A5034118011- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- Liver Diseases and Immunity
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Intraocular Surgery and Lenses
- Cerebrovascular and Carotid Artery Diseases
- Iron Metabolism and Disorders
- Retinal and Macular Surgery
- Angiogenesis and VEGF in Cancer
- Pancreatitis Pathology and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Chemokine receptors and signaling
- Health and Lifestyle Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Lysosomal Storage Disorders Research
- Cardiovascular Disease and Adiposity
Paracelsus Medical University
2015-2025
Cedars-Sinai Medical Center
2020-2024
University of Miami
2020-2023
University of Salzburg
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Ospedale Maggiore
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Duke Medical Center
2021
Dell Children's Medical Center of Central Texas
2019
Pädagogische Hochschule Salzburg
2019
Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity; however, 5-8% of lean subjects also have evidence NAFLD. We aimed investigate clinical, genetic, metabolic and lifestyle characteristics in Caucasian with NAFLD.Data from 187 allocated one the three groups according body mass index (BMI) hepatic steatosis on ultrasound were obtained: healthy (BMI≤25 kg/m2, no steatosis, N=71), NAFLD N=55), obese (BMI≥30 steatosis; N=61). All received a detailed clinical laboratory...
Objective Homozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing cirrhosis, whereas relevance of heterozygous carriage remains unclear. Hence, we evaluated impact two most relevant AAT variants (‘Pi*Z’ and ‘Pi*S’), present in up to 10% Caucasians, on subjects with non-alcoholic fatty liver disease (NAFLD) or alcohol misuse. Design We analysed multicentric case–control cohorts consisting 1184 people biopsy-proven NAFLD 2462 chronic misuse, both comprising cases...
A small proportion of lean patients develop non-alcoholic fatty liver disease (NAFLD). We aimed to report the histological picture NAFLD in comparison overweight and obese patients. Biopsy clinical data from 466 diagnosed with were stratified groups according body mass index (BMI): (BMI ≤ 25.0 kg/m², n confirmed be appropriate = 74), > 30.0 242) 150). Lean had a higher rate lobular inflammation compared (12/74; 16.2% vs. 19/242; 7.9%; p 0.011) but similar (25/150; 16.7%). Ballooning was...
<h3>Background</h3> To analyse the 24-month outcomes of intravitreal ranibizumab injections for choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD). <h3>Methods</h3> The authors reviewed charts all consecutive eyes with CNV AMD, who underwent one injection (followed by a pro re nata (1+PRN) decision retreat or not retreat) at least 24 months before. Best-corrected visual acuity (BCVA) changes and central thickness (CMT) were retrospectively assessed, from...
Vascular endothelial growth factor (VEGF) has become a major target in cancer treatment as it promotes tumor angiogenesis. Therapy with anti-VEGF antibody bevacizumab reportedly induces high levels of circulating VEGF which may potentially contribute to resistance. Based on animal or computational models, mechanisms induction by have been proposed but not verified the clinical setting. Hence, we evaluated sixty patients colorectal metastases for changes plasma during neoadjuvant/conversion...
Elevated serum ferritin has been linked to type 2 diabetes (T2D) and adverse health outcomes in subjects with the Metabolic Syndrome (MetS). As mechanisms underlying negative impact of excess iron have so far remained elusive, we aimed identify potential links between homeostasis metabolic pathways.In a cross-sectional study, data were obtained from 163 patients, allocated one three groups: (1) lean, healthy controls (n = 53), (2) MetS without hyperferritinemia 54) (3) 56). An additional...
Although non-alcoholic fatty liver disease (NAFLD) is linked to obesity, a proportion of lean subjects also have NAFLD with potentially distinct clinical features. We studied the outcome subjects.299 consecutive patients (215 male, 84 female, 49.5 ± 13.5years) biopsy-proven and follow-up 8.4 years (±4.1; range: 0.9-18.0) were stratified by body mass index (BMI) at time biopsy: (BMI ≤25.0 kg/m, n=38), overweight 25.0-29.9 kg/m2, n=165), obese ≥30.0 n=93). A control group 1,013 (547 52.4 5.8)...
Permanent genital hair removal is required before gender-affirming vaginoplasty to prevent hair-related complications. No previous studies have directly compared the relative efficacy, costs, and patient experiences with laser (LHR) vs electrolysis treatments. Food Drug Administration (FDA) oversight of medical devices poorly understood commonly misrepresented, adversely affecting care.This study compares treatment outcomes LHR for investigates FDA regulation devices.Penile-inversion...
BACKGROUND. Alterations in circulating metabolites have been described obese metabolic dysfunction-associated steatotic liver disease (MASLD), but data on lean MASLD are lacking. We investigated serum metabolites, including microbial bile acids (BAs) and short-chain fatty (SCFAs), their association with MASLD.
Approximately one-third of patients with non-alcoholic fatty liver disease (NAFLD) show signs mild-to-moderate iron overload. The impact histological deposition on the clinical course NAFLD has not been established.For this retrospective study, 299 consecutive biopsy-proven and a mean follow-up 8.4 (±4.1; range: 0.3-18.0) years were allocated to one four groups according presence hepatic in reticuloendothelial system (RES) and/or hepatocytes (HC): 156 subjects (52%) showed no stainable...
Anti-mitochondrial antibodies (AMA) are closely linked to primary biliary cholangitis (PBC). The prevalence of AMA in the general population is low, and positivity may precede PBC. We aimed determine natural history subjects with positive AMA.In total, 302 patients were tested AMA-positive over a ten-year period. Of these, immunoblotting confirmed specific 184 (29 male, 155 female, age 59.6 ± 14.1 years). These invited our liver outpatient clinic for clinical biochemical re-evaluation....
We have previously reported that intermediate monocytes (CD14(++)/CD16(+)) were increased in colorectal cancer (CRC) patients, while the subset of pro-angiogenic TIE2-expressing (TEMs) was not significantly elevated. This study designed to evaluate changes frequency and function TEMs during chemotherapy anti-angiogenic treatment their relation response. Monocyte populations determined by flow cytometry 60 metastasized CRC (mCRC) patients who received neoadjuvant with or without bevacizumab....
Abstract Introduction In the United States, 1.4–1.65 million people identify as transgender, many of whom will seek genital gender-affirming surgery (GAS). The number surgeons, geographic proximity thereof, and exclusionary insurance policies has limited patient access to GAS. Aim To assess accessibility both feminizing masculinizing GAS (vaginoplasty, metoidioplasty, phalloplasty) by identifying location health insurance, or payment forms accepted. Methods Between February April 2018,...
Single nucleotide polymorphisms (SNPs), including PNPLA3 rs738409 and SERPINA1 rs17580, have been identified as risk modifiers in the progression fatty liver disease (alcoholic (ALD) or non-alcoholic (NAFLD)). While has studied various settings, value of both SNPs so far not addressed a real-world cohort subjects referred for diagnostic work-up disease. Thus, severity was assessed 1257 consecutive patients with suspected ALD NAFLD at time referral to tertiary center. Advanced chronic (ACLD)...
Liver biopsy (LB) is performed if non-invasive work-up of liver disease inconclusive. The examination tissue occasionally reveals normal histology. Long-term follow-up such patients has not been performed.We identified a total 70 subjects from our LB database with elevated tests and histology after mean 90.5 ± 52.3 (range 15-216) months conducted reassessment medical history, physical examination, laboratory testing, ultrasound, transient elastography indicated.At 15 (7 females (f)/8 males...
PurposeTo evaluate the use of infracyanine green (IFCG) staining in idiopathic epiretinal membrane (ERM) surgery. MethodsA retrospective comparative study 63 consecutive eyes with ERM operated on internal limiting (ILM) peeling using or not filtered IFCG diluted (5:1) glucose 5%. Main outcome measures were best-corrected visual acuity, central field perimetry, fluorescein angiography blue light fundus photograph, optical coherence tomography (OCT), and seven multifocal electroretinogram...