A5102748291- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Catalytic C–H Functionalization Methods
- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Biomedical Ethics and Regulation
- Cardiac Imaging and Diagnostics
- Methemoglobinemia and Tumor Lysis Syndrome
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Liver Disease and Transplantation
- Connective Tissue Growth Factor Research
- Cell death mechanisms and regulation
- Synthesis and Catalytic Reactions
- Cardiovascular Function and Risk Factors
- Diamond and Carbon-based Materials Research
- Fusion materials and technologies
- Radiation Dose and Imaging
- Bioactive Compounds and Antitumor Agents
- Advanced MRI Techniques and Applications
- Radical Photochemical Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiomyopathy and Myosin Studies
- Calcium Carbonate Crystallization and Inhibition
- Marine Sponges and Natural Products
Chiba University
2024-2025
Kanazawa Medical University
2017-2024
Keiju Medical Center
2020
National Institute of Technology, Toba College
2017
Osaka University
2001-2011
Nagoya University
1995-2007
Injury of endothelial cells has been assumed to be an initial trigger the development atherosclerosis. In this study, we investigated molecular mechanisms cell death induced by hypoxia, which leads oxidative stress. To study relation between hypoxia-induced and activation nuclear factor-κB (NF-κB) in a hypoxic state, evaluated effect 2 antioxidant drugs, probucol pyrrolidine dithiocarbamate (PDTC), on human apoptosis. Although treatment aortic resulted significant decrease number increase...
Newman-Kwart rearrangement (NKR) is a useful method for synthesizing S-aryl thiocarbamates from O-aryl thiocarbamates. Harsh temperature conditions are required, however, leading to substrate degradation and side reactions. Moreover, reactions using heteroaromatic substrates quite rare. Herein, we report Bi(OTf)3-catalyzed NKR under ambient conditions. The reaction extended not only aza-arene but also thiophene substrates.
Pseudoindoxyl is a partial skeleton found in various natural products. Its light-absorption properties make it useful for the design of functional molecules. However, versatile synthesis methods have not yet been reported. In this report, we present synthetic method pseudoindoxyls using direct S0 → Tn transition under visible light irradiation. We also discuss application as photocatalysts.
Arteriovenous fistula puncture pain is a serious problem for patients undergoing dialysis and good indication topical anesthetics. No previous study has compared lidocaine/prilocaine cream (EMLA) with lidocaine tape relief during arteriovenous in maintenance hemodialysis. To this end, we conducted multicenter randomized crossover including 66 (mean age, 65.8 years; males, 57.6%) hemodialysis thrice/week. Subjects were assigned to Sequence EL (EMLA administration followed by lidocaine, 1-week...
The total synthesis of dragmacidins G and H was achieved for the first time by employing nucleophilic aromatic substitution site-selective cross-coupling reactions using appropriately functionalized pyrazines as substrates. evaluation antibacterial activities dragmacidin G, H, synthetic analogues against Staphylococcus aureus efflux pump-deficient Salmonella Typhimurium revealed that presence a Br group on indole ring adjacent to sulfide unit important increasing activities.
Aim Conclusions regarding the best rituximab (RTX) dose to maintain remission and reduce immunosuppressant dependence in adult patients with steroid-dependent minimal change nephrotic syndrome (MCNS) are inconsistent. We report first low-dose (l 375 mg/m2 BSA) RTX therapy, administered once every 6 months. Materials methods In this retrospective single-arm cohort study, we investigated safety efficacy of therapy ultimately stop prednisolone (PSL) cyclosporine (CyA) treatment. 13 (8 men 5...
The estimated glomerular filtration rate (eGFR) at 1 year post-transplantation is a well-established predictor of long-term graft survival; however, its predictive accuracy needs improvement. We retrospectively analyzed data from 51 kidney transplant recipients Kanazawa Medical University Hospital (January 2001–February 2015). Cox regression was used to identify risk factors for death-censored loss and create nomogram predict survival 15 years post-transplantation. ultimately included in the...
Reduction of septal mass by inducing infarction using catheter techniques is a new therapy for hypertrophic obstructive cardiomyopathy (HOCM). We report case severe HOCM that was dramatically improved this non-surgical treatment. A 60-year-old woman with had suffered dyspnea (NYHA class III) syncopal attack despite medical Left heart catheterization showed resting pressure gradient across the left ventricular outflow tract 156 mmHg. Two proximal branches anterior descending coronary artery...
The slag produced as by-product in steel-making processes is utilized for various purpose due to its special qualities. Bacteria or other microorganisms generally form the biofilm. They are formed at interface between materials and water environment by action of bacteria. Biofilm can cause problems. Therefore, control biofilm formation needed. In this study, we focused on application marine environments carried out a research biofouling mortars mixed with iron/steel slags through immersion...
The recently introduced 320-detector row computed tomography (320-row CT) allows very fast volumetric acquisition of the entire heart. Because total amount contrast agent required for CT coronary angiography (CTCA) depends directly on time, 320-row CTCA would substantially reduce dose. objective this retrospective study was to evaluate feasibility volume reduction compared with 64-detector (64-row CTCA). We retrospectively reviewed consecutive 320- and 64-row data (16 eligible cases each;...
35歳女性. 結節性硬化症 (tuberous sclerosis: TSC) に合併した両腎の巨大腎血管筋脂肪腫 (angiomyolipoma: AML) による慢性腎不全のため, 33歳時より当科外来に通院していた. 激しい右側腹部痛を主訴に救急外来を受診. 急激な貧血進行および右腎AML内にCT高吸収域を認めたことからAML自然破裂による腫瘍内出血が疑われ, 右腎摘出術が施行された. 術後, AML内に合併したオンコサイト様乳頭状腎細胞癌 (oncocytic papillary renal cell carcinoma: OPRCC) が出血源であると病理診断された. 右腎摘出に伴い, 腎不全の進行を認め, 慢性維持血液透析導入となった. 本症例は, TSC腎病変としてAMLと特殊な組織型の腎細胞癌との共存を認めたまれな症例であり, TSC腎病変の管理を考えるうえでも示唆に富む症例であると考え, 報告する.
Abstract Background and Aims The impact of hepatitis C virus (HCV) infection on patient survival after renal transplantation was worse. Previously, we found that continuous HCV a significant independent risk factor for actuarial (especially at ≥20 years the transplant procedure) among Japanese allograft recipients. This study evaluates new direct acting antivirals (DAAs) outcomes in Method We studied 46 cases (28 males, 18 females; 37 living-donor cases, 9 deceased-donor cases; mean...