A5006147350- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
- Muscle activation and electromyography studies
- Vestibular and auditory disorders
- Infant Health and Development
- Nicotinic Acetylcholine Receptors Study
- Neonatal skin health care
- Intraoperative Neuromonitoring and Anesthetic Effects
- Acute Ischemic Stroke Management
- Biomedical and Chemical Research
- Balance, Gait, and Falls Prevention
- Infrared Thermography in Medicine
- Healthcare Decision-Making and Restraints
- Cancer-related cognitive impairment studies
- Cognitive Functions and Memory
University of Bern
2024-2025
Sensors (United States)
2024
University of Freiburg
2016-2021
University Medical Center Freiburg
2014-2019
Bernstein Center for Computational Neuroscience Freiburg
2018
Brain (Germany)
2015
Paired associative stimulation (PAS) is a widely used transcranial magnetic (TMS) paradigm to non-invasively induce synaptic plasticity in the human brain vivo. Altered PAS-induced has been demonstrated for several diseases. However, researchers are faced with high inter- and intra-subject variability of PAS response. Here, we pooled original data from nine studies three centers analyzed combined dataset 190 healthy subjects regard age dependency, role parameters effect different statistical...
Sensor-based surveillance technology (SST) is increasingly employed in the care of people with dementia (PwD) hospitals, nursing homes, and home care. With improved functionality availability SST, there will likely be a growing utilization clinical settings. In context staff shortage, expected resource-efficient safety benefits are attractive but must critically balanced against concerns that basic ethical principles violated. this discussion paper, we provide brief overview frequently used...
Objective. Brain–machine interfaces (BMI) are an emerging therapeutic option that can allow paralyzed patients to gain control over assistive technology devices (ATDs). BMI approaches be broadly classified into invasive (based on intracranially implanted electrodes) and noninvasive skin electrodes or extracorporeal sensors). Invasive BMIs have a favorable signal-to-noise ratio, thus for the extraction of more information than BMIs, but they also associated with risks related neurosurgical...
Compensation implies the recruitment of additional neuronal resources to prevent detrimental effect age-related decline on cognition. Recently suggested statistical models comprise behavioral performance, brain activation, and measures related aging- or disease-specific pathological burden characterize compensation. Higher chronological age as well APOE ε4 allele are risk factors for Alzheimer's disease. A more biological approach aging compared with is gap estimation (BrainAGE), taking into...
Acetylcholine is critically involved in modulating learning and memory function, which both decline neurodegeneration.It remains unclear to what extent structural functional changes the cholinergic system contribute episodic dysfunction mild cognitive impairment (MCI), addition hippocampal degeneration.A better understanding critical, given that main target of current symptomatic treatment moderate Alzheimer's disease.We simultaneously assessed integrity 20 patients with MCI matched healthy...
LTP-like plasticity measured by visual evoked potentials (VEP) can be induced in the intact human brain presenting checkerboard reversals. Also associated with plasticity, around two third of participants respond to transcranial magnetic stimulation a paired-associate (PAS) protocol potentiation their motor potentials. processes are also required for verbal and learning tasks. We compared effect sizes, responder rates intercorrelations as well potential influence attention between these four...
Transcranial magnetic stimulation (TMS) is a well-established tool in probing cortical plasticity vivo. Changes corticomotor excitability can be induced using paired associative (PAS) protocol, which TMS over the primary motor cortex conditioned with an electrical peripheral nerve of contralateral hand. PAS inter-stimulus interval 25 ms induces long-term potentiation (LTP)-like effects excitability. However, response to protocol tends vary substantially across individuals. In this study, we...
Abstract We assessed the structure–function relationship of human cholinergic system and hypothesized that structural measures are associated with short-latency sensory afferent inhibition (SAI), an electrophysiological measure central signal transmission. Healthy volunteers (n = 36) patients mild cognitive impairment (MCI, n 20) underwent median nerve SAI 3T MRI to determine volume basal forebrain thalamus. Patients MCI had smaller ( p < 0.001) or thalamus volumes than healthy...
Gait abnormalities in older adults are linked to increased risks of falls, institutionalization, and mortality, necessitating accurate frequent gait assessments beyond traditional clinical settings. Current methods, such as pressure-sensitive walkways, often lack the continuous natural environment monitoring needed understand an individual’s fully during their daily activities. To address this gap, we present a Lidar-based method capable unobtrusively continuously tracking human leg...
The identification of pathological atrophy in MRI scans requires specialized training, which is scarce outside dedicated centers. We sought to investigate the clinical usefulness computer-generated representations local grey matter (GM) loss or increased volume cerebral fluids (CSF) as normalized deviations (z-scores) from healthy aging either aid human visual readings directly detect atrophy. Two experienced neuroradiologists rated 30 patients with Alzheimer's disease (AD), frontotemporal...
Long-term potentiation (LTP) is a key element of synaptic plasticity. At the macroscopic level, similar effects can be induced in human brain using repetitive stimulation with identical stimuli. High-frequency (HFS) increase neuronal responses whereas low-frequency may produce opposite effect. Optimal frequencies and characteristics for inducing stimulus-specific response modification (SRM) differ substantially from those applied to tissue slices but have been explored recent studies. In...
Huntington's disease (HD) is a progressive neurodegenerative disorder that can be diagnosed with certainty decades before symptom onset. Studies using structural MRI have identified grey matter (GM) loss predominantly in the striatum, but also involving various cortical areas. So far, voxel-based morphometric studies examined each brain region isolation and are thus unable to assess changes interrelation of regions. Here, we covariance GM volumes pre-specified motor, working memory,...
Huntington's disease (HD) is a genetically caused neurodegenerative disorder characterized by heterogeneous motor, psychiatric, and cognitive symptoms. Although motor symptoms may be the most prominent presentation, such as memory deficits executive dysfunction typically co-occur. We used functional magnetic resonance imaging (fMRI) task-fMRI based dynamic causal modeling (DCM) to evaluate HD-related changes in neural network underlying working (WM). Sixty-four pre-symptomatic HD gene...
In mild cognitive impairment (MCI), small benefits from training were observed for memory functions but there appears to be great variability in the response treatment. Our study aimed improve characterization and selection of those participants who will benefit intervention. We evaluated predictive value disease-specific biological factors outcome after MCI (n = 25) also considered motivation participants. compared results intervention group with two independent control groups patients...
Objective: Electric fields (EF) of approx. 0.2 V/m have been shown to be sufficiently strong both modulate neuronal activity in the cerebral cortex and measurable effects on cognitive performance. We hypothesized that EF caused by electrical extracranial muscles during natural chewing may reach similar strength hence might act as an endogenous modality brain stimulation. Here, we present first steps toward validating this hypothesis. Methods: Using a realistic volume conductor head model...
Technologie de capteurs dans les chambres des patientsPénurie personnel qualifié Grâce à l' enregistrement continu besoins patientes et patients, le soignant a une vision claire ce qui se passe service.Les données cliniques objectives générées par systèmes facilitent la définition priorités optimisent quotidien unités soins.
Alzheimer's disease is a neurodegenerative disorder that involves degeneration of the cholinergic system in basal forebrain (e.g. Grothe et al., 2010; Grothe, Heinsen, & Teipel, 2012; Kása, Rakonczay, Gulya, 1997). Transcranial magnetic stimulation (TMS) protocols, like short latency afferent inhibition (SAI) motor cortex, can serve as useful tool to depict degeneration, SAI significantly reduced AD (Di Lazzaro 2002) well patients with amnestic MCI (Nardone 2012), which are at higher risk...
Neocortical LTP-like plasticity measured by transcranial magnetic stimulation (TMS) using a paired associative (PAS) protocol was found to be significantly reduced in patients with Alzheimer's Disease (AD) (Battaglia et al., 2007). Episodic memory, usually assessed via verbal learning tasks, is the most common early cognitive sign of AD and less pronounced mild impairment (MCI). So far, very little research has focused on PAS subjects MCI. abilities are likely associated each other, as both...