A5027020738- Lymphatic System and Diseases
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- AI in cancer detection
- Sphingolipid Metabolism and Signaling
- Cutaneous Melanoma Detection and Management
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cell Image Analysis Techniques
- Lymphatic Disorders and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Multiple Sclerosis Research Studies
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
Maurice Wilkins Centre
2014-2025
University of Auckland
2014-2025
The lymphatic sinuses in human lymph nodes (LNs) are crucial to LN function yet their structure remains poorly defined. Much of our current knowledge derives from rodent models, however LNs differ substantially sinus structure, most notably due the presence trabeculae and trabecular that lack. Lymphatic bounded traversed by endothelial cells (LECs). A better understanding LECs is likely improve regulation cell trafficking within LNs, now an important therapeutic target, as well disease...
Introduction Tertiary Lymphoid Structures (TLS) in cancer tissue are potential sites for the organisation of immune responses to cancer, and correlate positively with improved clinical outcomes patients including colorectal (CRC). However it has proven challenging standardise assessment TLS due highly variable appearances circumscribed domains within sections. A recent three-dimensional reconstruction CRC showed that often large, multi-lobular structures, suggesting assessing across whole...
Abstract Tertiary Lymphoid Structures (TLSs) are organized aggregates of immune cells that form in non-lymphoid tissues under chronic inflammation, including cancer. In most cases, TLS presence tumors correlates with improved clinical outcomes, underscoring their prognostic and predictive value. However, standardizing assessment remains challenging due to complex cellular composition, multi-lobular structures, highly variable appearances within tissue sections. Current methods rely largely...
Abstract B‐cell migration within lymph nodes (LNs) is crucial to adaptive immune responses. Chemotactic gradients are proposed drive of B cells into follicles, followed by their relocation specific zones the follicle during activation, and ultimately egress. However, molecular drivers these processes generating chemotactic signals that affect in human LNs not well understood. We used immunofluorescence microscopy, flow cytometry functional assays study mechanisms LNs, found subtle but...
Lymph nodes (LNs) form the intersection between vascular and lymphatic systems. Lymphocytes antigen-presenting cells (APCs) traffic these systems, but barriers crossed during this trafficking in human LNs are poorly defined. We identified a population of that lines boundary parenchyma sinuses, consistent with descriptions marginal reticular (MRCs) murine LNs. Human MRCs CD141(high) podoplanin(+), CD90(+), ICAM1(+), VCAM1(+) lack endothelial hematopoietic cell markers, or alpha-smooth muscle...
Abstract Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play crucial role in enabling T-cell responses, and because tumor metastases modulate their structure function, this interaction may suppress immune responses antigens. The SC subpopulations that respond infiltration malignant into LNs have not been defined. Here, we identify distinctive CD90+ SCs present melanoma-infiltrated compare them with counterparts normal LNs....
Macrophages play essential roles in maintaining tissue homeostasis and immune defence. However, their extensive infiltration into tumours has been linked to adverse outcomes multiple human cancers. Within the tumour microenvironment (TME), tumour-associated macrophages (TAMs) promote growth metastasis, making them prime targets for cancer immunotherapy. Recent single-cell analysis suggest that proliferating TAMs accumulate cancers, yet origins differentiation pathways remain uncertain. Here,...
Abstract Tertiary Lymphoid Structures (TLS) in cancer tissue are potential sites for the organisation of immune responses to cancer, and correlate positively with improved clinical outcomes patients including colorectal (CRC). However it has proven challenging standardise assessment TLS due highly variable appearances circumscribed domains within sections. A recent three-dimensional reconstruction CRC showed that often large, multi-lobular structures, suggesting assessing across whole...
<div>Abstract<p>Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play crucial role in enabling T-cell responses, and because tumor metastases modulate their structure function, this interaction may suppress immune responses antigens. The SC subpopulations that respond infiltration malignant into LNs have not been defined. Here, we identify distinctive CD90<sup>+</sup> SCs present melanoma-infiltrated...
<p>Supplementary Figures 1-6 and Tables 1-7</p>
<p>Supplementary Figures 1-6 and Tables 1-7</p>
<div>Abstract<p>Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play crucial role in enabling T-cell responses, and because tumor metastases modulate their structure function, this interaction may suppress immune responses antigens. The SC subpopulations that respond infiltration malignant into LNs have not been defined. Here, we identify distinctive CD90<sup>+</sup> SCs present melanoma-infiltrated...