A5055052986- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Immune cells in cancer
- Advanced Sensor and Energy Harvesting Materials
- Wound Healing and Treatments
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Blood properties and coagulation
- 2D Materials and Applications
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Occupational exposure and asthma
- Alcohol Consumption and Health Effects
- MXene and MAX Phase Materials
- Monoclonal and Polyclonal Antibodies Research
- Diabetic Foot Ulcer Assessment and Management
- Systemic Lupus Erythematosus Research
University of Nebraska Medical Center
2022-2024
University of Nebraska at Omaha
2022
Saint Louis University
2016
UCLouvain Saint-Louis Brussels
2016
The objective of this study is to determine the associations protein-specific anti-malondialdehyde-acetaldehyde (MAA) antibodies with prevalent and incident rheumatoid arthritis-interstitial lung disease (RA-ILD).
Post-translational protein modifications with malondialdehyde-acetaldehyde (MAA) and citrulline (CIT) are implicated in the pathogenesis of rheumatoid arthritis (RA). Although precise mechanisms have not been elucidated, macrophage-fibroblast interactions proposed to play a central role development progression RA. The purpose our study was evaluate downstream effects macrophage released soluble mediators, following stimulation fibrinogen (FIB) modified antigens, on human fibroblast-like...
Abstract Objectives To determine whether an expanded antigen-specific ACPA profile predicts changes in disease activity patients with RA initiating biologics. Methods The study included participants from a prospective, non-randomized, observational cohort. For this sub-study, treatment groups of interest biologic-naïve anti-TNF, biologic-exposed non-TNF, and abatacept. ACPAs to 25 citrullinated peptides were measured using banked enrolment serum. Principal component analysis (PCA) was...
We demonstrate a scalable production of quality WS<sub>2</sub>/MoS<sub>2</sub> vertical and lateral heterostructures with controlled geometries employing bottom-up direct writing approach.
The objective of this study was to assess fibrinogen (FIB) co-modified with citrulline (CIT) and/or malondialdehyde-acetaldehyde (MAA) initiates macrophage-fibroblast interactions leading extracellular matrix (ECM) deposition that characterizes rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Macrophages (Mϕ) were stimulated native-FIB, FIB-CIT, FIB-MAA or FIB-MAA-CIT. Supernatants (SN) (Mϕ-SN [U-937-derived] MϕP-SN [PBMC-derived]) direct antigens co-incubated human...
Objective: Post-translational modifications of extracellular matrix proteins such as fibrinogen may lead to tolerance loss and have been implicated in rheumatoid arthritis (RA) pathogenesis. The purpose this study was determine whether (FIB) modified with citrulline (CIT), malondialdehyde-acetaldehyde (MAA) or both leads altered macrophage polarization, peptidyl arginine deiminase (PAD) expression, production citrullinated proteins.Methods: PMA-treated U-937 cells (M0 cells) were stimulated...