A5022215029- Toxoplasma gondii Research Studies
- Hepatitis B Virus Studies
- Growth Hormone and Insulin-like Growth Factors
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Otolaryngology and Infectious Diseases
- Ubiquitin and proteasome pathways
- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Reproductive Physiology in Livestock
- Histone Deacetylase Inhibitors Research
- Herpesvirus Infections and Treatments
- Metabolism, Diabetes, and Cancer
Beltsville Agricultural Research Center
2016-2020
Harvard University
2020
Massachusetts General Hospital
2020
Abstract Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions of osteocytic Sclerostin (encoded Sost ) expression stimulates new formation. However, molecular steps linking mechanotransduction and suppression remain unknown. Here, we report that class IIa histone deacetylases (HDAC4 HDAC5) required for...
Abstract Toxoplasma gondii , the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. forms cysts in vitro that induce oocysts cats, gold standard criterion for cysts. These highly express cytochrome b . Using these models, envisioned, then created, 4-(1 H )-quinolone scaffolds target...
Multiple analogs of parathyroid hormone, all which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1-34 [TPTD]), long-acting PTH (LA-PTH) show distinct biologic effects respect skeletal mineral metabolism endpoints, mechanistic basis these clinically-important differences remains incompletely understood. Previous work has revealed that differential signaling kinetics conformation...
An amendment to this paper has been published and can be accessed via a link at the top of paper.