weight endometriotic-like lesions significantly ( p < 0.05). DT group, a lower proliferation decrease angiogenesis were observed. mRNA levels...
Abstract: The purpose of our study was to examine the feasibility long‐term extrauterine incubation an isolated premature fetus in artificial amniotic fluid with arteriovenous extracorporeal circulation. Two goat fetuses (age 120 and 128 days) were incubated isothermal incubator membrane oxygenation via umbilical vessels. We administered pancuronium bromide suppress fetal movement swallowing because have been implicated deterioration during incubation. maintained stable circulatory...
Ontogenic changes in baseline and 24-h rhythms of fetal arterial blood pressure (FABP) heart rate (FHR) their regulation by the adrenal were studied 18 sheep chronically instrumented at 109–114 days gestation (GA). In long-term study, FABP FHR continuously recorded from 120 GA to spontaneous term labor (>145 GA) five animals. Peak times (PT) amplitudes (Amp) cosinor analysis compared 120–126, 127–133, 134–140 GA. Consistent, significant linear increases decreases observed all fetuses....
Abstract: Previously, this group reported on a system of extrauterine incubation goat fetus, in which the fetus is surrounded by artificial amniotic fluid and connected to circuit with an ECMO (extracorporeal membrane ox‐ygenator) umbilical arteries veins. The following summary recent progress using improved method catheterization new that included dialyzer within circuit. Nine fetuses were used experiment. Six goats successfully incubated; duration their was 146.5 ± 61.3 h (mean SD)....
We characterized the detailed hemodynamics of fetal blood pressure, heart rate, common umbilical flow, and femoral flow responses to partial compression cord tested hypothesis that repeated modulates cardiovascular in 10 chronically instrumented sheep at approximately 130 days gestation. In five fetuses (group I), was induced 12 times, each for 5 min 15-min intervals. Each reduced by 50% produced modest falls pH (7.33 +/- 0 7.29 0) arterial PO2 (21.1 0.2 16.8 mmHg) a mild increase PCO2 (49.9...
The concept of fetal programming is an area that now under rigorous investigation in many laboratories throughout the world. We need to engender a fascination all segments society, not just pregnant women, about life womb.Everyone needs understand improving condition fetus will have personal, social and economic benefits. time has come realize that, sense, it women who are but family whole society.
Abstract Aim The aim of our study was: (i) to investigate whether transversus abdominis plane ( TAP ) block confers additional analgesic effects epidural morphine alone; and (ii) determine plasma levels local anesthetics after in post‐cesarean women. Material Methods subjects were parturients undergoing cesarean section under combined spinal‐epidural anesthesia. Morphine (2 mg) was administered the space close end surgery. Women who desired allocated group. did not undergo control In group,...
Sphingosine 1-phosphate (S1P), an inflammatory mediator, is abundantly contained in red blood cells and platelets. We hypothesized that the S1P concentration peritoneal cavity would increase especially during menstrual phase due to reflux of blood, investigated human fluid (PF) from 14 non-endometriosis 19 endometriosis patients. Although relatively small number samples requires caution interpreting results, PF was predominantly increased compared non-menstrual phase, regardless presence or...
Cephalopagus twinning, an extremely rare type of conjoined twins, is characterized by the anterior union upper half body, with two faces each situated on opposite side a head. The prognosis for cephalopagus twins poor because surgical separation not option. Thus early prenatal diagnosis important to provide opportunity pregnancy termination if desired. However, in many instances, are misdiagnosed as singleton extreme degree fusion which makes accurate demonstration abnormalities very...
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during Endometrial fragments from wild-type (WT) mice transplanted into peritoneal wall host WT (WT→WT) developed well and displayed enhanced associated with increases mRNA levels VEGF-C VEGF-D. Compared mice, implant size were reduced, when endometrial lacking VEGFR1 tyrosine kinase (TK) domain (TK-/-) TK-/-...
The present study was designed to characterize effects of inhibiting PG production by infusing nimesulide (CAS 51803–78-2) on PGE2 and expression uterine labor-related genes in pregnant sheep. Myometrium, endometrium, placenta were collected following 6 h iv or vehicle infusion. Infusions commenced 9 after onset spontaneous term labor. Tissues also from control ewes not measured fetal plasma RIA. ER, OTR, Hsp 70 90, cPLA2, PGHS-2 messenger RNA (mRNA) abundance myometrium, quantified Northern...