A5064684644- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- CAR-T cell therapy research
- Acute Ischemic Stroke Management
- Virus-based gene therapy research
- Stroke Rehabilitation and Recovery
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Statistical Methods and Inference
- Obesity, Physical Activity, Diet
- Infectious Diseases and Mycology
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Neuroscience of respiration and sleep
- Adenosine and Purinergic Signaling
Cincinnati Children's Hospital Medical Center
2014-2025
Universiti Sains Malaysia
2024
Malacca General Hospital
2024
Children's Medical Center
2022
Hospital Sultanah Bahiyah
2021
UCSF Helen Diller Family Comprehensive Cancer Center
2018-2019
The University of Texas MD Anderson Cancer Center
2011-2018
University of California, San Francisco
2018
Raja Isteri Pengiran Anak Saleha Hospital
2017
Memorial Hermann–Texas Medical Center
2011
Abstract Purpose: Patients with resected, local–regionally advanced, head and neck squamous cell carcinoma (HNSCC) have a one-year disease-free survival (DFS) rate of 65%–69% despite adjuvant (chemo)radiotherapy. Neoadjuvant PD-1 immune-checkpoint blockade (ICB) has demonstrated clinical activity, but biomarkers response effect on remain unclear. Methods: Eligible patients had resectable the oral cavity, larynx, hypopharynx, or oropharynx (p16-negative) stage T3-T4 and/or two more nodal...
ABSTRACT: Context: Few studies have examined the prevalence of overweight status and physical inactivity among children adolescents living in rural America. Purpose: We urban differences US children. Methods: Data were drawn from 2003 National Survey Children's Health, restricted to aged 10‐17 (unweighted N = 47,757). Overweight was defined as gender‐ age‐specific body mass index (BMI) values at or above 95th percentile. Physical using parentally reported moderate‐to‐vigorous intensity...
Little is known about how acculturation may influence participation in leisure-time physical activity and obesity among adolescents. The objective of this study was to examine these associations Hispanic adolescents.Data were drawn from the 2003 National Survey Children's Health, restricted adolescents aged 10-17 (n=4704). Acculturation assessed by proxy measures (generation status language spoken at home). Adolescents who not reported engage lasting least 20 minutes, that vigorous enough...
Background and Purpose— Perfusion CT has been used to assess the extent of blood–brain barrier breakdown. The purpose this study was determine predictive value permeability measured using perfusion for development malignant middle cerebral artery infarction requiring hemicraniectomy (HC). Methods— We retrospectively identified patients from our stroke registry who had were evaluated with admission CT. Blood–brain blood volume maps generated infarct volumes calculated. Clinical radiographic...
Abstract Prenatal tobacco smoke exposure (TSE) and prematurity are independent risk factors for abnormal neurodevelopment. The objectives were to compare differences in Bayley-III cognitive, language, motor scores at 2 years corrected age (CA) 395 infants born very preterm (≤ 32 weeks gestation) with without prenatal TSE. We performed multivariable linear regression analyses examine associations between TSE neurodevelopmental outcomes a mediation analysis estimate direct effects of on...
The efficacy of cetuximab is poor in metastatic head and neck squamous cell carcinoma (HNSCC). Cetuximab initiates natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity, with resultant recruitment immune cells suppression antitumor immunity. We hypothesized that adding an immune-checkpoint inhibitor (ICI) could overcome this lead to enhanced response.A phase II study durvalumab HNSCC was conducted. Eligible patients had measurable disease. Patients who received both ICI...
Tobacco use remains a significant global public health challenge, with considerable health, social, and economic consequences. In Malaysia, anti-smoking campaigns like the long-standing “Tak Nak Merokok” 2019 “Speak Out” campaign have raised awareness about smoking dangers, empowering non-smokers to reprimand smokers protect themselves. However, understanding smokers’ attitudes toward these is essential for improving their effectiveness. This study aims investigate perception of that...
Uncontrolled hemorrhage is the most preventable cause of death following traumatic injury; children may be called to act as bystanders when control necessary. The earliest age that can learn remains undetermined. We aimed identify whether aged 8 12 years and how use a combat application tourniquet (CAT) appropriately place tighten it achieve control. conducted prospective study old. A trained facilitator taught CAT placement on manikins in small group sessions. After each session, we...
ABSTRACT Background Limited research exists on the burden of extremity fractures in Sub‐Saharan Africa. Underreporting is likely, as patients often seek out traditional bonesetters (TBSs). This study aims to determine annual incidence and impact fractures, alongside health‐seeking behavior rural Tanzania. Methods We conducted a cross‐sectional household survey Rorya district, Tanzania, enrolling 497 households with 2667 members, using spatial random sampling. surveyed heads regarding access...
Patients with intracerebral hemorrhage (ICH) are at high risk for development of deep venous thrombosis. Current guidelines state that low-dose subcutaneous low molecular weight heparin or unfractionated may be considered 3 to 4 days from onset. However, insufficient data exist on hematoma volume in patients ICH before and after pharmacological thrombosis prophylaxis, leaving physicians uncertainty regarding the safety this practice.We identified our stroke registry (June 2003 December 2007)...
Abstract Background. EGFR and Src are frequently activated in non-small cell lung cancer (NSCLC). In preclinical models, combining inhibition has additive synergistic effects. We conducted a phase I/II trial of the combination inhibitor dasatinib with erlotinib to determine maximum tolerated dose (MTD), pharmacokinetic drug interactions, biomarkers, efficacy NSCLC. Methods. The I 3+3 dose-escalation study enrolled patients solid tumors MTD. II advanced NSCLC who had undergone no previous...
Locoregional relapse in patients with head and neck squamous cell carcinoma (HNSCC) is common, approaching 50% for some subsites despite multimodality therapy. Salvage surgery the standard of care, but able to achieve durable control only a minority patients. While adjuvant radiotherapy or chemo-radiotherapy offered select patients, this approach can be prohibitively toxic. Given activity tolerability programmed death-1 inhibitors metastatic HNSCC, we investigated safety efficacy nivolumab...
Background Dedifferentiated chondrosarcoma remains a significant therapeutic challenge. Studies performed to date have not identified efficacious chemotherapy regimens for this disease. Questions/purposes We sought (1) evaluate the disease-specific survival at 2 and 5 years of patients with dedifferentiated chondrosarcoma; (2) assess prognostic variables (both patient- treatment-related), including use ifosfamide, that relate survivorship; (3) specific toxicities associated ifosfamide use....
ABSTRACT Objectives: The purpose of this study was to compare national estimates drug use and exposure violence between rural urban teens. Methods: Twenty‐eight dependent variables from the 2003 Youth Risk Behavior Survey were used violent activities, victimization, suicidal behavior, tobacco use, alcohol illegal across rural, urban, suburban teens country. Results: Overall, equally or more likely than both report experiencing many measures suicide behaviors, use. Among all teens, nonwhites...
In non-small cell lung cancer (NSCLC) treatment, radiotherapy responses are not durable and toxicity limits therapy. We find that AM-101, a synthetic benzodiazepine activator of GABA(A) receptor, impairs the viability clonogenicity both primary brain-metastatic NSCLC cells. Employing human-relevant ex vivo ‘chip’, AM-101 is as efficacious docetaxel, chemotherapeutic used with for advanced-stage NSCLC. vivo, potentiates radiation, including conferring significant survival benefit to mice...