A5013617176- Immune Cell Function and Interaction
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Nutrition, Health and Food Behavior
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Helicobacter pylori-related gastroenterology studies
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammatory mediators and NSAID effects
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Dermatology and Skin Diseases
- Caveolin-1 and cellular processes
- Urticaria and Related Conditions
- Tea Polyphenols and Effects
- Atherosclerosis and Cardiovascular Diseases
- Protein Tyrosine Phosphatases
Tohoku University
2014-2023
Shinshu University
2019-2023
Kyoto Pharmaceutical University
2018-2023
Sendai University
2019
RIKEN Center for Sustainable Resource Science
2016
Kihara Institute for Biological Research
2016
Yokohama City University
2016
National Institute of Health Sciences
2015
University of Human Arts and Sciences
2010
National Institute of Nutrition
1987-1995
Stress granules (SGs), which are formed in the plant cytoplasm under stress conditions, transient dynamic sites (particles) for mRNA storage. SGs actively involved protecting mRNAs from degradation. Oligouridylate binding protein 1b (UBP1b) is a component of SGs. The formation microscopically visible cytoplasmic foci, referred to as UBP1b SG, was induced by heat treatment UBP1b-overexpressing Arabidopsis plants (UBP1b-ox). A detailed understanding function UBP1b, however, still not clear....
Regulatory T cells (Tregs) in the tumor microenvironment regulate immunity. Programmed cell death protein 1 (PD-1) is known to be expressed on Tregs and plays crucial roles suppressing However, immune checkpoint inhibitor, anti-PD-1 antibody, promote proliferation of Treg population tumor-infiltrating lymphocytes, thereby restricting efficacy cancer immunotherapy. In this study, we focused curcumin analog GO-Y030, an antitumor chemical. GO-Y030 inhibited immune-suppressive ability via...
Fatty acid-binding protein 7 (FABP7), one of the fatty acid (FA) chaperones involved in modulation intracellular FA metabolism, is highly expressed glioblastoma, and its expression associated with decreased patients' prognosis. Previously, we demonstrated that FABP7 requires binding partner to exert function a mutation FA-binding site affects tumour biology. Here, explored role ligand for proliferation examined mechanism interaction We discovered among several treatment, oleic (OA) boosted...
Regulatory T cells (Tregs) play a crucial role in preventing antitumor immune responses cancer tissues. Cancer tissues produce large amounts of transforming growth factor beta (TGF-β), which promotes the generation Foxp3 + Tregs from naïve CD4 local tumor microenvironment. TGF-β activates nuclear kappa B (NF-κB)/p300 and SMAD signaling, increases number acetylated histones at locus induces gene expression. also helps stabilize The curcumin analog agent, GO-Y030, prevented TGF-β-induced by...
In the present study, a randomized, double-blind, placebo-controlled study was performed to evaluate safety of an excessive intake and efficacy long-term polyphenols derived from apples for moderately underweight obese subjects (long-term intake: 94 subjects; 30 subjects). For each trial, were divided into following two groups: group that drank beverages with apple (600 mg) (hereinafter referred as group) without placebo group). given regular amount beverage (340 g) day 12 weeks. three times...
The nuclear IκB family protein IκBNS is expressed in T cells and plays an important role Interferon (IFN)-γ Interleukin (IL)-2 production. IκB-ζ, the most similar homolog of IκBNS, generation helper (Th)17 cooperation with RORγt, a master regulator Th17 cells. Thus, IκB-ζ deficient mice are resistant to Th17-dependent experimental autoimmune encephalomyelitis (EAE). However, develop autoimmune-like Sjögren syndrome aging. Here we found that IκBNS-deficient (Nfkbid−/−) show resistance against...
Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and strongly correlated with tumor growth, development, metastasis. However, it unclear how the expression FABP5 host affects progression. In this study, using a lung metastasis model mice, we found that FABP5-deficient mice were more susceptible to metastasis, which accompanied by infiltration lower frequency activated natural killer (NK) cells lung. Additionally, deficiency leads impaired maturation NK...
Abstract Plasmacytoid dendritic cells (pDCs) promote viral elimination by producing large amounts of Type I interferon. Recent studies have shown that pDCs regulate the pathogenesis diverse inflammatory diseases, such as cancer. Fatty acid‐binding protein 5 (FABP5) is a cellular chaperone long‐chain fatty acids induce biological responses. Although effects FABP‐mediated lipid metabolism are well studied in various immune cells, its role remains unclear. This study, which compares wild‐type...
Abstract The immune system maintains homeostasis by recognizing and responding to cell death caused various stresses. response is considered be elicited ‘danger signals’ released from necrotic cells. However, the identity of danger signals remains elusive. In this study, we focused on expression chemokines macrophages stimulated with mouse bone-marrow-derived macrophages, chemokine monocyte chemoattractant protein (MCP)-3 was induced at both mRNA levels in heat-killed murine induction MCP-3...
Abstract Fatty acid binding protein 7 (FABP7) is an intracellular fatty chaperon that highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported FABP7 regulates the response to extracellular stimuli by controlling expression of caveolin-1, important component lipid raft. Here, explored detailed mechanisms underlying regulation caveolin-1 using primary cultured FABP7-KO astrocytes as a model loss function NIH-3T3 cells gain function. We...
Abstract The transcriptional regulator IκB-ζ is important for the control of apoptosis in keratinocytes. Thus, IκB-ζ-deficient mice develop autoimmune diseases, such as Sjögren’s syndrome. However, T cells also play a pivotal role To study cells, we generated cell-specific, mice. We observed increased numbers peripheral effector/memory CD4+ and IFN-γ-producing 3-week-old found that can be up-regulated by TGF-β1 naϊve it negatively regulates IFN-γ expression. In addition, Treg-specific,...
Abstract Dietary obesity is regarded as a problem worldwide, and it has been revealed the strong linkage between allergic inflammation. Fatty acid-binding protein 5 (FABP5) expressed in lung cells, such alveolar epithelial cells (ECs) macrophages, plays an important role infectious However, we do not know precise mechanisms on how lipid metabolic change affects In this study, showed that Fabp5 −/− mice exhibited severe symptom of We sought to examine FABP5 inflammation demonstrated...
Isocitrate dehydrogenase 1 (IDH1) is a key enzyme in cellular metabolism. IDH1 mutation (IDH1mut) the most important genetic alteration lower grade glioma, whereas glioblastoma (GB), common malignant brain tumor, often has wild‐type (IDH1wt). Although there no effective treatment yet for neither IDH1wt nor IDHmut GB, it to note that survival span of GB patients significantly shorter than those with IDH1mut GB. Thus, understanding biology and developing molecular‐targeted therapies paramount...
Abstract Tumor metastasis is one of the worst prognostic features cancer. Although a major cause cancer-related deaths, an effective treatment has not yet been established. Here, we explore antitumor effects GO-Y030, curcumin analog, via various mechanisms using mouse model. GO-Y030 B16-F10 melanoma cells inhibited TGF-β expression and glycolysis. The invasion assay results showed almost complete inhibition following treatment. Mouse experiments demonstrated that administration lung tumor...
Abstract Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds estimated as epigallocatechin-(epicatechin) 7 gallate electron-spray ionization time-of-flight mass spectrometry. Epigallocatechin-(epicatechin) (compound 1 ) showed significant anti-cancer activity in PC-3 prostate cancer cells. In particular, compound suppressed the gene...
Plasma cells (PCs), which aim to protect host health, produce various subsets of immunoglobulin (Ig) in response extracellular pathogens. Blimp‐1 (encoded by Prdm1 )—a protein that is highly expressed PCs—is important for PC functions, including the generation Igs. Fatty acid‐binding 3 (FABP3) a carrier polyunsaturated fatty acids (PUFAs) and participates multiple cellular functions. Although functions FABP3 neurons cardiac myocytes are well‐noted, their roles immune remain be fully...
Abstract Altered function of mitochondrial respiratory chain in brain cells is related to many neurodegenerative diseases. NADH Dehydrogenase (Ubiquinone) Fe-S protein 4 (Ndufs4) one the subunits complex I and its mutation human associated with Leigh syndrome. However, molecular biological role Ndufs4 neuronal poorly understood. In this study, upon expression confirmation NeuN-positive neurons, GFAP-positive astrocytes WT mouse hippocampus, we found significant decrease respiration Ndufs4-KO...