A5077296723- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Vascular Procedures and Complications
- Natural product bioactivities and synthesis
- Histone Deacetylase Inhibitors Research
- Sesquiterpenes and Asteraceae Studies
- Venous Thromboembolism Diagnosis and Management
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Central Venous Catheters and Hemodialysis
- Veterinary medicine and infectious diseases
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Bioactive Natural Diterpenoids Research
- Bacteriophages and microbial interactions
- Cancer therapeutics and mechanisms
Fujian Women and Children Hospital
2024
Fujian Medical University
2017-2021
Hunan Provincial People's Hospital
2016
Epidermal growth factor receptor (EGFR) overexpression is related to the increased aggressiveness, metastases, and poor prognosis in various cancers. In this study, we successfully constructed a new EGFR nanobody-based immunotoxin rE/CUS containing cucurmosin (CUS), The was expressed by prokaryotic system obtained yield of 5 mg protein per liter expression medium. percentage it's binding ability totumor cell lines A549, HepG2, SW116, which highly 55.6%, 79.6% 97.1%, respectively, but SW620...
One new ent ‐kaurane diterpenoid, 11 β ,16 α ‐dihydroxy‐ ‐kauran‐19‐oic acid ( 1 ), together with eight known analogues 2 – 9 were isolated from the aerial parts of Wedelia prostrata . acidic diterpenoids, kaurenoic 3 was converted to seven derivatives, 10 16 All compounds evaluated for their cytotoxic activity in vitro against human leukemia (K562), liver (HepG‐2), and stomach (SGC‐7901) cancer cell lines. Only four 13 , 15‐keto substitutions at C(19) position, exhibited notable activities...
Cutaneous melanoma (CM) is an aggressive form of skin cancer with limited treatment options for advanced stages. Prognostic markers that accurately predict patients' outcomes and guide therapeutic strategies are crucial improving management. SETD2 (SET Domain-Containing Protein 2), a histone methyltransferase involved in chromatin remodeling gene regulation, has recently emerged as tumor suppressor. Its dysfunction oncogenesis some cancers, but little known about its functions progression...
Objective To explore the reasons of abnormal decannulation in patients with malignant tumor undergoing chemotherapy during peripherally inserted central catheter (PICC) period. Methods A prospective study was conducted among 291 cancer who used PICC for Hunan Provincial People′s Hospital from January 2012 to June 2014. The occurrence complications period and were investigated collected. time follow-up one year. Results Among patients, there 72 cases (24.74%) 44 (15.12%)...
Abstract PRKDC is a key factor involved in the ligation step of non-homologous end joining pathway. Its dysfunction has proven to be biomarker for radiosensitivity cancer cells. Our previous study shown that mutations associated with tumor immune response. However, prognostic value at transcriptome levels and underlying mechanisms have not been clarified yet. In this study, we analyzed mRNA pan-cancer datasets examined its prediction prognosis, immunotherapy chemotherapeutic responses. We...