A5101426663- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Flavonoids in Medical Research
- Traditional Chinese Medicine Analysis
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- Air Quality and Health Impacts
- Neurofibromatosis and Schwannoma Cases
- Antioxidant Activity and Oxidative Stress
- Lung Cancer Research Studies
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Exercise and Physiological Responses
- RNA modifications and cancer
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Biological Activities
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Microbial Metabolism and Applications
- Circadian rhythm and melatonin
- Cholangiocarcinoma and Gallbladder Cancer Studies
Qingdao University
2020-2023
Affiliated Hospital of Qingdao University
2020-2023
Guiyang Medical University
2023
Ocean University of China
2020
Qingdao Eighth People's Hospital
2020
University of California, San Francisco
2017
Wuhan University
2014
Huazhong University of Science and Technology
2008-2009
Shaanxi Research Association for Women and Family
2004
In recent years, the influence of environmental factors on organismal aging has garnered increasing attention. Studies have shown that sleep deprivation and pollutants could accelerate emergence multiple phenotypes. addition, studies chronic exposure to sodium arsenite (iAs) induces skeletal muscle atrophy inhibition melatonin secretion in rats. This study aimed reveal synergistic effect aging, including reduced limb grip strength mass, along with serum levels (MT) cortisol (COR) C57BL/6J...
Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit patients with sensitive EGFR mutations and significantly prolong survival. However, 20–30% of demonstrate primary resistance to EGFR-TKIs, which leads the failure EGFR-TKI treatment. The mechanisms require further study. Methods sequencing was used detection genomic alterations among in our center. Regular cell culture transfection plasmids were establish lines over-expressing MDM2 vector control. We MTT...
Background: Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related death. Although novel treatment currently achieves a better response, majority HCC patients develop resistance and cannot benefit. Hence, biomarkers for guiding therapy predicting prognosis are needed. Methods: Tissue microarrays 206 were used, ARID1A expression was determined by immunohistochemistry. Databases used verification expansion our results. The “rms” package R software construction nomogram....
Abstract Background The prognosis of lung cancer was found to be associated with a series biomarkers related the tumor immune microenvironment (TIME), which can modulate biological behaviors and consequent outcomes cancer. Therefore, establishing prognostic model based on TIME for patients, especially young patients adenocarcinoma (LUAD), is urgently needed. Methods In all, 809 from TCGA database 71 LUAD in our center were involved this study. Univariate multivariate analysis clinical...
Abstract Arsenic is a well‐known environmental toxicant and emerging evidence suggests that arsenic exposure has potential skeletal muscle toxicity; however, the underlying mechanism not yet been clarified. The aim of this study was to investigate correlation among adverse effects subchronic chronic on as well specific myokines secretion angiotensin II (AngII)–melatonin (MT) axis in rats. Four‐week‐old rats were exposed arsenite (iAs) drinking water at relevant concentration 10 ppm for 3 or...
Epidermal growth factor receptor (EGFR) mutation‐positive non‐small cell lung cancer (NSCLC) patients benefit from EGFR tyrosine kinase inhibitors (TKIs), while some demonstrate a resistance to EGFR‐TKIs. In the case reported here, NSCLC patient harboring an ‐sensitive mutation and YES1 amplification was treated with afatinib as first‐line therapy, but found have progressive disease four weeks later. During subsequent chemotherapy, this patient's progressed rapidly. Mechanisms of primary...
<div>Abstract<p>The Wnt/β-catenin pathway is among the most frequently altered signaling networks in human cancers. Despite decades of preclinical and clinical research, efficient therapeutic targeting has been elusive. RNA interference (RNAi) technology silences genes at mRNA level therefore can be applied to previously undruggable targets. Lipid nanoparticles (LNP) represent an elegant solution for delivery RNAi-triggering oligonucleotides disease-relevant tissues, but have...
<div>Abstract<p>The Wnt/β-catenin pathway is among the most frequently altered signaling networks in human cancers. Despite decades of preclinical and clinical research, efficient therapeutic targeting has been elusive. RNA interference (RNAi) technology silences genes at mRNA level therefore can be applied to previously undruggable targets. Lipid nanoparticles (LNP) represent an elegant solution for delivery RNAi-triggering oligonucleotides disease-relevant tissues, but have...
Abstract Background and Significance: Non-alcoholic fatty liver disease (NAFLD) is a major risk factor for the development of hepatocellular carcinoma (HCC). Even with successful surgical removal, presence NAFLD associated an increased recurrence HCC. Despite apparent association between HCC, mechanistic pathways that link both disorders are essentially unknown therapeutic agents lacking. MicroRNAs (miRNAs) play critical roles in cancer metabolic disorders, present tremendous potential....
Abstract Background Lung cancer has ranked first in China recent years, and TIME-related molecules may serve as biomarkers for the prognosis of lung cancer. Nomograms are widely used tools evaluation malignancies. We performed this study to construct nomograms based on TIME predicting Methods Univariate multivariate analyses were estimate prognosis. variables basic clinical characteristics included nomograms. Discrimination calibration internal validation Patients our center TCGA database...