A5030669304- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Psychosomatic Disorders and Their Treatments
- Breastfeeding Practices and Influences
- Body Image and Dysmorphia Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological disorders and treatments
- Interprofessional Education and Collaboration
- Health Literacy and Information Accessibility
- Endometriosis Research and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neurosurgical Procedures and Complications
- Whipple's Disease and Interleukins
- Clinical Reasoning and Diagnostic Skills
- Vestibular and auditory disorders
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Ophthalmology and Eye Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Vagus Nerve Stimulation Research
- Mobile Health and mHealth Applications
- Parkinson's Disease Mechanisms and Treatments
Charité - Universitätsmedizin Berlin
2020-2025
Freie Universität Berlin
2022-2024
Humboldt-Universität zu Berlin
2022-2024
Medizinische Hochschule Hannover
2018
Background: German authorities reimburse migraine prevention with erenumab only in patients who previously did not have therapeutic success at least five oral prophylactics or contraindications to such. In this real-world analysis we assessed treatment response chronic (CM) failed and, addition, onabotulinumtoxinA (BoNTA). Methods: We analyzed retrospective data of 139 CM one injection from two headache centers. Patients respond sufficiently had β-blockers, flunarizine, topiramate,...
National and international guidelines recommend stopping migraine prophylaxis with CGRP(-receptor) monoclonal antibodies after 6-12 months of successful therapy. In this study, we aimed to analyze the course for four cessation use.This longitudinal cohort study included patients who received a CGRP-(receptor) antibody ≥8 before treatment cessation. We analyzed headache data in four-week period prior mAb initiation (baseline), month last injection, weeks 5-8 13-16 treatment. Primary endpoint...
Abstract Background Comprehensive clinical data regarding factors influencing the individual disease course of patients with movement disorders treated deep brain stimulation might help to better understand progression and develop individualized treatment approaches. Methods The core set was developed by a multidisciplinary working group within German transregional collaborative research network ReTune. development followed standardized methodology comprising review available evidence,...
Migraine frequency increases after the cessation of successful preventive treatment with CGRP(-receptor) monoclonal antibodies (mAbs). In this study, we aimed to evaluate course migraine resumption.Patients migraine, who started same CGRP(-R) mAb a three-month drug holiday were included in analysis. We collected headache data at four prospective visits: 1) during weeks before initial (baseline); 2) last injection; 3) 13-16 holiday; 4) 9-12 restart. Outcomes changes monthly days (MMD), (MHD),...
Migraine and sleep disorders share a bidirectional relationship, but little is known about the specific association between migraine rapid eye movement (REM) behaviour disorder (RBD). The aim was to assess prevalence of RBD associated clinical characteristics in adults with migraine.
Abstract Objective Migraine, endometriosis, and the comorbidity of both are frequent pain disorders special relevance for women. The neuropeptide calcitonin gene‐related peptide (CGRP) is critically involved in migraine, circumstantial evidence suggests a role endometriosis. We assessed CGRP levels at different times menstrual cycle four groups: healthy women, women with migraine or endometriosis both. Methods Women episodic histologically confirmed were recruited from specialized centers....
Migraine preventive treatment with CGRP(-receptor) monoclonal antibodies (mAbs) has a positive effect on patients' health-related quality of life (HRQoL). The German guidelines recommend discontinuing successful mAbs after 6-12 months. We aimed to evaluate headache-specific and generic HRQoL for three months discontinuation mAb treatment.We conducted prospective, longitudinal cohort study, including patients migraine 8-12 therapy CGRP(-R) before planned attempt. was assessed at the time last...
Discontinuation of treatment with monoclonal antibodies (mAb) targeting the Calcitonin Gene-Related Peptide (CGRP) pathway leads to an increase in migraine frequency. We aimed assess changes free and total CGRP plasma concentrations after discontinuation CGRP(-receptor) mAbs. This prospective analysis included 59 patients (n = 25 erenumab, n galcanezumab, 9 fremanezumab) who discontinued mAbs ≥8 months treatment. Patients were visited at time last mAb injection (V1) 16 weeks later (V2). For...
To assess the clinical spectrum of central nervous system (CNS) involvement as well cerebrospinal fluid (CSF) and neuroimaging findings in patients with Whipple's disease (WD) to analyze association neurological symptoms CSF imaging findings.Neurological was retrospectively analyzed a series 36 diagnosed WD at single center between 1992 2019. Findings 81 comprehensive examinations from patients, including polymerase chain reaction (PCR) tests for Tropheryma whipplei (TW) 35 were...
Lockdown measures due to the COVID-19 pandemic have led lifestyle changes, which in turn may an impact on course of headache disorders. We aimed assess changes primary characteristics and factors during lockdown Germany using digital documentation mobile application (app) M-sense. analyzed data smartphone users, who entered daily app 28-day period before (baseline) first 28 days (observation period). This analysis included change monthly (MHD) observation compared baseline. also assessed...
Background Smartphone-based apps represent a major development in health care management. Specifically headache care, the use of electronic diaries via has become increasingly popular. In contrast to soaring volume available data, scientific these data resources is sparse. Objective this analysis, we aimed assess changes and migraine frequency, intensity, acute medication among people who showed daily diary as implemented freely basic version German commercial app, M-sense. Methods The...
Migraine aura, near-death experiences (NDEs), and rapid eye movement (REM) sleep intrusions might share common mechanisms. Here, we investigated the prevalence of NDEs REM in people with migraine. We hypothesized that are more prevalent migraine patients aura than those without.We conducted a prospective cross-sectional cohort study at tertiary headache center, based on prespecified sample size (n = 808). completed series questionnaires, including questions about demographic characteristics,...
Abstract Objective Alice in Wonderland Syndrome (AIWS) is a sensory disorder characterized by distorted somatosensory and/or visual perception. Additionally, distortion of time perception and symptoms derealization/depersonalization may occur. AIWS frequently associated with migraine. However, its prevalence, clinical characteristics remain poorly understood. Here, we investigated the prevalence features individuals We hypothesized more frequent migraine patients aura than those without...
Background: The aim of this study was to assess usability and identify possible challenges in the implementation National Competence Based Catalogue Learning Objectives for Undergraduate Medical Education (NKLM) among medical educators. Methods: A comprehensive survey experienced educators (responsible teaching content didactical development their module/field) based on System Usability Scale (SUS) carried out focusing awareness, NKLM. Results: questionnaire completed by 52 64 addressed Most...
The representation of migraine in the media is stereotypical. Standard images attacks display stylish young women holding their head a pain pose. This may contribute to social stigmatization patients with migraine.We aimed analyze how and health care workers perceive online migraine.The study consisted an anonymous web-based survey at Headache Center Charité - Universitätsmedizin Berlin (migraine group) employees students our university (health group). A total 10 frequently used Adobe Stock...
<sec> <title>BACKGROUND</title> Smartphone-based apps represent a major development in health care management. Specifically headache care, the use of electronic diaries via has become increasingly popular. In contrast to soaring volume available data, scientific these data resources is sparse. </sec> <title>OBJECTIVE</title> this analysis, we aimed assess changes and migraine frequency, intensity, acute medication among people who showed daily diary as implemented freely basic version German...
<sec> <title>BACKGROUND</title> The representation of migraine in the media is stereotypical. Standard images attacks display stylish young women holding their head a pain pose. This may contribute to social stigmatization patients with migraine. </sec> <title>OBJECTIVE</title> We aimed analyze how and health care workers perceive online <title>METHODS</title> study consisted an anonymous web-based survey at Headache Center Charité – Universitätsmedizin Berlin (migraine group) employees...