A5001764059- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Catalytic C–H Functionalization Methods
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Fluorine in Organic Chemistry
- Acupuncture Treatment Research Studies
- Functional Brain Connectivity Studies
- Radical Photochemical Reactions
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Gene expression and cancer classification
- Microtubule and mitosis dynamics
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Allergic Rhinitis and Sensitization
- Peptidase Inhibition and Analysis
University of Science and Technology of China
2018-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2025
Sun Yat-sen University
2024-2025
First Affiliated Hospital of Bengbu Medical College
2022-2025
Zhongshan Hospital
2024
Fudan University
2020-2024
Bengbu Medical College
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Southern University of Science and Technology
2024
To test the utility of "A/T/N" system in Chinese population, we study core Alzheimer's disease (AD) biomarkers a newly established cohort.
Abstract Background CSF-soluble platelet-derived growth factor receptor beta (sPDGFRβ) is closely associated with pericyte damage. However, the changes in CSF sPDGFRβ levels and their role blood – brain barrier (BBB) leakage at different stages of Alzheimer’s disease (AD), or without cerebral small vessel (CSVD) burden, remain unclear. Methods A total 158 individuals from China Aging Neurodegenerative Disorder Initiative cohort were selected, including 27, 48, 83 a clinical dementia rating...
Abstract Cascade radical cyclization constitutes an atom‐ and step‐economic route for rapid assembly of polycyclic molecular skeletons. Although array redox‐active metal catalysts has recently shown robust applications in enabling various catalytic cascade processes, the use free organic as catalyst, which is capable triggering strategically distinct cascades, rarely been developed. Here, we disclosed that benzimidazolium‐based N ‐heterocyclic carbene (NHC)‐boryl catalyzing reactions both...
Pd-catalyzed selective activation of a CF<sub>3</sub> group by consecutive β-F elimination and C–F oxidative addition is reported herein.
Radioisotope-labeled prostate-specific membrane antigen (PSMA) PET tracers have gained popularity in diagnosing prostate cancer (PCa). This study aimed to improve the affinity and tumor-targeting capabilities of new PSMA by increasing number pharmacophores that specifically bind PSMA. Using biphenyl as a core scaffold, we investigated relationship among spacer segments, affinity, pharmacokinetic properties. In preclinical studies on mice with 22Rv1 tumors, compared [68Ga]Ga-PSMA-11 (SUVmax =...
Increasing evidence suggests that organohalogen contaminants (OHCs) could disrupt lipid metabolism in organisms, prompting consideration of fatty acids (FAs) as biological tools for assessing chemical stress systems. This study examined 87 OHCs and 32 FAs two sentinel cetacean species─Indo-Pacific humpback dolphins (n = 128) Indo-Pacific finless porpoises 26)─from the northern South China Sea (NSCS), a global hotspot OHCs. Our results revealed higher OHC levels these cetaceans than averages....
Prostate-specific membrane antigen (PSMA) is a crucial target for prostate cancer (PCa) imaging and therapy. This study developed novel [18F]AlF-labeled dimeric PSMA tracer, [18F]AlF-PSMA-N5, using biphenyl scaffold to improve efficacy. Seven biphenyl-based ligands were synthesized evaluated binding affinity in vivo performance 22Rv1 tumor-bearing mice. [18F]AlF-PSMA-N5 exhibited high (Ki = 0.31 ± 0.06 nM), acceptable radiochemical yield (25.6% 6.6%), purity (>95%). In xenograft models, it...
A decarboxylation of alkyl carboxylic acids for alkylfluorination alkene was developed, with the catalysis silver(I) and Selectfluor as both oxidant fluorine source. This reaction is highly chemoselective, producing decarboxylative products rather than competitive fluorination aliphatic acids. practical transformation proceeds efficiently in aqueous media at room temperature exhibits a large range functional-group tolerance various primary secondary carboxylates alkenes.
Objective.This paper describes the development and validation of a GPU-accelerated Monte Carlo (MC) dose computing module dedicated to organ calculations individual patients undergoing nuclear medicine (NM) internal radiation exposures involving PET/CT examination.Approach. This new extends more-than-10-years-long ARCHER project that developed MC engine by adding NM source-definition features. To validate code, we compared distributions from point ion source, including18F,11C,15O, and68Ga,...
The current diagnoses of Alzheimer's disease (AD) mainly rely on such measures as amyloid-β (Aβ) and tau neuropathology biomarkers in vivo via cerebrospinal fluid (CSF) positron emission tomography (PET) imaging, which had been systematically studied Caucasian individuals, whereas diagnostic performances these approaches Chinese dementia population still remain unclear. This study investigated the associations between levels CSF core AD biomarkers, including phosphorylated (p-Tau181), total...
Early-onset Alzheimer's disease (EOAD) exhibits a notable degree of heterogeneity as compared to late-onset (LOAD). The proteins and pathways contributing the pathophysiology EOAD still need be completed elucidated.
Blood-based biomarkers have been considered as a promising method for the diagnosis of Alzheimer's disease (AD). The reliability and accuracy plasma core AD biomarkers, including phosphorylated tau (P-tau181), total (T-tau), Aβ42, Aβ40, also confirmed in diagnosing predicting cerebral β-amyloid (Aβ) deposition Western populations, while fewer research studies ever conducted China's Han population. In this study, we investigated capability Aβ burden among China Aging Neurodegenerative...
Online dose verification in proton therapy is a critical task for quality assurance. We further studied the feasibility of using wavelet-based machine learning framework to accomplishing that goal three dimensions, built upon our previous work 1D. The wavelet decomposition was utilized extract features acoustic signals and bidirectional long-short-term memory (Bi-LSTM) recurrent neural network (RNN) used. 3D distributions mono-energetic beams (multiple beam energies) inside CT phantom, were...
The vitamin D level in the blood is associated with incidence of hypertension. present study investigated whether or not calcitriol, an active form D, reverses age-related hypertension.Young (3-month-old) and aged (12-month-old) C57BL/6 male mice were administered without calcitriol at 150 ng/kg per day by oral gavage for 8 weeks. Blood pressure was measured tail-cuff plethysmography telemetry, superoxide production renal tissue assessed fluorescence imaging, protein expression AP1/AT1R...
Abstract Cascade radical cyclization constitutes an atom‐ and step‐economic route for rapid assembly of polycyclic molecular skeletons. Although array redox‐active metal catalysts has recently shown robust applications in enabling various catalytic cascade processes, the use free organic as catalyst, which is capable triggering strategically distinct cascades, rarely been developed. Here, we disclosed that benzimidazolium‐based N ‐heterocyclic carbene (NHC)‐boryl catalyzing reactions both...
[18F]-4-((E)-(((E)-4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzylidene)-hydrazono)methyl)-N-methylaniline ([18F]92) is a novel positron emission tomography (PET) tracer previously reported to exhibit high binding affinity aggregated β-amyloid (Aβ). This study aims report fully automated radiosynthesis procedure for [18F]92, explore its radioactive distribution in the brains of healthy subjects, and investigate potential application value early diagnosis Alzheimer's disease (AD). The [18F]92...