A5016068761- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects and Toxicity Studies
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Adenosine and Purinergic Signaling
- Obstructive Sleep Apnea Research
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Endoplasmic Reticulum Stress and Disease
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Respiratory Support and Mechanisms
- Reproductive Biology and Fertility
- Trace Elements in Health
- Biochemical Acid Research Studies
University of Chittagong
2025
The University of Texas MD Anderson Cancer Center
2019-2025
Columbia University Irving Medical Center
2023
National Institute of Pharmaceutical Education and Research
2011-2022
John D. Dingell VA Medical Center
2017-2022
Nottingham University Hospitals NHS Trust
2020
Wayne State University
2017
National Institute of Pharmaceutical Education and Research
2016
Molina Center for Energy and the Environment
2014
Recent evidence highlighted that there is a link between type-1 diabetes mellitus and histone deacetylases (HDACs) due to their involvement in beta-cell differentiation, proliferation, function. The present study aimed investigate the protective role of valproic acid (VPA) on function, apoptosis juvenile diabetic rat. Diabetes was induced Sprague–Dawley rats by streptozotocin (75 mg/kg, i.p.) VPA administered at doses 150 300 mg/kg/day for 3 weeks oral route. Various biochemical parameters,...
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine (L-Arg)-induced pancreatic fibrosis Wistar rats. Pancreatic was induced by twice intraperitoneal (i.p.) injections 20% L-Arg (250 mg/100 g) at 2-h interval on day 1, 4, 7, 10, whereas (800 mg/kg/day) administrated for...
Epidermal growth factor receptor (EGFR) amplification and TP53 mutation are the two most common genetic alterations in glioblastoma multiforme (GBM). A comprehensive analysis of TCGA GBM database revealed a subgroup with near mutual exclusivity EGFR mutations indicative role regulating wild-type-p53 (wt-p53) function. The relationship between wt-p53 function remains undefined this study describes biological significance interaction GBM.
People have used herbal medicine for healing since the dawn of human civilization. This study investigated antidiabetic efficacy and lipid profile Mangifera indica. We evaluated activity through alloxan-induced diabetic model. The 750 mg/kg dosage in group 6 yielded statistically significant findings (p < 0.05) regarding efficacy.The receiving a dose exhibited outcomes total cholesterol, HDL, triglycerides, with results 197.40±6.28*, 52.21±4.47*, 101.75±3.29*, respectively (p<0.05)....
Glioblastoma (GBM) is a lethal primary brain cancer with 5.6% five-year survival rate. Tumor treating fields (TTFields) are alternating low-intensity electric that have demonstrated GBM patient benefit. We previously reported 0.5–24 h of TTFields exposure resulted in an increased uptake FITC-dextran fluorescent probes (4–20 kDa) human cells. However, this approach, which fluorescence plate-based detector used to evaluate cells attached glass coverslips, cannot distinguish live vs. dead The...
Elatostema sessile is used by traditional medicinal practitioners to treat various diseases. The methanol extract (MES) and its fractions, including petroleum ether (PES), carbon tetrachloride (TES), chloroform (CES), aqueous soluble fractions (AES), were tested for their antioxidant, cytotoxic, analgesic, sedative properties on Swiss albino mice. In addition, we GCMS determine the bioactive compounds present in MES of E. sessile. had lowest IC50 value (24.95 μg/mL) antioxidant activity,...
Interferon (IFN) signaling contributes to stemness, cell proliferation, death, and cytokine in cancer immune cells; however, the role of IFN glioblastoma (GBM) GBM stem-like cells (GSCs) is unclear. Here, we investigated cancer-cell-intrinsic tumorigenesis GBM. We report here that GSCs tumors exhibited differential cell-intrinsic type I II signaling, high IFN/STAT1 was associated with mesenchymal phenotype poor survival outcomes. In addition, chronic inhibition decreased proliferation...
Abstract Background: Cyclophosphamide (CP) is an alkylating anticancer drug used for the treatment of various cancer and noncancer disorders. Toxicity CP well characterized using different test systems. However, its intestinal genotoxicity cytotoxicity are least explored mechanism not fully investigated. Valproic acid (VPA) has been reported as a histone deacetylase (HDAC) inhibitor, which modulates drugs. The present study aimed to investigate influence VPA on CP-induced in colon mice....
Abstract Cyclophosphamide (CP) is a widely used anticancer and immunosuppressant drug. Nevertheless, clinical utilization of CP limited due to considerable adverse effects toxicities. Nicotinamide (NMD) micronutrient the effect NMD against CP‐induced hepatotoxicity yet unexplored. The present study was designed evaluate chemoprotective hepatic injury in Sprague‐Dawley rats. Hepatotoxicity induced by administration (30 mg/kg/day) for 10 consecutive days intraperitoneal injection. treatment...