A5007556472- Immunotherapy and Immune Responses
- Memory and Neural Mechanisms
- Treatment of Major Depression
- Schizophrenia research and treatment
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- COVID-19 and Mental Health
- Dementia and Cognitive Impairment Research
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Spatial Cognition and Navigation
- Preterm Birth and Chorioamnionitis
- Pelvic floor disorders treatments
- Monoclonal and Polyclonal Antibodies Research
- Posttraumatic Stress Disorder Research
- Categorization, perception, and language
- Tryptophan and brain disorders
- Health disparities and outcomes
- Psychosomatic Disorders and Their Treatments
- vaccines and immunoinformatics approaches
- Advancements in Transdermal Drug Delivery
- Perfectionism, Procrastination, Anxiety Studies
- Female Genital Mutilation/Cutting Issues
- Transcranial Magnetic Stimulation Studies
York University
2021-2024
Toronto Rehabilitation Institute
2020-2023
University Health Network
2020-2023
Genocea (United States)
2020-2022
University of Toronto
2017-2020
Women's College Hospital
2020
Mount Sinai Hospital
2020
University College London
2018-2019
UNSW Sydney
2016-2019
University of Hong Kong
2014-2018
Ketamine research in depression has mostly used intravenous, weight-based approaches, which are difficult to translate clinically. Intranasal (IN) ketamine is a promising alternative but no controlled data been published on the feasibility, safety and potential efficacy of repeated IN treatments.This randomised, double-blind, placebo-controlled pilot study compared 4-week course eight treatments 100 mg or 4.5 midazolam. Each treatment was given as 10 separate sprays, self-administered 5 min...
Abstract Pathological changes in the medial temporal lobe (MTL) are found early stages of Alzheimer's disease (AD) and aging. The earliest pathological accumulation tau colocalizes with areas MTL involved object processing as part a wider anterolateral network. Here, we sought to assess diagnostic potential memory for locations iVR environments individuals at high risk AD dementia (amnestic mild cognitive impairment [aMCI] n = 23) compared age‐related decline. Consistent our primary...
Objective Throughout the COVID-19 pandemic, there have been concerns about mental health of care workers (HCW). Although numerous studies investigated level distress among HCW, few explored programs to improve their well-being. In this paper, we describe implementation and evaluation a program support HCW at University Health Network (UHN), Canada's largest healthcare network. Methods Using quality improvement approach, conducted needs assessment then created evaluated modified stepped-care...
Background Relapse is distressingly common after the first episode of psychosis, yet it poorly understood and difficult to predict. Investigating changes in cognitive function preceding relapse may provide new insights into underlying mechanism psychosis. We hypothesized that fully remitted first-episode psychosis patients was preceded by working memory deterioration. Method Visual verbal were monitored prospectively a 1-year randomized controlled trial assigned medication continuation...
Abstract Background The mental health of healthcare workers (HCWs) has been at the forefront throughout COVID-19 pandemic. While workplace-based support programs have developed in hospitals globally, few systematically collected data. critical to their success, information on these and experience providers (MHP) who colleagues is limited. objective this study was explore experiences MHP caring for HCW within a novel program during pandemic, provide insights facilitators, areas improvement...
Abstract We investigated the use of a novel lipid nanocapsule, Interbilayer-Crosslinked Multilamellar Vesicles (ICMV), for mucosal vaccine delivery. ICMV co-encapsulated with MPLA and/or polyI:C as adjuvants, was used to vaccinate mice using model antigen and SIV-gag epitopes. When delivered via lungs, we found that ~60-fold more transported draining lymph nodes than equivalent subcutaneous vaccination, mediated by vast number presenting cells in lungs. Potent CD8 T-cell response elicited...
Abstract Nanoparticles (NP) are promising delivery vehicles for vaccines that promote humoral and cellular immunity in concert. We recently developed a novel lipid-based NP vaccine system, termed interbilayer-crosslinked multilamellar vesicles (ICMVs). ICMVs efficiently entrap co-deliver antigens molecular adjuvants to lymphoid tissues, initiating potent immune responses. were synthesized by fusing liposomes containing antigen into vesicles, followed bilayer-to-bilayer crosslinking of lipid...
Abstract Mucosal vaccines offer needle-free administration and can stimulate immune responses systemically at mucosal sites. “Vectorless” based on antigens packaged in synthetic nanoparticles (NPs) potential advantages manufacturing, enhanced safety, lack of anti-vector responses. To this end, we tested the ability lipid NPs encapsulating ovalbumin or SIV-gag epitopes with Toll-like receptor agonists to immunity following pulmonary vaccination mice. CD11c+B220+MHC-II+CD205+ DCs...