A5030642127- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Bone health and treatments
- Tumors and Oncological Cases
- Peptidase Inhibition and Analysis
- BRCA gene mutations in cancer
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- Chemokine receptors and signaling
- Medical Imaging and Pathology Studies
- Multiple Myeloma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Male Breast Health Studies
- Colorectal Cancer Screening and Detection
- Endometrial and Cervical Cancer Treatments
- Protein Tyrosine Phosphatases
- Tannin, Tannase and Anticancer Activities
Akita University
2016-2025
Hirosaki University
2020
Abstract Familial adenomatous polyposis (FAP) is an inherited disorder that follows autosomal dominant inheritance pattern and caused by a germline pathogenic variant in the APC gene. FAP also has extracolonic manifestations, including osteomas, brain tumors, congenital hypertrophy of retinal pigmented epithelium. Desmoid tumor rare soft-tissue often associated with FAP. WNT signal transduction molecule abundantly expressed central nervous system. The truncation mutations gene are...
The immune checkpoint system suppresses T-cell activity. Unlike cytotoxic anticancer drugs that directly kill cells, inhibitors (ICIs) are generally safer by stimulating tumor immunity. However, most clinical trials require patients to have a better performance status (PS), leaving limited evidence for those with poorer PS. In practice, may be classified poor PS due tumor-induced pain and motor dysfunction, even if major organs remain functional. Real-world data on non-small cell lung cancer...
Regulatory T cells (Tregs) play a crucial role in preventing antitumor immune responses cancer tissues. Cancer tissues produce large amounts of transforming growth factor beta (TGF-β), which promotes the generation Foxp3 + Tregs from naïve CD4 local tumor microenvironment. TGF-β activates nuclear kappa B (NF-κB)/p300 and SMAD signaling, increases number acetylated histones at locus induces gene expression. also helps stabilize The curcumin analog agent, GO-Y030, prevented TGF-β-induced by...
Abstract Skin toxicity is the most common adverse event of treatment with immune check point inhibitors. Among them, erythema multiforme a rare occurrence frequency 4%, cases developing grade 1/2 disease. We experienced high major pembrolizumab for anal canal cancer extensive skin metastases. Steroid ointment was ineffective, and lesions blisters expanded to > 45% body surface area. The patient at risk symptom aggravation, pulse therapy methylprednisolone increasing dose oral prednisolone...
Intimal sarcoma is an extremely rare mesenchymal tumor arising in the great vessels. To date, intimal has not been reported patients with Lynch syndrome (LS), even though this lacks DNA mismatch repair ability genetically and prone to various malignancies. This patient was diagnosed LS by Revised Amsterdam Criteria II, she suffered from left pulmonary artery. She had a germline missense variant of PMS2 (c.1399G>A, pV467I) which classified as unknown significance. In her sarcoma, expression...
Tumor angiogenesis inhibition is one of the most potent strategies in cancer chemotherapy. From past clinical studies, vascular endothelial growth factor pathway successfully treats malignant tumors. However, inhibitors alone cannot cure Moreover, resistance to small molecule has also been reported. Herein, we show antiangiogenic potential a newly synthesized curcumin analog, GO ‐Y078, that possibly functions through actin stress fiber formation, resulting mobility inhibition; this mechanism...
Summary The aim of the present study was to determine whether trough plasma concentrations (C 0 ) regorafenib and its metabolites, N-oxide metabolite (M-2) desmethyl (M-5), in 21 patients receiving therapy were affected by albumin-bilirubin (ALBI) grade. Regorafenib administered at dosages ranging from 40 160 mg once daily on a 3-week-on, 1-week-off cycle. C values major metabolites measured high-performance liquid chromatography day 8 after treatment initiation. M-2 M-5 significantly lower...
We report the first pedigree of Lynch syndrome bearing a germ-line MSH2 missense mutation c.1808A>T (Asp603Val). Until now, this mutation, in exon 12 MSH2, was identified as variant unknown significance International Society for Gastrointestinal Hereditary Tumours database. In vitro induction mutagenesis experiments indicated that mutant protein (Asp603Val) is easily degraded embryonic stem cells, albeit there no clinical information concerning mutant. Our includes four patients with...
Abstract Cancer of unknown primary (CUP) is a heterogeneous disease concept involving various malignant tumors. Understanding its pathophysiology often difficult, together with treatment. Here, we present case CUP abdominal lymph node enlargement and elevated carbohydrate antigen 125 levels. It initially resembled favorable prognosis type similar to ovarian cancer, but metastases were observed in cervical nodes, indicating somewhat atypical compared the typical cancer-like CUP. We identified...
Germline mutations of TP53 are responsible for Li-Fraumeni syndrome in its 60-80%. We found a novel germline mutation, TP53: c.997del:p.R333Vfs*12 (NM_000546.6, GRCh, 17:7670713..7670713). The proband is 40-year-old female, who was suffered from osteosarcoma her right forearm at age 11. She also lung adenocarcinoma upper lobe and bone metastasis scapula 37. treated with gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) because EGFR mutation (L747-S752 del)....
Abstract Pancreatic cancer is a malignancy with high mortality rate, accounting for 37 000 people annually in Japan. It rarely diagnosed resectable state, and effective medicines its advanced stage are scarce. Some pancreatic hereditary, ~10% have germline mutations of Breast 1/2 (BRCA1/2). BRCA1/2 key molecules involved homologous recombination to repair DNA double-strand break. Platinum-based drugs poly Adenosine diphosphate ribose (ADP) polymerase inhibitors that induce synthetic...
Clinical efficacy and safety of second line salvage aflibercept for advanced colorectal cancer in Akita prefecture
Introduction: New drugs have improved the outcome of metastatic colorectal cancer treatment. In Japan, more than 10 agents with at least seven different mechanisms such as 5-fluorouracil (5-FU), irinotecan (IRI), oxaliplatin, angiogenesis inhibitors, anti-epidermal growth factor receptor antibodies, regrafenib, and TAS-102, been approved. With increase in number alternatives, importance choosing increases. To suppress toxicities is also necessary. quality life patients should be taken into...
Epstein-Barr virus (EBV) can rarely induce smooth muscle tumors (SMTs). A 20-year-old female patient underwent kidney transplantation for renal failure. Since then, she has been treated with immunosuppressants, including a calcineurin inhibitor, tacrolimus, and prednisolone, owing to the immunological rejection. Three years later, developed large liver (diameter >5 cm) multiple small lung that were identified as EBV-SMTs based on results of biopsy/histopathology. No intervention was...
Abstract Background In 2016, the Comprehensive Guidelines for Diagnosis and Treatment of Bone Metastasis was published. Since then, therapeutic outcomes patients have gradually improved. As life expectancy is a major determinant surgical intervention, strategy should be modified if prolongation survival to achieved. Methods For advanced cancer with bone metastasis who visited Department Clinical Oncology at Akita University hospital between 2012 2023, parameters including site number...
e15518 Background: Gastric cancer is the second cause of death in world, killing more than 700,000 people 2012. The risk factors are Helicobacter pyloriinfection, obesity, smoking, consumption red meat or alcohol. However, an effective preventive measure this disease has bot been established. Curcumin, a dietary pigment, that used for three thousand years, anti-tumor potential. bioavailability curcumin very poor, and it not clinics. Researchers trying to overcome short point. To synthesize...
Cancer of unknown primary (CUP) accounts for 5% all malignancies. Patients with CUP may live averagely 8 months after diagnosis, and thus, rapid reasonable diagnosis is necessary. Among patients CUP, anaplastic lymphoma kinase (ALK)-overexpressing CUPs, whose sites were confirmed to be the lungs (Lung-CUP) by using antibodies against cytokeratin 7, thyroid transcription factor-1, Napsin A, along clinical characteristics progressed rapidly very sensitive ALK inhibitor alectinib. The incidence...
Abstract We report the sensitivity of immune checkpoint inhibitors for tumors developing in a patient bearing MSH2 c.1808A > T (Asp603Val) variant belonging to pedigree Lynch syndrome. This was previously thought be unknown significance, but we recently found that this missense mutation likely pathogenic. At time, there were no active members with malignancies could treated chemotherapy. Thereafter, an 81-year-old woman variant, who cousin proband family, had multiple lymph node...