A5111013152- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Extracellular vesicles in disease
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Congenital limb and hand anomalies
- Hedgehog Signaling Pathway Studies
- Fungal Infections and Studies
- Anatomy and Medical Technology
- Cardiovascular Conditions and Treatments
- Cancer-related molecular mechanisms research
- Tumors and Oncological Cases
- Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Plant Pathogens and Fungal Diseases
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Soft tissue tumor case studies
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Congenital Heart Disease Studies
First Affiliated Hospital of Anhui Medical University
2024
South China University of Technology
2024
Southwest University
2024
Second Hospital of Shanxi Medical University
2012-2023
Shanxi Medical University
2012-2023
Wenzhou Medical University
2011
Dongyang People's Hospital
2011
Long non-coding RNAs (LncRNAs) have been implicated as critical regulators of cancer tumorigenesis and progression. However, their functions molecular mechanisms in colorectal (CRC) still remain to be further elucidated.
The clinical manifestations of PI4KA-related disorders are characterized by considerable variability, predominantly featuring neurological impairments, gastrointestinal symptoms, and a combined immunodeficiency. aim this study was to delineate the novel spectrum PI4KA variants detected prenatally assess their influence on fetal development. A thorough ultrasound screening conducted, supplemented both antenatal post-abortion magnetic resonance imaging (MRI) studies. Novel were through Whole...
Abstract Co-deletion of the MTAP gene with CDKN2A gene, which is found in approximately 15% all cancers, results sensitization to MAT2A inhibition and provides an option for therapeutic intervention. The encouraging clinical activity IDE397 further proof-of-concept inhibitors treatment MTAP-deficient cancers. Here, we describe SY-9453 as a novel potent inhibitor. In biochemical assay, potently inhibited enzyme IC50 0.5 nM. HCT116 MTAP-/- cells, showed very strong cellular SAM production...
The main treatment for congenital hemivertebra is posterior hemivertebrectomy with bilateral transpedicular fixation. To date, studies describing unilateral fusion are few, especially in younger children. modified method by combined instrumentation and was described. purpose to present the clinical radiological outcome of children less than 10 years treated scoliosis instrumented fusion.A study 43 consecutive patients through Jan. 2006 Mar. 2013 hemivertebrae performed. Patients undergoing...
Abstract Background The management of thoracolumbar burst fractures traditionally involves posterior pedicle screw fixation, but it has some drawbacks. aim this study is to evaluate the clinical and radiological outcomes patients with fractures. They were treated by a modified technique that monoaxial screws instrumentation distraction-compression technology assisted end plate reduction. Methods From March 2014 February 2016, retrospective including 42 consecutive was performed. had...
Hemivertebrae, which are the most frequent cause of congenital scoliosis, pose a challenge in terms prognosis and therapy. The current gold standard treatment scoliosis due to lumbar thoracic hemivertebra would be resection short level posterior spinal fusion. Paucity literatures reported for by convex fusion with excision.The patient was first noticed have problem at 7 years age. A radiograph showed two full segment respectively T10, between L4 L5, spine deviating right side. No given, but...
An animal study with immature sheep to evaluate the effects of a multisegment growth guidance rod (MSGGR) on spine growth.To determine whether can still grow after MSGGR fixation.The disadvantages for current growing techniques are that they partially correct only spinal curve and have little control apex curve. The rigidity procedure may also interfere final correction. Current systems complex not always affordable, especially in developing world. Newer, more inexpensive provide...
Abstract Background Congenital scoliosis caused by failure of multiply vertebral segmentation with concave fused rib or unsegmented bar combined contralateralhemivertebra is usually rigid and produces enormous asymmetric growth. Fusionless techniques have less advantage come some complications. Paucity data was reported for children complex congenital using two-staged osteotomy surgery. Methods From 2006 to 2016, 11 patients than 10 years old undergoing two staged surgery were...
To investigate the structural abnormalities, genetic results, and postnatal clinical outcomes of fetuses with bovine aortic arch (Bovine Aortic Arch, BAA) to provide a basis for prenatal counseling management.
Abstract Background Two ipsilateral hemivertebrae is less common and presents severe growth imbalance caused by the vertebral anomalies. However, there a paucity of reports regarding to two thoracolumbar hemivertebrae. The purpose present study evaluate long-term outcomes posterior surgical correction thoraco-lumbar spine deformity Methods From 2006 2014, total 14 consecutive pediatric patients with congenital were treated excision short segment fusion. following parameters measured: coronal...
A 13-year-old boy who had hump-back was taken to the hospital. The whole spine posteroanterior and lateral radiograph showed failures of segmentation from T5 T8 vertebra, as well laminae fusion, diagnosed congenital thoracic kyphoscoliosis. Spinal fusion surgery suggested because potential progress segmental kyphosis. However, unusual imaging revealed that four cavity compartments were separated by two deformed ribs extending inferolaterally in bilateral hemithorax (figure 1A). Figure 1...
To evaluate the curative effect of one‐stage posterior debridement and osteotomy parallel to endplates for reconstruction, deformity correction, tuberculosis control on treating spinal graded GATA III. From July 2012 December 2017, there were 36 cases from Second Hospital Shanxi Medical University with thoracic lumbar III, in which we used reconstruction treatment,16 males 20 females. The local Cobb angles kyphosis all patients are greater than or equal 20.The age varied 28 months 72 years...
Cryptococcosis is a life-threatening fungal disease that usually present as an opportunist infection in immunocompromised hosts, and Cryptococcus neoformans is the major opportunistic pathogen of cryptococcosis. Rapid diagnosis of C. neoformans and other opportunistic Cryptococcus pathogens required to meet clinical need for immediate treatment. Historically, negative staining with India ink has been used identifyCryptococcus. Another method...
Abstract Background To investigate the morphological changes in adjacent vertebrae patients with congenital scoliosis caused by hemivertebra treated posterior resection unilateral short segment fixation. Methods A retrospective cohort study was conducted. From 2000 to 2023, 26 pediatric a single were included our institution. They and short-segment The preoperative, postoperative, final follow-up imaging parameters measured separately, such as main curve Cobb angle, correction rate, height...
Abstract A 50-year-old man experienced cough and bloody sputum for 1 month. CT detected a mass in the right lung. Staging 18 F-FDG PET/CT revealed multiple hypermetabolic lesions lung, mediastinum, liver, bones. Further physical examination black patches skin covering most parts of body, which presented at his birth were growing very slowly, consistent with giant congenital melanocytic nevus. Pathology after biopsy lung demonstrated metastatic melanoma.
Objective To differential the biologic characteristics and multiple differentiation potential of mesenchymal stem cells in nucleus pulposus (NP-MSC) scoliosis patient with degenerative interverthral disc.Methods The human pulposus-mesenchymal were isolated cultured enzyme digestion from 2 patients intervertbral disc separately.Cellular proliferation was detected MTT assay trypan blue.The immunophenotype expression NP-MSC by flow cytometry group.The ability assessed respectively using...
Objective To explore the feasibility and clinical curative effect of staging surgery for pediatric complicated congenital scoliosis. Methods A retrospective study was made 2 cases scoliosis had received from July 2006 to January 2013. The pre-operative postoperative parameters such as coronal sagittal balance, Cobb angle, shoulder balance were measured evaluate therapeutic effect. Results Case A been improved its angle 78° 40° decreased height difference scapulas 6 cm in first...