Healthcare workers (HCWs) actively involved in patient care at tertiary hospitals face significant stress and workload, which may adversely impact their sympatho-vagal balance (SVB). Research has extensively investigated SVB using various techniques, such as heart rate variability (HRV). With its multifaceted approach, yoga been suggested to influence autonomic nervous system function and, consequently, SVB. Thus, this study aims investigate the efficacy of a 4-week module on among HCWs....

ABSTRACT Gallbladder cancer (GBC) is a rare but aggressive malignancy, often diagnosed at advanced stages due to its asymptomatic progression and lack of reliable biomarkers. Chronic inflammation plays crucial role in pathogenesis, with inflammatory pathways contributing tumor development. This study evaluates the diagnostic potential microRNA19a microRNA146a, key regulators oncogenic pathways, distinguishing GBC from cholelithiasis healthy controls. An observational analytical was conducted...

Gallbladder cancer exhibits striking variability in the global rates, reaching epidemic levels for some regions and ethnicities. The basis of its resides differences environmental exposure intrinsic genetic predisposition to carcinogenesis. There is little information present regarding molecular alterations gall bladder (GBC). We, therefore, have evaluated marker expression GBC studied their correlation with clinicopathological staging.This prospective observational study was conducted on...

Free ionic calcium is the metabolically active component of total (TCa) in blood. However, most laboratories report TCa levels that are dependent on serum albumin concentration. Hence, several formulae have evolved to calculate free from after adjustment for albumin. can directly be measured using direction selective electrodes rather than spectrophotometric methods used autoanalyzers.This study compares obtained by measurement direct ion electrode (ISE) and one calculated as a function...

Various indices for estimating insulin sensitivity, based on glucose tolerance test and fasting levels, have been devised. However, they are laborious, time-consuming, costly. Recently, a new index, single point sensitivity estimator (SPISE) TG, high-density lipoproteins (HDL), body mass index (BMI) was proposed in the European population found comparable to gold standard test. Decreased is hallmark of metabolic syndrome (MetS). Hence, current study planned determine optimal cutoff SPISE...

Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest microRNA-based gene regulation. The aim study to identify dysregulated miRNAs GBC investigate their potential therapeutic tools effective targeted treatment strategies....

The present study was conducted to understand the aetiological link between tuberculosis (TB) and sarcoidosis. Sera from smear-positive TB subjects (n = 24), smear-negative sarcoidosis patients 24) healthy controls were collected circulating immune complexes isolated. Sandwich ELISA performed for detecting four highly specific mycobacterial regions of difference (RD) proteins (early secretory antigenic target 6 [ESAT6], 10 KDa culture filtrate protein [CFP10], 21 CFP [CFP21] species [MPT...

Nanoparticles having strong optical and electronic properties are the most widely used materials in sensor development.

Background: Management of hypercalcemia is based on the manifestation symptoms and serum calcium levels. It considered an oncological emergency; therefore, management has to be done urgent basis. Aim: In present study, we analyzed clinicopathological profile, treatment, outcome patients with in solid malignancies at our institute. Methods: We retrospectively medical records diagnosed cancer admitted department radiation oncology hypercalcemia. The parameters studied were age, gender,...

INTRODUCTION: Carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9) have been reported in previous studies to assess the prognosis of gall bladder cancer (GBC) individually combination. However, evidence utility preoperative CA 19-9, CEA 125 ( 125) determining resectability GBC is still lacking. In present study we correlated serum levels tumor markers combined determine GBC. MATERIALS AND METHODS: Seventy one diagnosed patients between January 2018 September 2019 were included...

To assess the role of red cell distribution width as a marker to predict tumor burden in gallbladder cancer (GBC).One hundred and twenty-eight patients with newly diagnosed GBC were included study. Peripheral blood samples obtained, (RDW) was assessed. Tumor markers other biochemical parameters also recorded.Quantitative variables summarized using mean standard deviation or median interquartile range based on normality distribution. The association RDW stage analyzed Chi-square test. All...

INTRODUCTION: Gall bladder cancer (GBC) tends to present in advanced stages, therefore, early diagnosis of GBC is necessary. There no ideal single tumor marker available presently for the and prognosis GBC. Platelet distribution width (PDW) an activated platelets has been used a variety tumors assess prognosis. This study was designed evaluate utility PDW identifying patients its association with markers, staging resectability MATERIALS AND METHODS: cross sectional done on 100 age- sex-...

The diabetic status of the local Jhansi patients (120 cases) was established before and after antileprosy treatment. Control studies were performed in normal healthy subjects (50 persons) without family history diabetes mellitus. Random normals showed an incidence only 2%, while leprosy (94 males 26 females) had 14.2%. highest (19.3%) lepromatous lowest (6.4%) tuberculoid patients. Repeated treatment not clinical improvement for but also disappearance chemical latent mellitus lowering blood...

COVID-19 was declared a pandemic in 2020. It has had devastating effect on human life and the global economy. To date, there is no proven therapy for COVID-19, even though rigorous research ongoing to test multiple compounds across all systems of medicine. A need felt systematically explore Indian system medicine assess its efficacy against COVID-19. The objective present study examine Kabasura Kudineer as standalone following: time required achieve symptom relief & resolution, virological...

Females having a large proportion of gallbladder carcinoma (GBC) and higher incidence gallstones pointed toward the role sex hormones in GBC development. In this study, we evaluated expression Estrogen receptor (ER), Progesterone (PR), Her2/neu their correlation with tumor markers clinicopathological parameters GBC.A total 50 patients 42 control group undergoing surgery for other conditions were taken. The patient's biopsy sample's paraffin block was tested ER, PR, by immunohistochemistry.ER...

Abstract PURPOSE: Lithium (Li) is a well-established drug for the treatment of bipolar affective disorders. Li as known to possess narrow therapeutic index. Thus, regular monitoring blood in patients receiving therapy essential. Plain tubes with clot activator are interfere estimation. The current study was planned compare estimation sera from vacutainers activator, and plasma sodium heparinized that glass vials. time-dependant stability on storage at 2°C–8°C 48 h these three set also...