Background Type 2 diabetes mellitus (T2DM) presents a significant global health challenge, with increasing prevalence rates. The pathogenesis of early-onset T2DM is complex, the Wnt signaling pathway playing crucial role in islet cell development. Purpose This study was designed to explore association sclerostin (SOST) and low-density lipoprotein receptor-related protein-5 (LRP5) gene polymorphisms young population Uttarakhand, which novel given that no studies have focused on this link...

Introduction Children with clefts have been shown to various nutrient deficiencies including protein energy malnutrition but the levels of vitamin D as compared normal population seldom researched. Materials and Methods Serum Vitamin in children (12 years less), belonging Sub-Himalayan Gangetic Plain regions were age matched using non-parametric tests. Bivariate Logistic regression for estimation odds ratio cleft versus control performed risk insufficiency (less than 30 ng/mL). Results group...

Background: From a human health perspective, fluorine acts as double-edged sword its deficiency leads to dental caries, while excess intake is associated with the development of fluorosis (dental and skeletal). Aims Objectives: This study was conducted aim assessing prevalence different water fluoride concentrations (naturally occurring sources). Additionally, sociodemographic, lifestyle anthropometric measurements were analyzed determine their association fluorosis. Methodology: A...

Background: The influence of smoking on nonsyndromic clefts has been a topic research for many years. However, few studies have investigated the effect causing in different gene pools.Methods: A meta-analysis was conducted case-control related to smoking. Keywords such as “clefts,” “cleft lip,” palate,” “orofacial cleft,” and “smoking” were used search MEDLINE, Embase, Cochrane databases.Results: In total, 51 articles reviewed. RevMan software utilized analysis, Mantel-Haenszel method...

Subclinical Vitamin B12 deficiency is a very common entity in the Indian subcontinent with devastating clinical and socio-economic consequences. The objective of this study was to estimate proportion vitamin deficient children evaluate their profile.This prospective analytical conducted tertiary level care institute Northern India.Children pallor, were included study. Detailed history, height, weight percentiles characteristic features recorded complete blood counts, mean corpuscular volume...

Introduction During a large-scale disease outbreak, one needs to respond the situation quickly towards capacity building, by identifying areas that require training and planning workable strategy implementing it. There are limited studies focused on fast-track workforce creation under challenging circumstances demand mandatory social distancing discouragement of gatherings. This study was conducted analyze process implementation during Coronavirus (COVID-19) pandemic, evaluate its...

Background Type 2 diabetes (T2D) is increasing day by and creating a huge financial social burden on the Indian population. Insulin resistance results in hyperglycemia, condition that eventually causes prediabetes diabetes. The etiopathogenesis of T2D still not clearly defined. Wnt signaling pathway involved pancreas development, islet function, insulin production, secretion. Recent studies show sclerostin, inhibitor, associated with sclerostin level altered as function race ethnicity....

Various indices for estimating insulin sensitivity, based on glucose tolerance test and fasting levels, have been devised. However, they are laborious, time-consuming, costly. Recently, a new index, single point sensitivity estimator (SPISE) TG, high-density lipoproteins (HDL), body mass index (BMI) was proposed in the European population found comparable to gold standard test. Decreased is hallmark of metabolic syndrome (MetS). Hence, current study planned determine optimal cutoff SPISE...

More than 70% of lung cancer comprises nonsmall-cell carcinoma and is associated with poor survival outcome owing to late diagnosis. Identification in early stages when no clinical signs or symptoms are evident, can drastically improve the prognosis. To this end, we aimed evaluate changes occurring at tissue level by assessing expression six microRNAs (miRNAs) adenocarcinoma (AC) squamous cell (SCC).Peripheral blood histopathologically proven cases AC SCC was collected processed for...

Focused studies in different geographic regions would delineate the underlying biological differences and molecular alterations non-small cell lung cancer (NSCLC) worldwide. Previous literature have documented limited characterization by studying a minimal number of markers. This study was done to evaluate expression multiple immunomarkers including diagnostic, prognostic, predictive markers NSCLC for its characterization.This an observational conducted on 60 consecutive cases NSCLC....

Background Paclitaxel (PTX)-induced peripheral neuropathy (PIPN) is nonresponsive to the currently available analgesics. Previous studies have shown role of oxidative stress and central sensitization in development neuropathy. Dimethyl fumarate (DMF) acts as a nuclear factor erythroid-2-related 2 (Nrf2) activator with neuroprotective benefits approved for use multiple sclerosis. Materials methods In current research, we evaluated efficacy DMF on paclitaxel-induced rats. Every alternate day...

Early assessment of the severity an acute cerebral lesion secondary to hypoxia-ischemia or other pathologic conditions may provide a very useful basis for preventive therapeutic decisions in pediatric patients. In present review, we discuss diagnostic and prognostic value series biochemical parameters, with special reference diagnosis neonatal HIE. Currently many specific markers brain injury are being investigated assess regional damage after perinatal asphyxia neonates which serum protein...

To compare the effects of metformin alone versus combined therapy with myoinositol (MI) plus D-chiro-inositol (DCI) in women polycystic ovary syndrome (PCOS).

Among cations of biologic importance, Magnesium (Mg) is the forgotten member, often labeled as fifth electrolyte and sometimes even body's 'orphan ion', because an apparent lack a specific endocrine control. important co-factor in many enzymatic reactions involving energy metabolism, protein nucleic acid synthesis. Ionized Mg physiologically active form element. It has been mentioned various epidemiological correlation studies that low status widely prevalent. Data from indicate about 60%...

Neural tube defects (NTDs) are one of the most common congenital anomalies. NTDs preventable if folic acid (FA) is supplemented before and during conception. Knowledge supplementation FA by pregnant women as well it's timely provision health providers crucial in reducing burden community.To study knowledge prescription/provision providers.A cross-sectional was conducted block Doiwala, District Dehradun, Uttarakhand.A total 400 121 government (5 medical officers, 25 auxiliary nurse midwives...

Background Children with cleft lip and/or palate can be undernourished due to feeding difficulties after birth. A vicious cycle ensues where malnutrition and low body weight precludes the child from having corrective surgery, in absence of which fails gain weight. This study aimed identify proportion malnutrition, including deficiency major micronutrients, namely iron, folate vitamin B12, children thus help finding out what nutritional interventions improve scenario for these children....

To monitor wound pH and surface temperature as predictors of healing in diabetic foot ulcers (DFU).Prospective, observational, time-bound study 18 months, enrolling patients aged to 60 years with uninfected DFU. The was assessed at baseline after that, every week for 4 weeks according the leg ulcer measurement tool (LUMT). Concurrently, were measured. data analyzed using descriptive statistics, a P-value < .05 considered statistically significant.Fifty-four DFU included mean age 55 male...

Chronic cervical spondylitis (CCS), a degenerative disorder of the spine, is known for causing disability among old and young people. Single-nucleotide polymorphisms (SNPs) in various cytokine genes have demonstrated an impactful association with several inflammatory disorders. In present study, we investigated SNPs allelic distribution three most prevalent cytokines genes, IL-1β (-511C/T), TNF-α (-308G/A), TGF-β (-509C/T), along serum levels these 252 subjects. were analyzed using...

Spontaneous perforation of extrahepatic biliary system is a rare and potentially fatal cause acute abdomen. Clinical presentation as peritonitis. This condition rarely suspected peritonitis preoperatively correct diagnosis made during surgery. If suspected, can be by various imaging techniques like hepatobiliary scintigraphy, magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde (ERCP). As these are not readily available, especially in low socioeconomic countries, we...