A5059709728- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Cognitive Functions and Memory
- EEG and Brain-Computer Interfaces
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Cognitive Abilities and Testing
- Psychiatric care and mental health services
- Advanced Memory and Neural Computing
- Mind wandering and attention
- Neuroscience and Neural Engineering
- Human-Automation Interaction and Safety
- Attention Deficit Hyperactivity Disorder
- Hemispheric Asymmetry in Neuroscience
- Neurological Disorders and Treatments
University of Bern
2017-2025
Universitäre Psychiatrische Dienste Bern
2019-2024
University Hospital of Bern
2017-2021
University of Freiburg
2013-2018
University Medical Center Freiburg
2013-2017
Bernstein Center for Computational Neuroscience Freiburg
2014-2017
University of Bamberg
2013
Old Dominion University
2001
Virginia Tech
1999
Städtisches Klinikum Karlsruhe
1994
Abstract Background Individuals with subjective memory impairment (SMI) report worsening of without in cognitive tests. Despite normal performance, they may be at higher risk decline compared individuals SMI. Methods We used a discriminative function (a support vector machine) trained on an independent data set 226 healthy control subjects and 191 patients probable Alzheimer's disease (AD) dementia to characterize the baseline gray matter patterns 24 SMI 53 subjects. tested for associations...
Several studies have demonstrated that fully automated pattern recognition methods applied to structural magnetic resonance imaging (MRI) aid in the diagnosis of dementia, but these conclusions are based on highly preselected samples significantly differ from seen a dementia clinic.At single clinic, we evaluated ability linear support 1 Some data used preparation this article were obtained Alzheimer's Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu).
Associative memory is one of the first cognitive functions negatively affected by healthy and pathological aging processes. Non-invasive brain stimulation (NIBS) techniques are easily administrable tools to support memory. However, optimal parameters inducing a reliable positive effect on older adult's performance remain mostly unclear. In our randomized, double-blind, cross-over study, 28 adults (16 females; 71.18 + 6.42 years age) received anodal transcranial direct (tDCS), alternating...
To investigate the efficacy of transcranial direct (tDCS) or alternating current stimulation (tACS) in boosting cognitive training efficiency healthy older adults. We further explored whether such improvements depend on general performance age. In this randomized, sham-controlled study, 59 elderly participants (mean age 71.7) were assigned to receive computer-based (10 sessions, 50 min, twice weekly) combined with tDCS (2 mA), tACS (5 Hz), sham over left dorsolateral prefrontal cortex (20...
Abstract Structural grey and white matter changes precede the manifestation of clinical signs Huntington’s disease by many years. Conversion to clinically manifest therefore likely reflects not merely atrophy but a more widespread breakdown brain function. Here, we investigated structure–function relationship close after onset, in important regional hubs, particularly caudate nucleus putamen, which are central maintaining normal motor behaviour. In two independent cohorts patients with...
The experience of pain and disgust share many similarities, given that both are aversive experiences resulting from bodily threat leading to defensive reactions. aim the present study was investigate whether facial expressions distinct enough encode specific quality or they just similar negative valence arousal level states. In sixty participants were induced by heat stimuli pictures, respectively. Facial responses (Facial Action Coding System) as well subjective assessed. Our main findings...
Abstract Objectives The age-prospective memory paradox states that younger adults perform better than older in laboratory tasks, while the opposite has been observed for naturalistic tasks. These terms insufficiently characterise tasks and task settings. We therefore revisited using a newly developed taxonomy to understand how characteristics or settings contribute age-related differences performance. Methods conducted meta-analysis of 138 studies, classifying prospective according our...
Although episodic memory impairment is usually the earliest sign of Alzheimer's disease (AD), there are up to 15% patients presenting with early in non-memory cognitive functions (i.e., atypical AD). Stratifying AD may aid clinical trials. Previous studies divided by profile, focusing on cross-sectional analyses without testing stability clusters over time. We used principal component analysis followed cluster 127 based 24 scores at 0, 6, 12, and months follow-up. investigated definition...
The left dorsolateral prefrontal cortex (DLPFC) is involved in encoding and retrieval of episodic memories, thus, frequently targeted non-invasive brain stimulation paradigms, aiming for its functional modulation. Anodal transcranial direct current (tDCS), that boosts neuronal excitability stimulated cortical areas, has been found to increase cognitive skills differentially, depending on the initial performance. We hypothesize benefit tDCS verbal memory can be extrapolated from participants'...
Compensation implies the recruitment of additional neuronal resources to prevent detrimental effect age-related decline on cognition. Recently suggested statistical models comprise behavioral performance, brain activation, and measures related aging- or disease-specific pathological burden characterize compensation. Higher chronological age as well APOE ε4 allele are risk factors for Alzheimer's disease. A more biological approach aging compared with is gap estimation (BrainAGE), taking into...
Acetylcholine is critically involved in modulating learning and memory function, which both decline neurodegeneration.It remains unclear to what extent structural functional changes the cholinergic system contribute episodic dysfunction mild cognitive impairment (MCI), addition hippocampal degeneration.A better understanding critical, given that main target of current symptomatic treatment moderate Alzheimer's disease.We simultaneously assessed integrity 20 patients with MCI matched healthy...
Abstract Background Several fMRI studies found hyperactivity in the hippocampus during pattern separation tasks patients with Mild Cognitive Impairment (MCI; a prodromal stage of Alzheimer’s disease). This was associated memory deficits, subsequent cognitive decline, and faster clinical progression. A reduction hippocampal an antiepileptic drug improved performance. Pharmacological interventions, however, entail risk side effects. An alternative approach may be real-time neurofeedback, which...
Abstract We assessed the structure–function relationship of human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure central signal transmission. Healthy volunteers (n = 36) patients mild cognitive impairment (MCI, n 20) underwent median nerve SAI 3T MRI to determine volume basal forebrain thalamus. Patients MCI had smaller ( p < 0.001) or thalamus volumes than healthy...
Abstract Background Alzheimer’s disease (AD) is a major public health issue. Cognitive interventions such as computerized cognitive trainings (CCT) are effective in attenuating decline AD. However, those at risk of dementia related to AD, results heterogeneous. Efficacy and feasibility CCT needs be explored depth. Moreover, underlying mechanisms effects on the three domains typically affected by AD (episodic memory, semantic memory spatial abilities) remain poorly understood. Methods In this...
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination which regions contribute to normal functioning despite accelerated neuronal loss. Besides the recruitment additional regions, a reorganisation and shift relevance between normally engaged are suggested key mechanism. Thus, network analysis methods seem critical for investigation changes directed causal interactions such candidate regions. To identify core compensatory fifteen patients...
LTP-like plasticity measured by visual evoked potentials (VEP) can be induced in the intact human brain presenting checkerboard reversals. Also associated with plasticity, around two third of participants respond to transcranial magnetic stimulation a paired-associate (PAS) protocol potentiation their motor potentials. processes are also required for verbal and learning tasks. We compared effect sizes, responder rates intercorrelations as well potential influence attention between these four...
Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to onset, which may reveal important mechanistic insights into brain function, structure organization general. While regional atrophy present at early stages HD, it still unclear if both hemispheres are equally affected by neurodegeneration how extent...