A5102733356- Helicobacter pylori-related gastroenterology studies
- Redox biology and oxidative stress
- Food Allergy and Anaphylaxis Research
- Food composition and properties
- Proteins in Food Systems
- Gastric Cancer Management and Outcomes
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Advanced Proteomics Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Digestive system and related health
- Phytoestrogen effects and research
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Inflammatory mediators and NSAID effects
- Receptor Mechanisms and Signaling
- GABA and Rice Research
- Pancreatic and Hepatic Oncology Research
- Amino Acid Enzymes and Metabolism
- Vasculitis and related conditions
- Polyamine Metabolism and Applications
- Diet, Metabolism, and Disease
- Protein Hydrolysis and Bioactive Peptides
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
National Agriculture and Food Research Organization
2009-2024
Okinawa Prefectural Chubu Hospital
2019-2024
Food Research Institute
2009-2023
Nippon Medical School
2011-2023
National Center for Global Health and Medicine
2016-2023
Osaka University
1994-2022
Oita University
2013-2021
Kyushu University
2021
Hannan University
2021
National Institute of Genetics
2019
Thioredoxins are 12-kDa proteins functional in the regulation of cellular processes throughout animal, plant, and microbial kingdoms. Growing evidence with seeds suggests that an h -type thioredoxin, reduced by NADPH via NADP-thioredoxin reductase, reduces disulfide bonds target thereby acts as a wakeup call germination. A better understanding role thioredoxin well other systems could be achieved if more were known about proteins. To this end, we have devised strategy for comprehensive...
Inorganic polyphosphate [poly(P)] levels in Escherichia coli were reduced to barely detectable concentrations by expression of the plasmid-borne gene for a potent yeast exopolyphosphatase [poly(P)ase]. As consequence, resistance H 2 O was greatly diminished, particularly katG (catalase HPI) mutants, implying major role other catalase, stationary-phase KatE (HPII), which is rpoS dependent. Resistance restored wild-type complementation with plasmids expressing ppk , PPK [the kinase that...
The effects of 1α-hydroxyvitamin D3[1α(OH)D3] and 1,25-dihydroxyvitamin D3[1,25(OH)2D3] on the incidence colon tumors induced by azoxymethane labeling index angiogenesis were investigated in Wistar rats. Rats received 10 weekly injections 7.4 mg/kg body weight i.p. 1α(OH)D3 1,25(OH)2D3 at lower higher doses every other day for 45 weeks. Prolonged administration both a dose significantly reduced week 45. However, or had little no effect histologic type cancers. Administration decreased index,...
It is proposed that non-steroidal anti-inflammatory drugs (NSAIDs) reduce colorectal tumorigenesis by inhibition of cyclooxygenase (COX). COX a key enzyme in the conversion arachidonic acid to prostaglandins and two isoforms have been characterized, COX-1 COX-2. Multiple studies shown COX-2 expressed at high levels tumours play role tumorigenesis. Recently it has reported selective inhibits colon cancer cell growth. In this study we investigated effect inhibitor (JTE-522) on haematogenous...
The wide prevalence of celiac disease and wheat allergy has led to a growing demand for gluten-free foods. Rice proteins do not possess the viscoelastic properties typically found in gluten, thus making rice flour unsuitable production yeast-leavened products. In present study, we that addition glutathione batter improves its gas-retaining properties. Glutathione was prevent formation disulfide-linked macromolecular protein barrier, which is reported confer resistance deformation baking...
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia carbohydrate overload, contributes to their pathogenesis. Fatty acid synthase (FASN), a key enzyme DNL, is upregulated in association with insulin resistance. However, the therapeutic potential targeting FASN hepatocytes for obesity-associated metabolic diseases unknown. Here, we show that deficiency differentially...
Telomerase activity is reported to be specific and very frequent in human malignancy. K-ras mutations are also frequently detected pancreatic cancer, but their specificity for cancer controversial. We examined the telomerase juice from patients with disease.Pancreatic was obtained endoscopically at endoscopic retrograde pancreatography 10 three chronic pancreatitis, a normal pancreas. The assayed by telomeric repeat amplification protocol. exon 1 codon 12 were two-step polymerase chain...
Immunoglobulin E (IgE)-mediated food allergies to wheat that develop after school age typically shows a type of wheat-dependent exercise-induced anaphylaxis (WDEIA). At present, avoidance products or postprandial rest ingesting is recommended for patients with WDEIA, depending on the severity allergy symptoms. ω5-Gliadin has been identified as major allergen in WDEIA. In addition, α/β-, γ-, and ω1,2-gliadins, high low molecular weight-glutenins, few water-soluble proteins have IgE-binding...
Our understanding of the neural mechanism human olfaction is still equivocal. Several recent reports document that functional magnetic resonance imaging (MRI) has a potential to visualize dynamic brain function in humans without invasion. In present study, we applied MRI with odor stimulation for purpose clarifying localization olfactory cortices human. We obtained significant increase cerebral blood flow piriform cortex, orbitofrontal and inferior medial frontal lobe, corresponding...
The effects of prolonged administration d-limonene, a monocyclic monoterpene, on sodium chloride-enhanced induction gastric carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine, the labeling and apoptotic indices, ornithine decarboxylase (ODC) activity cancers were investigated in Wistar rats. After 25 weeks carcinogen treatment, rats given chow pellets containing 10% chloride 1% limonene ad libitum. In week 52, incidence cancers, index ODC significantly higher was lower chlolide than...
The mobilization of storage proteins (glutelins) in germinating rice seeds was accompanied by an ordered sequential combination proteolysis and reduction disulfide groups. Mobilization followed application non-reducing/reducing two dimensional-PAGE after monobromobimane labeling the sulfhydryl groups intact seeds.
Abstract Hepatic gluconeogenesis during fasting results from gluconeogenic gene activation via the glucagon–cAMP–protein kinase A (PKA) pathway, a process whose dysregulation underlies hyperglycemia in diabetes. Such transcriptional requires epigenetic changes at promoters by mechanisms that have remained unclear. Here we show GCN5 functions both as histone acetyltransferase (HAT) to activate and an for co-activator PGC-1α inhibit fed state. During fasting, PKA phosphorylates manner...
Bread and cheese have been a popular combination since early times. Indeed, the history of bread dates back to 8000 BC that 7200 BC. However, new types breads cheeses are increasingly for several reasons, such as allergies, lifestyles, economy religion. The major challenge is food manufacturers offering products most which not welcomed by consumers. Therefore, recently, researchers placed importance on their relationships with consumers boost success products. This short review summarizes...
Previous studies have demonstrated that postprandial hyperglycemia attenuates brachial artery flow-mediated dilation (FMD) in prediabetic patients, diabetic and even normal subjects. We previously reported hyperinsulinemia also FMD. In the present study we evaluated relationship between different degrees of attenuation FMD induced by differences ingested carbohydrate content non-diabetic individuals. Thirty-seven healthy subjects with no family history diabetes were divided into 3 groups: a...
Accumulating evidence suggests that redox regulations play important roles in a broad spectrum of biological processes. Recently, Yano et al. developed disulfide proteome technique comprehensively visualizes change proteins. In this paper, using the proteome, we examined rice bran and identified fragments embryo-specific protein dienelactone hydrolase as putative targets thioredoxin. Also, monitoring endogenous recombinant effects thioredoxin on proteins supporting vivo observations propose...
Glycosylation plays crucial regulatory roles in various biological processes such as development, immunity, and neural functions. For example, α1,3-fucosylation, the addition of a fucose moiety abundant Drosophila cells, is essential for function, behavior. However, it remains largely unknown how neural-specific α1,3-fucosylation regulated. In present study, we searched genes involved glycosylation protein using RNAi library. We obtained 109 affecting that clustered into nine functional...