A5025336457- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Origins and Evolution of Life
- Fullerene Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Protein Structure and Dynamics
- Supramolecular Self-Assembly in Materials
- Photochromic and Fluorescence Chemistry
- Microbial Metabolic Engineering and Bioproduction
- Photoreceptor and optogenetics research
- Organic Electronics and Photovoltaics
- Photosynthetic Processes and Mechanisms
- Synthesis and Properties of Aromatic Compounds
- Bioinformatics and Genomic Networks
- Luminescence and Fluorescent Materials
- Lipid Membrane Structure and Behavior
- Gene Regulatory Network Analysis
- Carbohydrate Chemistry and Synthesis
- Evolution and Genetic Dynamics
- RNA and protein synthesis mechanisms
- Supramolecular Chemistry and Complexes
- Advanced Photocatalysis Techniques
- DNA and Nucleic Acid Chemistry
Universidad Autónoma de Madrid
2015-2024
IMDEA Nanoscience
2022
Institute for Advanced Medical Research
2018-2020
Institute of Advanced Chemistry of Catalonia
2019
Instituto de Investigaciones Químicas
2018
Madrid Institute for Advanced Studies
2015-2017
Radboud University Nijmegen
2008-2010
Universidad de Zaragoza
2008
Johannes Kepler University of Linz
2007
Friedrich-Alexander-Universität Erlangen-Nürnberg
2006
A novel ZnPc−C60 dyad (3), in which two photoactive units are brought together by a phenylenevinylene spacer has been synthesized. The synthetic strategy en route toward 3 involves Heck reaction to attach 4-vinylbenzaldehyde monoiodophthalocyanine precursor, followed standard cycloaddition of azomethine ylides (generated from the formylPc derivative and N-methylglycine) one double bonds C60. Electrochemical studies reveal that ZnPc is about 39 mV more difficult oxidize than corresponding...
We report herein the encapsulation of a water-soluble phthalocyanine (Pc) into virus-like particles (VLPs) two different sizes, depending on conditions. At neutral pH, cooperative encapsulation/templated assembly induces formation Pc stacks instead dimers, due to an increased confinement concentration. The Pc-containing VLPs may potentially be used as photosensitizer/vehicle systems for biomedical applications such photodynamic therapy.
Amino acid formation by hydride transfer from NADH without the need for enzymes connects prebiotic chemistry with metabolic pathways that presumably led to these biomolecules in first autotrophic protocells.
A novel donor−acceptor bisphthalocyanine (bis-Pc, 1) in which two different Pc units (Zn(II)-Pc and Ni(II)-Pc) are linked via vinylene spacers to the pseudopara positions of a central [2.2]paracyclophane moiety is described. The synthesis 1 achieved by successive Heck reactions pseudopara-divinyl[2.2]paracyclophane 9 with, sequentially, zinc(II)- nickel(II)-iodophthalocyanine (4 5, respectively). self-assembly ability 1, result complementary character its phthalocyanine units, has been...
Novel zinc phthalocyanine (ZnPc)/fullerene ligand (L) ensembles are assembled following simple biomimetic principles, which upon photoexcitation give rise to intra complex electron transfer quenching of the 1*ZnPc fluorescence.
In this highlight, recent studies related to the use of viral capsids and other protein cages as nanocontainers nanoreactors are discussed. The templating chemical reactions within these biological hollow scaffolds is an emerging area which has allowed synthesis inorganic materials with nanoscale dimensions. Encapsulation synthetic polymers, enzymes working capsids, solubilisation in organic solvents some examples research that currently being performed reviewed article.
Phthalocyanines (Pc) are non-natural organic dyes with wide and deep impact in materials science, based on their intense absorption at the near-infrared (NIR), long-lived fluorescence high singlet oxygen ((1)O2) quantum yields. However, Pcs tend to stack buffer solutions, losing ability generate oxygen, which limits scope of application. Furthermore, challenging organize crystalline structures. Protein cages, other hand, very promising biological building blocks that can be used different...
Significance Research on the chemical origin of life comprises one most exciting topics in contemporary science. Prebiotic chemistry provided evidence that precursors both nucleic acids and proteins might be formed prebiotic environment. Yet, studies nonenzymatic replication—a central mechanism driving evolution—focused largely each class these molecules separately. This paper reveals a successful attempt to replicate simple nucleopeptide chimeras. Most importantly, different mechanisms...
The use of a viral template has allowed the synthesis monodisperse Prussian blue nanoparticles with diameter 18 ± 1.7 nm and their organization into hexagonal patterns on mica hydrophilic carbon surfaces.
Abstract The family of subphthalocyanine (SubPc) macrocycles represents an interesting class nonplanar aromatic dyes with promising features for energy conversion and optoelectronics. use SubPcs in biomedical research is, on the contrary, clearly underexplored, despite their documented high fluorescence singlet oxygen quantum yields. Herein, first time it is shown that interaction these chromophores light can also be useful theranostic applications, which case comprise optical imaging...
Phthalocyanines (Pc) are dyes in widespread use materials science and nanotechnology, with numerous applications medicine, photonics, electronics energy conversion. With the aim to construct biohybrid materials, we here prepared analyzed structure of two Pc-loaded virus-like particles (VLP) diameters 20 28 nm (i.e., T = 1 3 icosahedral symmetries, respectively). Our cryo-electron microscopy (cryo-EM) studies show an unprecedented, very high level Pc molecule organization within both VLP. We...
In this article, we show the great potential of dendrimers for driving self-assembly biohybrid protein nanoparticles. Dendrimers are periodically branched macromolecules with a perfectly defined and monodisperse structure. Moreover, they allow possibility to incorporate functional units at predetermined sites, either their core, branches, or surface. On these bases, have designed synthesized negatively charged phthalocyanine (Pc) that behave as photosensitizers activation molecular oxygen...
The use of blends in which a mesogen induces mesomorphism into non-mesogenic compound has made possible the self-organization phthalocyanine--[60]fullerene (Pc-C60) dyads liquid crystals. Pc-C60 1, 2, or 3, two photoactive units are brought together by phenylenevinylene spacer, have been synthesized through Heck reaction that links 4-vinylbenzaldehyde to monoiodophthalocyanine precursor, followed standard cycloaddition azomethine ylides--generated from formylPc derivative and...
In this paper, we describe the controlled incorporation of two synthetic polymers with different structures in cowpea chlorotic mottle virus (CCMV) capsid. Poly(ethylene glycol) (PEG) chains have been attached to amine groups lysine residues on outer surface viral The functionalization CCMV PEG provoked a slow but irreversible dissociation into PEG-coat protein (CP) subunits, likely due steric interference between protein−protein subunits as result presence chains. This thermodynamic...
Abstract The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat antibiotic resistance. Here, we describe novel supramolecular biohybrid nanostructure based on non‐covalent immobilization cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy straightforward protocol, in which binding driven by electrostatic interactions. These biohybrids show strong photodynamic activity...
Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be suitable as photosensitizer this application, it currently used in clinic cancer PDT. In present study, mTHPC was encapsulated polymeric micelles based on benzyl-poly(ε-caprolactone)-b-methoxy poly(ethylene glycol) (Ben-PCL-mPEG) using film hydration method, with loading capacity...
In this paper we describe a straightforward supramolecular strategy to encapsulate silicon phthalocyanine (SiPc) photosensitizers (PS) in polymeric micelles made of poly(ε-caprolactone)-b-methoxypoly(ethylene glycol) (PCL-PEG) block copolymers. While PCL-PEG are promising nanocarriers based on their biocompatibility and biodegradability, the design our new PS favors encapsulation. particular, they combine two axial benzoyl substituents, each them carrying either three hydrophilic...
Photodynamic therapy is a treatment modality of cancer based on the production cytotoxic species upon light activation photosensitizers. Zinc phthalocyanine photosensitizers bearing four or eight bulky 2,6-di(pyridin-3-yl)phenoxy substituents were synthesized, and pyridyl moieties methylated. The quaternized derivatives did not aggregate at all in water retained their good photophysical properties. High photodynamic activity these phthalocyanines was demonstrated HeLa, MCF-7, EA.hy926 cells...
Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are integral cell surface proteins crucial for the regulation of immune responses and maintenance tolerance through interactions with sialic acids.
[Structure: see text] A novel covalently linked bis([60]fullerene)-phthalocyanine triad is reported, exhibiting long-lived photoinduced charge separation both in solution and the solid state. The first demonstration of a working solar cell using 1 as active material also presented.