A5016496358- Vitamin D Research Studies
- Neonatal Respiratory Health Research
- Biosimilars and Bioanalytical Methods
- RNA regulation and disease
- Hair Growth and Disorders
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Immune responses and vaccinations
- Rheumatoid Arthritis Research and Therapies
- Dermatology and Skin Diseases
- Respiratory Support and Mechanisms
- Nanoplatforms for cancer theranostics
- Erythrocyte Function and Pathophysiology
- Graphene and Nanomaterials Applications
Versus Arthritis
2024
University of Glasgow
2021-2024
University of the West of Scotland
2018-2021
Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to reinstate tolerance RA. Using single-cell and spatial transcriptomics of ST biopsies, as well co-culture systems, we identified condition- niche-specific DC clusters with distinct functions. Healthy contained tolerogenic AXL
In injury or infection, monocytes migrate into the affected tissues from circulation and differentiate macrophages which are subsequently involved in inflammatory responses. Macrophage differentiation activation have been studied response to multiple chemokines cytokines. However, mechanical, physical stimuli can also influence macrophage differentiation, activation, cytokine production, phagocytic activity.In this study THP-1 was assessed upon stimulation with 1,25-dihydroxyvitamin D3 1,000...
Summary Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to re-instate tolerance RA. With single-cell and spatial-transcriptomics of biopsies, validated by micro co-culture systems, we identified condition niche-specific myeloid DC clusters with distinct differentiation trajectories functions. Healthy synovium contains a unique tolerogenic AXL pos DC2 cluster the...
Abstract Factors governing the coagulopathy and pneumonitis associated with severe viral infections remain unresolved. We previously found that expression of protein S (PROS1) is increased in lung epithelium patients mild COVID-19 as compared to COVID-19. hypothesised PROS1 may exert a local effect protects upper airway against inflammation by modulating epithelial myeloid cell responses. To test this, vitro air-interface cultures, seeded from primary healthy human cells, were infected...