A5072772415- Nonmelanoma Skin Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Cutaneous Melanoma Detection and Management
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Cancer Genomics and Diagnostics
- Wound Healing and Treatments
- Reconstructive Facial Surgery Techniques
- Orthopedic Surgery and Rehabilitation
- Antimicrobial Resistance in Staphylococcus
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- Cell Image Analysis Techniques
- Vascular Malformations and Hemangiomas
- Surgical Sutures and Adhesives
- Traumatic Ocular and Foreign Body Injuries
- Streptococcal Infections and Treatments
- Full-Duplex Wireless Communications
- Phagocytosis and Immune Regulation
- COVID-19 and healthcare impacts
- Torture, Ethics, and Law
- Melanoma and MAPK Pathways
- Animal testing and alternatives
- Polyomavirus and related diseases
Auckland District Health Board
2016-2024
University of Auckland
2012-2024
Counties Manukau District Health Board
2018-2022
Middlemore Hospital
2011-2021
Auckland City Hospital
2020
Auckland Institute of Studies
2018
Gillies McIndoe Research Institute
2012
University of Otago
2012
Hutt Hospital
2012
Rogers (United States)
2010
Infantile haemangioma (IH) has recently been reported as an aberrant proliferation and differentiation of a primitive mesoderm-derived haemogenic endothelium regulated by the renin-angiotensin system (RAS), leading us to propose angiotensin converting enzyme (ACE) potential therapeutic target.To present initial results our open-labelled observational clinical trial using captopril, ACE inhibitor (ACEi), in treatment problematic proliferating IH.After screening investigations, infants with IH...
Abstract Background/Objectives Merkel cell carcinoma is an aggressive neuroendocrine skin cancer. Australian studies report high incidence and poor survival rates compared internationally. While New Zealand has a comparable UV index racial composition to Australia, outcomes are currently unknown. The role of polyoma virus in oncogenesis active area research. We describe the with correlation demographic clinical factors including regional prevalence. Methods Retrospective study...
Circulating tumour DNA (ctDNA) analysis promises to improve the clinical care of people with cancer, address health inequities and guide translational research. This observational cohort study used ctDNA follow 29 patients advanced-stage cutaneous melanoma through multiple cycles immunotherapy.A melanoma-specific next-generation sequencing (NGS) panel, droplet digital polymerase chain reaction (ddPCR) mass spectrometry were identify mutations in longitudinal blood plasma samples from...
Surgical site infections (SSIs) represent a costly and preventable complication of cutaneous surgery. However, there is paucity randomized clinical trials investigating antibiotic prophylaxis for reducing SSIs in skin cancer surgery, evidence-based guidelines are lacking. Incisional antibiotics have been shown to reduce the rate before Mohs micrographic but this represents small subset
The trauma and sepsis that follow open fractures wounds may lead to the production of various cytokines. Understanding wound healing requires a direct knowledge specific cytokines respective fluid levels are present at site. An animal model was designed mimics fracture clinical repair human, high-energy fracture. Canine right tibiae were fractured with penetrating, captive-bolt device, then repaired in standard fashion using an interlocking intramedullary nail. Before primary closure,...
Purpose: Community acquired methicillin resistant Staphylococcus aureus (CA-MRSA) infections are reported to be increasing worldwide. In the United States when rates exceed 15% empiric treatment is suggested. The aim of our study was determine local and CA-MRSA within region. Methods: Nine hundred forty-two patients were admitted service during a six-year period with culture-positive hand identified from operative cultures at time surgery. Results: Sixty-six (7.0%) had positive identified....
Skin grafting reflects a common dermatological procedure for closing skin defects. Patient education is important managing expectation and optimising graft take. While health information increasingly accessed on the internet, there are no existing studies assessing their quality.The first 25 results from Google, Microsoft Bing Yahoo! search engines using term 'skin graft' were analysed variety of standard instruments. Readability was assessed Flesch-Kincaid Grade score (FKG), Gunning Fog...
Abstract Background The evidence‐based management of melanoma patients with a positive sentinel lymph node biopsy (SLNB) has undergone dramatic shift following publication practice‐changing surgical trials demonstrating no melanoma‐specific survival advantage for completion dissection (CLND) in this scenario. We aimed to survey how surgeons' clinical practice had shifted response new evidence from these trials, and at time when there was starting become available systemic adjuvant treatments...
Macrophages play essential roles in maintaining tissue homeostasis and immune defence. However, their extensive infiltration into tumours has been linked to adverse outcomes multiple human cancers. Within the tumour microenvironment (TME), tumour-associated macrophages (TAMs) promote growth metastasis, making them prime targets for cancer immunotherapy. Recent single-cell analysis suggest that proliferating TAMs accumulate cancers, yet origins differentiation pathways remain uncertain. Here,...
Background: Community Acquired Methicillin Resistant Staphylococcus aureus (CA-MRSA) rates have been increasing worldwide and contribute to a growing "global health security threat" as reported by the WHO. Our group previously an overall rate of 7% in CA-MRSA upper extremity infections between 2004-2009 at Auckland Regional Hand Unit. This fell below Center for Disease Control (CDC) recommendation empiric antimicrobial cover once local exceed 10-15%. We examined prevalence characteristics...
Surgical site infections (SSIs) represent one of the most common and potentially preventable sources morbidity healthcare cost escalation associated with skin cancer surgery. There is a lack data reporting organisms cultured from SSIs in surgery, guidelines for antibiotic prophylaxis based on pathogens rather than actual organisms. In this study, we sought to define microbiology specific surgery test these against empiric treatment guidelines.All consenting patients presenting Auckland...
INTRODUCTION For general practitioners, practice nurses and community pharmacists in New Zealand, a core duty is to educate patients about sun protection. We aimed evaluate compliance of locally available sunscreens with regional clinical guidelines sunscreen labelling standards, assist clinicians advising consumers on selection. METHODS audited all at two Auckland stores for three Zealand retailers. then assessed accepted protection from the Guidelines Group. further Australia/New consumer...
Sir: We report the first known experience with cranioplasty in setting of untreated malignant osteopetrosis. Malignant osteopetrosis is a rare congenital disorder (one 300,000 live births) arising from total osteoclast dysfunction that manifests infancy as exuberant overgrowth immature bone.1 Its only effective treatment bone marrow transplantation, which must be performed childhood before bony leads to medullary obliteration hematopoietic collapse and death.2 In our case, 9-month-old...
Abstract Background Clinical audit is a critical quality improvement exercise, yet efficient tools are lacking. The main objective of this study was to evaluate recently deployed database in facilitating the process clinical audit, and secondary outcomes free flap reconstruction head neck at our centre. Methods A cancer‐specific customized suit needs multidisciplinary team. Data has been entered prospectively into since March 2018. An over 12‐month period performed using analysed as case...